Infantile cerebral infarction caused by severe diabetic ketoacidosis in new-onset type 1 diabetes mellitus

2019 ◽  
Vol 32 (12) ◽  
pp. 1391-1394
Author(s):  
Junichi Suzuki ◽  
Tatsuo Fuchigami ◽  
Kengo Kawamura ◽  
Masako Aoki ◽  
Tatsuhiko Urakami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cerebral Infarction ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Cerebral Edema ◽  
Rare Complication ◽  
Case Presentation ◽  
New Onset

Abstract Background Diabetic ketoacidosis (DKA) is a common complication of type 1 diabetes mellitus (T1DM). Infants and children with new-onset T1DM may present with DKA, and the risk of cerebral edema is high in infantile DKA. What is new? Neurological deterioration during an episode of DKA is usually attributed to cerebral edema and cerebrovascular accidents. However, cerebral infarction is a very rare complication in infantile DKA. Case presentation We describe a rare case of infantile cerebral infarction caused by severe DKA in a patient with new-onset T1DM. Conclusions Cerebral infarction is an important intracranial complication in infantile DKA. Careful observation and treatment for DKA during the first 24 h of therapy are necessary in infants with new-onset T1DM because the risk of cerebral infarction is highest during this timeframe.

scholarly journals New-Onset Type 1 Diabetes Mellitus with Diabetic Ketoacidosis and Pancreatitis in a Patient with COVID-19

2021 ◽  
pp. e00915
Author(s):  
Mostafa Alfishawy ◽  
Mahmoud Nassar ◽  
Mahmoud Mohamed ◽  
Moataz Fatthy ◽  
Riem El Messiery
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Onset Type ◽  
New Onset

Acute cerebral infarction and extra pontine myelinolysis in children with new onset type 1 diabetes mellitus

2011 ◽  
Vol 12 (5) ◽  
pp. 513-517 ◽  
Author(s):  
Stefanie Petzold ◽  
Thomas Kapellen ◽  
Manuela Siekmeyer ◽  
Wolfgang Hirsch ◽  
Heike Bartelt ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cerebral Infarction ◽  
Type 1 Diabetes Mellitus ◽  
Acute Cerebral Infarction ◽  
Onset Type ◽  
Pontine Myelinolysis ◽  
New Onset

scholarly journals Diabetic Ketoacidosis at Onset of Type 1 Diabetes: Rates and Risk Factors Today to 15 Years Ago

2019 ◽  
Vol 6 ◽  
pp. 2333794X1987039 ◽  
Author(s):  
Shana Rose Mencher ◽  
Graeme Frank ◽  
Joanna Fishbein
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Public Awareness ◽  
Retrospective Chart Review ◽  
Late Presentation ◽  
New Onset

Diabetic ketoacidosis (DKA) is a serious, potentially lethal complication of type 1 diabetes mellitus that may be present at diagnosis. The aim of this study was to determine factors associated with presentation in DKA in new-onset youth and compare the rate of DKA and risk factors to a similar study 15 years prior. This study was a retrospective chart review of newly diagnosed patients with type 1 diabetes mellitus from 2010 to 2013. Of the 276 patients, 29% presented in DKA, compared with 38% 15 years prior ( P < .002). Those with Medicaid, those misdiagnosed at initial encounter, and those not evaluated by a pediatrician initially were more likely to present in DKA ( P = .002, P = .002, P < .001, respectively). The diagnosis of diabetes was not elicited in one third of patients who ultimately presented in DKA. Pediatricians should be reeducated to ask about polyuria and polydipsia in routine encounters. Furthermore, public awareness initiatives are needed to reduce late presentation in DKA.

scholarly journals Cortisol Levels in Children With Diabetic Ketoacidosis Associated With New-Onset Type 1 Diabetes Mellitus

2017 ◽  
Vol 56 (2) ◽  
pp. 117-122
Author(s):  
Kristen M. Williams ◽  
Pamela Fazzio ◽  
Sharon E. Oberfield ◽  
Mary P. Gallagher ◽  
Gaya S. Aranoff
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Serum Cortisol ◽  
Cross Sectional ◽  
Onset Type ◽  
Cortisol Levels ◽  
New Onset

There is little data documenting cortisol levels in children with diabetic ketoacidosis (DKA), despite the fact that untreated adrenal insufficiency (AI) could worsen the outcome of DKA. In this cross-sectional study, we assessed serum cortisol levels in 28 children with DKA and new onset type 1 diabetes mellitus evaluated at our center over a 5-year period. Average duration of diabetes-related symptoms was positively associated with age ( P = .002), and significantly lower hemoglobin A1c levels were observed in the youngest children. The mean cortisol level was 40.9 µg/dL, with a range of 7.8 to 119 µg/dL. Cortisol levels were found to be inversely associated with serum pH ( P = .007). There was no difference in the clinical outcome of the 4 patients who had cortisol levels less than 18 µg/dL. Overall, we did not find clinical or laboratory evidence of diminished cortisol reserve; however, the possibility of AI must be kept in mind when treating children with DKA.

Identifying Risk Factors for the Development of Diabetic Ketoacidosis in New Onset Type 1 Diabetes Mellitus

2003 ◽  
Vol 42 (7) ◽  
pp. 591-597 ◽  
Author(s):  
Johanna T. Mallare ◽  
Candida C. Cordice ◽  
Barbara A. Ryan ◽  
Dennis E. Carey ◽  
Paula M. Kreitzer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Onset Type ◽  
New Onset
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