Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation
Keyword(s):
Sphingosine-1-phosphate (S1P) receptor agonists are a promising therapeutic alternative to anti-integrin antibodies in inflammatory bowel disease. Here, we report that modulation of tissue S1P levels via inhibition of the S1P lyase might be an effective alternative, acting by interference with thymocyte maturation.
Keyword(s):
2019 ◽
Vol 81
(9)
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pp. 1249-1258
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Keyword(s):
2017 ◽
Vol 16
(5)
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pp. 495-503
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Keyword(s):
1999 ◽
Vol 116
(5)
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pp. 1246-1249
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Keyword(s):
2017 ◽
Vol 18
(4)
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pp. 741
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