scholarly journals Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III

1987 ◽  
Vol 7 (10) ◽  
pp. 3230-3244 ◽  
Author(s):  
ML Mayer ◽  
AB MacDermott ◽  
GL Westbrook ◽  
SJ Smith ◽  
JL Barker
Keyword(s):  
Spinal Cord ◽  
Voltage Clamp ◽  
Calcium Entry ◽  
Arsenazo Iii ◽  
Spinal Cord Neurons ◽  
Mouse Spinal Cord ◽  
Voltage Gated

scholarly journals Calcium-dependent action potentials in mouse spinal cord neurons in cell culture

1981 ◽  
Vol 220 (2) ◽  
pp. 408-415 ◽  
Author(s):  
Eric J. Heyer ◽  
Robert L. Macdonald ◽  
Gregory K. Bergey ◽  
Phillip G. Nelson
Keyword(s):  
Spinal Cord ◽  
Cell Culture ◽  
Action Potentials ◽  
Spinal Cord Neurons ◽  
Mouse Spinal Cord ◽  
Calcium Dependent

Membrane channels activated by taurine in cultured mouse spinal cord neurons

1989 ◽  
Vol 98 (2) ◽  
pp. 229-233 ◽  
Author(s):  
David Alexander Mathers ◽  
Anoop Grewal ◽  
Yihong Wang
Keyword(s):  
Spinal Cord ◽  
Membrane Channels ◽  
Spinal Cord Neurons ◽  
Mouse Spinal Cord

scholarly journals Serotonin modulates multiple calcium current subtypes in commissural interneurons of the neonatal mouse

2012 ◽  
Vol 107 (8) ◽  
pp. 2212-2219 ◽  
Author(s):  
Matthew D. Abbinanti ◽  
Ronald M. Harris-Warrick
Keyword(s):  
Spinal Cord ◽  
Voltage Clamp ◽  
Calcium Current ◽  
Potassium Current ◽  
Cell Voltage ◽  
Pattern Generator ◽  
Calcium Currents ◽  
Intrinsic Properties ◽  
Mouse Spinal Cord ◽  
Serotonergic Modulation

Calcium currents are critical to the intrinsic properties of neurons and the networks that contain them. These currents make attractive targets for neuromodulation. Here, we examine the serotonergic modulation of specific calcium current subtypes in neonatal (P0-5) intersegmental commissural interneurons (CINs), members of the hindlimb locomotor central pattern generator in the mouse spinal cord. Previous work in our lab showed that serotonin (5-HT) excited CINs in part by reducing a calcium current and thus indirectly reducing the calcium-activated potassium current ( Diaz-Rios et al. 2007 ). We have determined which calcium currents are targets of serotonin modulation. Utilizing whole cell voltage clamp and toxins to specific calcium current subtypes, we found that N- and P/Q-type currents comprise over 60% of the overall calcium current. Blockade of each of these subtypes alone with either ω-conotoxin GVIA or ω-agatoxin TK was unable to occlude 5-HT's reduction of the calcium current. However, coapplication of both blockers together fully occluded 5-HT's reduction of the calcium current. Thus, 5-HT decreases both N- and P/Q-type calcium current to excite neonatal CINs.

Electrophysiological effects of FLFQPQRF amide, an endogenous brain morphine modulating peptide, on cultured mouse spinal-cord neurons

Neuropeptides ◽  
1989 ◽  
Vol 14 (4) ◽  
pp. 253-261 ◽  
Author(s):  
A. Guzman ◽  
P. Legendre ◽  
M. Allard ◽  
S. Geoffre ◽  
J.D. Vincent ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Neurons ◽  
Mouse Spinal Cord ◽  
Electrophysiological Effects
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