scholarly journals The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 ◽  
Vol 12 (9) ◽  
pp. 3665-3670 ◽  
Author(s):  
TJ Coderre ◽  
R Melzack
Keyword(s):  
Amino Acids ◽  
Central Sensitization ◽  
Excitatory Amino Acids ◽  
Tissue Injury

The original description of central sensitization

2018 ◽  
Author(s):  
Sheila Black
Keyword(s):  
Amino Acids ◽  
Dorsal Horn ◽  
Central Sensitization ◽  
Excitatory Amino Acids ◽  
Formalin Test ◽  
Tissue Injury ◽  
Original Description ◽  
Nociceptive Responses ◽  
Landmark Study

The landmark study discussed in this chapter is ‘The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury’, published by Coderre and Melzack in 1992. Previous studies in this field implicate a contribution of excitatory amino acids (EAAs), specifically l-glutamate and l-aspartate, to injury-induced sensitization of nociceptive responses in the dorsal horn of the spinal cord. Repetitive stimulation of primary afferent fibres demonstrated that l-glutamate and NMDA can produce ‘wind-up’ of neuronal dorsal horn activity, and this is blocked by application of NMDA antagonists. This study uses the formalin test as a behavioural model to investigate the mechanisms underlying central sensitization and the role of EAAs, NMDA, their receptors, and their antagonists in this process.

Central sensitization following intradermal injection of capsaicin

1997 ◽  
Vol 20 (3) ◽  
pp. 471-471 ◽  
Author(s):  
William D. Willis
Keyword(s):  
Amino Acids ◽  
Substance P ◽  
Central Sensitization ◽  
Mechanical Allodynia ◽  
Excitatory Amino Acids ◽  
Intradermal Injection ◽  
Mechanical Hyperalgesia ◽  
Spinothalamic Tract ◽  
Nociceptive Neurons ◽  
Primary Hyperalgesia

Intradermal capsaicin in humans causes pain, primary hyperalgesia, and secondary mechanical hyperalgesia and allodynia. Parallel changes occur in the responses of primate spinothalamic tract cells and in rat behavior. Neurotransmitters that trigger secondary mechanical hyperalgesia and allodynia include excitatory amino acids and substance P. Secondary mechanical allodynia is actively maintained by central mechanisms. Our group has investigated mechanisms of central sensitization of nociceptive neurons by examining the responses to intradermal injection of capsaicin. These experiments are pertinent to issues raised by coderre & katz (sect. 2).

Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest

1999 ◽  
Vol 67 (2) ◽  
pp. 371-376 ◽  
Author(s):  
Elaine E Tseng ◽  
Malcolm V Brock ◽  
Christopher C Kwon ◽  
Madhu Annanata ◽  
Mary S Lange ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Amino Acids ◽  
Excitatory Amino Acids ◽  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest

Role of Excitatory Amino Acids in the Control of Growth Hormone Secretion

Endocrine ◽  
2005 ◽  
Vol 28 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Enrique Aguilar ◽  
Manuel Tena-Sempere ◽  
Leonor Pinilla
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Excitatory Amino Acids ◽  
Hormone Secretion ◽  
Growth Hormone Secretion
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