Microwave-assisted N-Arylation of Indoles via C(sp2)–N(sp2) Bond Formation by Aromatic Nucleophilic Substitution Reactions

2008 ◽  
Vol 63 (3) ◽  
pp. 298-302 ◽  
Author(s):  
Hui Xu ◽  
Ling-Ling Fan
Keyword(s):  
Reaction Time ◽  
Nucleophilic Substitution ◽  
Bond Formation ◽  
Aryl Halides ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Aromatic Nucleophilic Substitution ◽  
Short Reaction Time ◽  
Microwave Assisted

Microwave-assisted nucleophilic aromatic substitution on aryl halides with different indoles is described. Moderate to good yields are obtained in short reaction time (25 - 40 min) when coupling indoles with fluoro- and chloro-substituted aryl halides under catalyst-free conditions.

One-pot Microwave-assisted Tandem Deprotection of Arylmethanesulfonates / SNAr Reaction for K2CO3-mediated C(Aryl)–O Bond Formation

2007 ◽  
Vol 62 (9) ◽  
pp. 1183-1186 ◽  
Author(s):  
Hui Xu ◽  
Hong-Feng Li
Keyword(s):  
Substitution Reaction ◽  
Bond Formation ◽  
Aryl Halides ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
One Pot ◽  
Diaryl Ethers ◽  
Microwave Assisted ◽  
Snar Reaction

One-pot microwave-assisted tandem deprotection of arylmethanesulfonates / nucleophilic aromatic substitution reaction (SNAr) with activated aryl halides to synthesize asymmetrical diaryl ethers is described.

Rapid Cesium Fluoride Catalyzed Synthesis of 5-Aryloxy-1-phenyl-1H-tetrazoles via Nucleophilic Aromatic Substitution

2020 ◽  
Vol 17 ◽  
Author(s):  
Syed Muhammad Saad ◽  
Shahnaz Perveen ◽  
Itrat Fatima ◽  
Khalid Mohammed Khan
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Nucleophilic Aromatic Substitution ◽  
Synthetic Approach ◽  
Aromatic Substitution ◽  
Short Reaction Time ◽  
Cesium Fluoride ◽  
High Yields

Abstract: A nucleophilic aromatic substitution via a new and facile cesium fluoride catalyzed synthetic approach to get 5-aryloxy-1-phenyl-1H-tetrazoles was developed. Dual usage of cesium fluoride as a nucleophilc catalyst as well as an elec-trophilic catalyst afforded the desired products at room temperature in a short reaction time without purification in high yields. This simple but useful reaction may be a rapid and reliable strategy for the synthesis of tetrazolyl ethers

Microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reactions

2008 ◽  
Vol 49 (32) ◽  
pp. 4687-4689 ◽  
Author(s):  
Hui Xu ◽  
Xinhong Yu ◽  
Leying Sun ◽  
Jing Liu ◽  
Wen Fan ◽  
...  
Keyword(s):  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Microwave Assisted

Nucleophilic aromatic substitution reactions of unactivated aryl halides with thiolate ions in hexamethylphosphoramide

1979 ◽  
Vol 44 (15) ◽  
pp. 2642-2646 ◽  
Author(s):  
Pietro Cogolli ◽  
Filippo Maiolo ◽  
Lorenzo Testaferri ◽  
Marco Tingoli ◽  
Marcello Tiecco
Keyword(s):  
Aryl Halides ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Substitution Reactions
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