Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

2009 ◽  
Vol 19 (2) ◽  
pp. 237-264 ◽  
Author(s):  
Sandip B Bharate ◽  
Kumar VS Nemmani ◽  
Ram A Vishwakarma
Keyword(s):  
Type 2 Diabetes ◽  
G Protein ◽  
Small Molecule ◽  
G Protein Coupled Receptor ◽  
Small Molecule Modulators ◽  
G Protein Coupled

Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes

2021 ◽  
Vol 35 ◽  
pp. 116071
Author(s):  
Suresh Pola ◽  
Shailesh R. Shah ◽  
Harikishore Pingali ◽  
Pandurang Zaware ◽  
Baban Thube ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes

2018 ◽  
Vol 9 (5) ◽  
pp. 457-461 ◽  
Author(s):  
Santhosh F. Neelamkavil ◽  
Andrew W. Stamford ◽  
Timothy Kowalski ◽  
Dipshikha Biswas ◽  
Craig Boyle ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G protein-coupled receptor 119 agonist DS-8500a effects on pancreatic β-cells in Japanese type 2 diabetes mellitus patients

2018 ◽  
Vol 10 (1) ◽  
pp. 84-93 ◽  
Author(s):  
Hirotaka Watada ◽  
Masanari Shiramoto ◽  
Shin Irie ◽  
Yasuo Terauchi ◽  
Yuichiro Yamada ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
G Protein Coupled

scholarly journals Metabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes

FEBS Journal ◽  
2021 ◽  
Vol 288 (8) ◽  
pp. 2622-2644 ◽  
Author(s):  
Luiz F. Barella ◽  
Shanu Jain ◽  
Takefumi Kimura ◽  
Sai P. Pydi
Keyword(s):  
Type 2 Diabetes ◽  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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