Endothelial progenitor cells in coronary artery disease

2013 ◽  
Vol 394 (10) ◽  
pp. 1241-1252 ◽  
Author(s):  
Michael Donahue ◽  
Cristina Quintavalle ◽  
Giovanni Alfonso Chiariello ◽  
Gerolama Condorelli ◽  
Carlo Briguori
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Factor ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Vascular Health ◽  
Endothelial Progenitor ◽  
Artery Disease

Abstract In the last two decades a great deal of evidence has been collected on the key role of endothelial progenitor cells (EPC) in the mechanisms of vascular healing. The role of EPC as a marker of vascular health and prognosis of cardiovascular disease is already consolidated. This review aims to examine and evaluate recent data regarding EPC, as biomarkers, prognostic factor and potential therapy in cardiovascular disease.

Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

2011 ◽  
Vol 111 (1) ◽  
pp. 321-328 ◽  
Author(s):  
Karsten Lenk ◽  
Madlen Uhlemann ◽  
Gerhard Schuler ◽  
Volker Adams
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Physical Exercise ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Beneficial Effects ◽  
Endothelial Cell Layer ◽  
Artery Disease

In clinical trials as well as in several animal experiments it is evident that physical exercise is a powerful tool to positively influence the development and/or progression of atherosclerosis and coronary artery disease (CAD). The main target of physical exercise seems to be the maintenance of an intact endothelial cell layer. Since the discovery that endothelial progenitor cells (EPCs) are present in the circulation and the knowledge that exercise, either as a single exercise bout or an exercise training program, have the potency to mobilize EPCs from the bone marrow, the contribution of the EPCs for the preservation or repair of the endothelial cell layer is still under debate. Either the EPCs differentiate into mature endothelial cells, or they stimulate via a paracrine mechanism mature endothelial cells to proliferate. It is still unclear, if the exercise-induced mobilization of EPCs is casually related to the improvement of endothelial function. This review will discuss the role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease.

scholarly journals ENDOTHELIAL PROGENITOR CELLS MOBILIZATION AND RECRUITMENT CORRELATE WITH CORONARY ARTERY DISEASE SEVERITY

2013 ◽  
Vol 61 (10) ◽  
pp. E1139
Author(s):  
Niccolò Mancini ◽  
Chrysanthos Grigoratos ◽  
Maria Elena Lucia Picoi ◽  
Federica Massaro ◽  
Tatiana Santoni ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Disease Severity ◽  
Endothelial Progenitor ◽  
Coronary Artery Disease Severity ◽  
Artery Disease
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