Rapid Cesium Fluoride Catalyzed Synthesis of 5-Aryloxy-1-phenyl-1H-tetrazoles via Nucleophilic Aromatic Substitution

2020 ◽  
Vol 17 ◽  
Author(s):  
Syed Muhammad Saad ◽  
Shahnaz Perveen ◽  
Itrat Fatima ◽  
Khalid Mohammed Khan
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Nucleophilic Aromatic Substitution ◽  
Synthetic Approach ◽  
Aromatic Substitution ◽  
Short Reaction Time ◽  
Cesium Fluoride ◽  
High Yields

Abstract: A nucleophilic aromatic substitution via a new and facile cesium fluoride catalyzed synthetic approach to get 5-aryloxy-1-phenyl-1H-tetrazoles was developed. Dual usage of cesium fluoride as a nucleophilc catalyst as well as an elec-trophilic catalyst afforded the desired products at room temperature in a short reaction time without purification in high yields. This simple but useful reaction may be a rapid and reliable strategy for the synthesis of tetrazolyl ethers

scholarly journals A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Amulrao Borse ◽  
Mahesh Patil ◽  
Nilesh Patil ◽  
Rohan Shinde
Keyword(s):  
Reaction Time ◽  
Ambient Temperature ◽  
Room Temperature ◽  
Simple Procedure ◽  
Methanesulfonic Acid ◽  
Phosphorus Pentoxide ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields

An expeditious, one-pot method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using a mixture of phosphorus pentoxide-methanesulfonic acid (Eaton’s reagent) at room temperature under solvent-free conditions is described. The salient features of this method include short reaction time, green aspects, high yields, and simple procedure.

scholarly journals Rapid Reduction of Alkenes and Alkynes over Pd Nanoparticles Supported on Sulfonated Porous Carbon

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Arash Shokrolahi ◽  
Abbas Zali ◽  
Kamal Ghani
Keyword(s):  
Reaction Time ◽  
Porous Carbon ◽  
Room Temperature ◽  
Heterogeneous Reaction ◽  
Low Cost ◽  
Pd Nanoparticles ◽  
Rapid Reduction ◽  
Short Reaction Time ◽  
Novel Method ◽  
High Yields

A novel method has been introduced for rapid reduction of alkenes and alkynes, which may be attractive for chemical industries. This method has some advantages such as simplicity and low cost of reactants. Pd supported on sulfonated porous carbon (SPC) was used as a new catalyst for reduction of alkenes and alkynes to the corresponding alkanes using sodium borohydride. The heterogeneous reaction was conducted in open air at room temperature to produce the desired saturated compounds in high yields (over 96%) and in short reaction time (15 minutes).

scholarly journals An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2501 ◽  
Author(s):  
Tarek S. Ibrahim ◽  
Israa A. Seliem ◽  
Siva S. Panda ◽  
Amany M. M. Al-Mahmoudy ◽  
Zakaria K. M. Abdel-Samii ◽  
...  
Keyword(s):  
Amino Acid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Drug Conjugates ◽  
Cost Efficient ◽  
High Yields

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

Molybdenum carbide as an efficient and durable catalyst for aqueous Knoevenagel condensation

2019 ◽  
Vol 43 (42) ◽  
pp. 16437-16440 ◽  
Author(s):  
Mina Tavakolian ◽  
Mohammad Mahdi Najafpour
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Molybdenum Carbide ◽  
Knoevenagel Condensation ◽  
Aqueous Media ◽  
Short Reaction Time ◽  
Efficient Performance ◽  
High Yields

Molybdenum carbide showed an efficient performance for the Knoevenagel condensation in aqueous media at room temperature, affording the corresponding products in high yields within a short reaction time.

Microwave-assisted N-Arylation of Indoles via C(sp2)–N(sp2) Bond Formation by Aromatic Nucleophilic Substitution Reactions

2008 ◽  
Vol 63 (3) ◽  
pp. 298-302 ◽  
Author(s):  
Hui Xu ◽  
Ling-Ling Fan
Keyword(s):  
Reaction Time ◽  
Nucleophilic Substitution ◽  
Bond Formation ◽  
Aryl Halides ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Aromatic Nucleophilic Substitution ◽  
Short Reaction Time ◽  
Microwave Assisted

Microwave-assisted nucleophilic aromatic substitution on aryl halides with different indoles is described. Moderate to good yields are obtained in short reaction time (25 - 40 min) when coupling indoles with fluoro- and chloro-substituted aryl halides under catalyst-free conditions.

scholarly journals Iodination of industrially important aromatic compounds using N-iodosuccinimide by grinding method

