Improvement of gastric mucosal detail in the double-contrast upper gastrointestinal examination utilizing low-dose glucagon

1984 ◽  
Vol 84 (5) ◽  
pp. 87-89
Author(s):  
R Stoecker ◽  
D. Foy
Radiology ◽  
1988 ◽  
Vol 168 (3) ◽  
pp. 593-602 ◽  
Author(s):  
M S Levine ◽  
S E Rubesin ◽  
H Herlinger ◽  
I Laufer

1988 ◽  
Vol 29 (1) ◽  
pp. 49-52
Author(s):  
C. Strandberg ◽  
P. Falkenløve ◽  
S. Dorph ◽  
S. H. Jakobsen ◽  
H. S. Thomsen

The inhibitory effect of glucagon-(1–21)-peptide on the motility of the stomach and duodenum during radiologic double contrast studies was examined. In a randomized trial of equimolar doses of glucagon and glucagon-(1–21)-peptide on 70 patients, glucagon-(1–21)-peptide showed to have a significantly weaker effect than glucagon. Glucagon caused significant increases in plasma-glucose and plasma-insulin, while glucagon-(1–21)-peptide had no such effects. In a subsequent randomized study on 75 patients glucagon-(1–21)-peptide in various doses was tested against placebo. The effect was insignificant from that of placebo at practically all dose levels. No side effects were registered. It is concluded, that glucagon-(1–21)-peptide probably has a certain relaxing effect on the smooth muscle of the stomach and duodenum, but that this effect is too small for practical clinical use.


2020 ◽  
Vol 08 (12) ◽  
pp. E1748-E1753
Author(s):  
Satoshi Ono ◽  
Shun Ito ◽  
Kyohei Maejima ◽  
Shosuke Hosaka ◽  
Kiyotaka Umeki ◽  
...  

Abstract Background and study aims Ultrathin endoscopes are commonly used for surveillance esophagogastroduodenoscopy (EGD) to reduce discomfort associated with scope insertion. However, the flexibility of an ultrathin endoscope is a trade-off between reducing discomfort and lengthening examination time. Patients and methods The EG17-J10 (EG17) is a novel ultrathin endoscope characterized by its tapering body stiffness; however, the flexibility of its tip is comparable to that of the traditional ultrathin endoscope EG16-K10 (EG16). We compared EGD examination time between EG17 and EG16. A total of 319 examinees who underwent EGD from November 2019 to January 2020 at the Chiba-Nishi General Hospital were enrolled. Six examinees were excluded due to past history of surgical resection of the upper gastrointestinal tract or too much food residues; 313 examinees (EG17, 209; EG16,104) were retrospectively analyzed. The examination time was divided into three periods: esophageal insertion time (ET), gastroduodenal insertion time (GDT), and surveillance time of the stomach (ST). The total amount of ET, GDT, and ST was defined as total examination time (TT). Results TT of EGD using EG17 was significantly shorter compared to EGD using EG16 (222.7 ± 68.9 vs. 245.7 ± 78.5 seconds) (P = 0.004). Among the three periods of examination time, ET (66.7 ± 24.1 vs. 76.0 ± 24.1 seconds) (P = 0.001) and GDT (47.9 ± 17.4 vs. 55.2 ± 35.2 seconds) (P = 0.007) of EGD using EG17 were significantly shorter compared to EGD using EG16, except for ST (108.1 ± 51.5.1 vs. 114.5 ± 50.1 seconds) (P = 0.148). Conclusion An ultrathin endoscope with tapering body stiffness can shorten EGD examination time, mainly due to the shortening of insertion time.


2000 ◽  
Vol 95 (9) ◽  
pp. 2218-2224 ◽  
Author(s):  
Henrik Toft Sorensen ◽  
Lene Mellemkjaer ◽  
William J. Blot ◽  
Gunnar Lauge Nielsen ◽  
Flemming Hald Steffensen ◽  
...  

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