Excitable axonal domains adapt to sensory deprivation in the olfactory system

Effects of sensory deprivation on the developing mouse olfactory system: a light and electron microscopic, morphometric analysis

Journal of Neuroscience ◽

10.1523/jneurosci.04-03-00638.1984 ◽

1984 ◽

Vol 4 (3) ◽

pp. 638-653 ◽

Cited By ~ 121

Author(s):

TE Benson ◽

DK Ryugo ◽

JW Hinds

Keyword(s):

Morphometric Analysis ◽

Olfactory System ◽

Sensory Deprivation ◽

Electron Microscopic ◽

System A

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Excitable axonal domains adapt to sensory deprivation in the olfactory system

10.1101/2021.01.25.428132 ◽

2021 ◽

Author(s):

Nicholas M George ◽

Wendy B Macklin ◽

Diego Restrepo

Keyword(s):

Olfactory System ◽

Action Potentials ◽

Sensory Deprivation ◽

Mitral Cell ◽

Brain Regions ◽

System Level ◽

Cell Physiology ◽

Firing Patterns ◽

Cell Firing ◽

Axonal Morphology

AbstractThe axon initial segment, nodes of Ranvier, and the oligodendrocyte-derived myelin sheath have significant influence on the firing patterns of neurons and the faithful, coordinated transmission of action potentials to downstream brain regions. In the olfactory bulb, olfactory discrimination tasks lead to adaptive changes in cell firing patterns, and the output signals must reliably travel large distances to other brain regions along highly myelinated tracts. Whether myelinated axons adapt to facilitate olfactory sensory processing is unknown. Here, we investigate the morphology and physiology of mitral cell axons in the adult olfactory system, and show that unilateral sensory deprivation causes system-wide adaptations in axons. Mitral cell spiking patterns and action potentials also adapted to sensory deprivation. Strikingly, both axonal morphology and mitral cell physiology were altered on both the deprived and non-deprived sides, indicating system level adaptations to reduced sensory input. Our work demonstrates a previously unstudied mechanism of plasticity in the olfactory system.

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Ultrastructural analysis of unique glycoconjugates in the rat olfactory system

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100124859 ◽

1992 ◽

Vol 50 (1) ◽

pp. 890-891

Author(s):

James E. Crandall ◽

Linda C. Hassinger ◽

Gerald A. Schwarting

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Monoclonal Antibodies ◽

Olfactory System ◽

Olfactory Bulbs ◽

Temporal And Spatial Patterns ◽

Carbohydrate Epitopes ◽

Olfactory Systems ◽

Temporal And Spatial ◽

Cell Surface Glycoconjugates

Cell surface glycoconjugates are considered to play important roles in cell-cell interactions in the developing central nervous system. We have previously described a group of monoclonal antibodies that recognize defined carbohydrate epitopes and reveal unique temporal and spatial patterns of immunoreactivity in the developing main and accessory olfactory systems in rats. Antibody CC2 reacts with complex α-galactosyl and α-fucosyl glycoproteins and glycolipids. Antibody CC1 reacts with terminal N-acetyl galactosamine residues of globoside-like glycolipids. Antibody 1B2 reacts with β-galactosyl glycolipids and glycoproteins. Our light microscopic data suggest that these antigens may be located on the surfaces of axons of the vomeronasal and olfactory nerves as well as on some of their target neurons in the main and accessory olfactory bulbs.

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