2018 ◽  
Vol 7 (6) ◽  
pp. 477-486
Author(s):  
Vivek Sharma ◽  
Priyanka Srivastava ◽  
Santosh Kumar Bhardwaj ◽  
D.D. Agarwal
Keyword(s):  
Gas Chromatography ◽  
Reaction Time ◽  
Solid State ◽  
Aromatic Compounds ◽  
Room Temperature ◽  
High Yield ◽  
Short Reaction Time ◽  
Grinding Method ◽  
High Yields ◽  
Work Up

Abstract Iodination of various industrially and pharmaceutically important substituted aromatics has been achieved using N-iodosuccinimide (NIS) in solid state by grinding at room temperature. This method provides several advantages such as short reaction time (5–8 min), high yields (94–99%), and nonhazardous and simple work-up procedure. High gas chromatography (GC) purity (95–99.9%) suggests that the reaction is highly selective. Substrates which are sensitive to oxidation, viz aniline and phenols are iodinated smoothly in high yield.

Tyrosine-Selective Bioconjugation with Iminoxyl Radicals

2020 ◽  
Author(s):  
Katsuya Maruyama ◽  
Takashi Ishiyama ◽  
Yohei Seki ◽  
Kounosuke Oisaki ◽  
Motomu Kanai
Keyword(s):  
Reaction Time ◽  
Steric Hindrance ◽  
Room Temperature ◽  
Water Soluble ◽  
Light Irradiation ◽  
Sodium Ascorbate ◽  
Iminoxyl Radical ◽  
Short Reaction Time ◽  
Modified Peptides ◽  
The Stability

A novel Tyr-selective protein bioconjugation using the water-soluble persistent iminoxyl radical is described. The conjugation proceeded with high Tyr-selectivity and short reaction time under biocompatible conditions (room temperature in buffered media under air). The stability of the conjugates was tunable depending on the steric hindrance of iminoxyl. The presence of sodium ascorbate and/or light irradiation promoted traceless deconjugation, restoring the native Tyr structure. The method is applied to the synthesis of a protein-dye conjugate and further derivatization to azobenzene-modified peptides.

scholarly journals A Simple and Green Protocol for 2H-Indazolo[2,1-b]phthalazine-triones Using Grinding Method

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Xiao-chuan Jia ◽  
Jing Li ◽  
Yu Ding ◽  
Bin Zhang ◽  
Na Wang ◽  
...  
Keyword(s):  
Reaction Time ◽  
Sulfonic Acid ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Green Protocol ◽  
Simple Operation ◽  
Grinding Method ◽  
Toluene Sulfonic Acid ◽  
High Yields

A robust, facile, and solvent-free route for the three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in the presence of a catalytic amount ofp-toluene sulfonic acid utilizing grinding has been developed. Short reaction time, simple operation, and high yields are the advantages of this protocol.

Hypervalent Iodine(III)-Catalyzed Epoxidation of β-Cyanostyrenes

Synthesis ◽  
2019 ◽  
Vol 51 (23) ◽  
pp. 4473-4486 ◽  
Author(s):  
Saeesh R. Mangaonkar ◽  
Fateh V. Singh
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Hypervalent Iodine ◽  
Short Reaction Time ◽  
Convenient Approach

A convenient approach for the synthesis of β-cyanoepoxides is illustrated by iodine(III)-catalyzed epoxidation of electron-deficient β-cyanostyrenes, wherein the active catalytic iodine(III) species was generated in situ. The epoxidation of β-cyanostyrenes was performed using 10 mol% PhI as precatalyst in the presence of 2.0 equivalents Oxone as an oxidant and 2.4 equivalents of TFA as an additive at room temperature under ultrasonic radiations. The β-cyanoepoxides were isolated in good to excellent yields in a short reaction time.

A Convenient Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Arylamidines via Chloramine-T Mediated Intramolecular Oxidative N–N Bond Formation

Synthesis ◽  
2019 ◽  
Vol 51 (20) ◽  
pp. 3883-3890
Author(s):  
Ashish Bhatt ◽  
Rajesh K. Singh ◽  
Ravi Kant ◽  
Bhupendra K. Sarma
Keyword(s):  
Reaction Time ◽  
Bond Formation ◽  
Available N ◽  
Short Reaction Time ◽  
Metal Free ◽  
Convenient Synthesis ◽  
Chloramine T ◽  
High Yields ◽  
Short Time

A convenient synthesis of 1,5-fused 1,2,4-triazoles from readily available N-arylamidines is reported. The reaction is efficiently promoted by chloramine-T to afford the desired products mostly in high yields and in relatively short time, through direct metal-free oxidative N−N bond formation. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

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