scholarly journals Dual Presynaptic Control by ATP of Glutamate Release via Facilitatory P2X1, P2X2/3, and P2X3 and Inhibitory P2Y1, P2Y2, and/or P2Y4 Receptors in the Rat Hippocampus

2005 ◽  
Vol 25 (27) ◽  
pp. 6286-6295 ◽  
Author(s):  
R. J. Rodrigues
Keyword(s):  
Glutamate Release ◽  
Rat Hippocampus ◽  
Presynaptic Control

scholarly journals K+depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study

2012 ◽  
Vol 167 (5) ◽  
pp. 1003-1020 ◽  
Author(s):  
A Heinrich ◽  
RD Andó ◽  
G Túri ◽  
B Rózsa ◽  
B Sperlágh
Keyword(s):  
Glutamate Release ◽  
Rat Hippocampus

scholarly journals Isolation of Hydroxyoctaprenyl-1′,4′-hydroquinone, a new Octaprenylhydroquinone from the Marine Sponge Sarcotragus spinosulus and Evaluation of its Pharmacological Activity on Acetylcholine and Glutamate Release in the Rat Central Nervous System

2014 ◽  
Vol 9 (11) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Angela Bisio ◽  
Ernesto Fedele ◽  
Anna Pittaluga ◽  
Guendalina Olivero ◽  
Massimo Grilli ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pharmacological Activity ◽  
Marine Sponge ◽  
Glutamate Release ◽  
Rat Hippocampus ◽  
Cholinergic Transmission ◽  
New Class ◽  
Mammalian Central Nervous System

Three polyprenyl-1′,4′-hydroquinone derivatives, heptaprenyl-1′,4′-hydroquinone (1), octaprenyl-1′,4′-hydroquinone (2), and hydroxyoctaprenyl-1′,4′-hydroquinone (3) were isolated from the marine sponge Sarcotragus spinosulus collected at Baia di Porto Conte, Alghero (Italy). Our findings indicate that the compounds isolated from S. spinosulus can significantly modulate the release of glutamate and acetylcholine in the rat hippocampus and cortex and might, therefore, represent the prototype of a new class of drugs regulating glutamatergic and cholinergic transmission in the mammalian central nervous system.

Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats

2017 ◽  
Vol 8 (5) ◽  
pp. 1859-1868 ◽  
Author(s):  
Cheng Wei Lu ◽  
Tzu Yu Lin ◽  
Ting Yang Hsie ◽  
Shu Kuei Huang ◽  
Su Jane Wang
Keyword(s):  
Glutamate Release ◽  
Brain Slices ◽  
Rat Hippocampus ◽  
Nerve Terminals ◽  
Preclinical Models ◽  
Neuroprotective Effects ◽  
Hot Peppers

Capsaicin is the major ingredient in hot peppers of the plantCapsicum genuswith neuroprotective effects in several preclinical models; its effect on glutamate release has been investigated in the rat hippocampus using isolated nerve terminals (synaptosomes) and brain slices.

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