Sphingosine 1-phosphate receptor agonists: a patent review (2010 – 2012)

2013 ◽  
Vol 23 (7) ◽  
pp. 817-841 ◽  
Author(s):  
Edward Roberts ◽  
Miguel Guerrero ◽  
Mariangela Urbano ◽  
Hugh Rosen
Keyword(s):  
Receptor Agonists ◽  
Patent Review ◽  
Sphingosine 1 Phosphate

Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists

2012 ◽  
Vol 22 (8) ◽  
pp. 2794-2797 ◽  
Author(s):  
Qinghua Meng ◽  
Baowei Zhao ◽  
Qiongfeng Xu ◽  
Xuesong Xu ◽  
Guanghui Deng ◽  
...  
Keyword(s):  
Propionic Acid ◽  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Sphingosine 1 Phosphate

Synthesis of para-Alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists

2003 ◽  
Vol 13 (20) ◽  
pp. 3401-3404 ◽  
Author(s):  
Jeremy J. Clemens ◽  
Michael D. Davis ◽  
Kevin R. Lynch ◽  
Timothy L. Macdonald
Keyword(s):  
Alkyl Aryl ◽  
Receptor Agonists ◽  
Sphingosine 1 Phosphate ◽  
S1p Receptor

Synthesis of para-Alkyl Aryl Amide Analogues of Sphingosine-1-phosphate: Discovery of Potent S1P Receptor Agonists.

ChemInform ◽  
2004 ◽  
Vol 35 (3) ◽  
Author(s):  
Jeremy J. Clemens ◽  
Michael D. Davis ◽  
Kevin R. Lynch ◽  
Timothy L. Macdonald
Keyword(s):  
Alkyl Aryl ◽  
Receptor Agonists ◽  
Sphingosine 1 Phosphate ◽  
S1p Receptor

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists

2005 ◽  
Vol 15 (15) ◽  
pp. 3568-3572 ◽  
Author(s):  
Jeremy J. Clemens ◽  
Michael D. Davis ◽  
Kevin R. Lynch ◽  
Timothy L. Macdonald
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Sphingosine 1 Phosphate

Novel oxytocin receptor agonists and antagonists: a patent review (2002 – 2013)

2013 ◽  
Vol 24 (1) ◽  
pp. 29-46 ◽  
Author(s):  
Yang Yang ◽  
Hao Li ◽  
Richard Ward ◽  
Linghuan Gao ◽  
Ji-Fu Wei ◽  
...  
Keyword(s):  
Oxytocin Receptor ◽  
Receptor Agonists ◽  
Patent Review ◽  
Receptor Agonists And Antagonists

scholarly journals Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation

2019 ◽  
Vol 26 (2) ◽  
pp. 216-228 ◽  
Author(s):  
Thangaraj Karuppuchamy ◽  
Christopher J Tyler ◽  
Luke R Lundborg ◽  
Tamara Pérez-Jeldres ◽  
Abigail K Kimball ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Effective Alternative ◽  
Receptor Agonists ◽  
Therapeutic Alternative ◽  
Sphingosine 1 Phosphate ◽  
Inflammatory Bowel ◽  
S1p Receptor ◽  
S1p Lyase

Sphingosine-1-phosphate (S1P) receptor agonists are a promising therapeutic alternative to anti-integrin antibodies in inflammatory bowel disease. Here, we report that modulation of tissue S1P levels via inhibition of the S1P lyase might be an effective alternative, acting by interference with thymocyte maturation.

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