scholarly journals Nerve growth factor (NGF) prevents the shift in ocular dominance distribution of visual cortical neurons in monocularly deprived rats

1992 ◽  
Vol 12 (12) ◽  
pp. 4651-4662 ◽  
Author(s):  
L Maffei ◽  
N Berardi ◽  
L Domenici ◽  
V Parisi ◽  
T Pizzorusso
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cortical Neurons ◽  
Ocular Dominance ◽  
Nerve Growth ◽  
Visual Cortical

Nerve growth factor (NGF) uptake and transport following injection in the developing rat visual cortex

1994 ◽  
Vol 11 (6) ◽  
pp. 1093-1102 ◽  
Author(s):  
Luciano Domenici ◽  
Gigliola Fontanesi ◽  
Antonio Cattaneo ◽  
Paola Bagnoli ◽  
Lamberto Maffei
Keyword(s):  
Visual Cortex ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Critical Period ◽  
Cortical Plasticity ◽  
Ocular Dominance ◽  
Occipital Cortex ◽  
Nerve Growth ◽  
Visual Cortical ◽  
Uptake And Transport

AbstractRecent investigations have shown that cortical nerve growth factor (NGF) infusions during the critical period inhibit ocular-dominance plasticity in the binocular portion of the rat visual cortex. The mechanisms underlying the effects of NGF on visual cortical plasticity are still unclear. To investigate whether during normal development intracortical and/or extracortical cells possess uptake/transport mechanisms for the neurotrophin, we injected 125I-NGF into the occipital cortex of rats at different postnatal ages. Within the cortex, only a few labelled cells were observed. These cells were confined to the vicinity of the injection site and their number depended on the animal's age at the time of injection. Labelled cells were absent at postnatal day (PD) 10 but could be detected between PD 14 and PD 18. They then decreased in number over the following period and were not detected in adult animals. Outside the cortex, neurons of the lateral geniculate nucleus (LGN) were not observed to take up and retrogradely transport NGF at any age after birth. In contrast, retrogradely labelled neurons were found in the basal forebrain. Labelled cells were first observed here at PD 14 and then increased in number until reaching the adult pattern. Our results show that intrinsic and extrinsic neurons are labelled following intracortical injections of iodinated NGF. In both neuronal populations, the uptake and transport of NGF is present over a period corresponding to the critical period for visual cortical plasticity. These findings suggest that NGF may play a role, both intra and extracortically, in plasticity phenomena.

scholarly journals Protection by nerve growth factor against glutamate-induced cytoxicity in cultured cortical neurons.

1994 ◽  
Vol 64 ◽  
pp. 235
Author(s):  
Shun Shimohama ◽  
Yutaka Tamura ◽  
Akinori Akaike ◽  
Tetsuys Tsukahara ◽  
Jun Kimura
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cortical Neurons ◽  
Nerve Growth ◽  
Cultured Cortical Neurons

scholarly journals Dehydroepiandrosterone Stimulates Nerve Growth Factor and Brain Derived Neurotrophic Factor in Cortical Neurons

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anahita Rahmani ◽  
Alireza Shoae-Hassani ◽  
Peyman Keyhanvar ◽  
Danial Kheradmand ◽  
Amir Darbandi-Azar
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Brain Derived Neurotrophic Factor ◽  
Nerve Growth

Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons

1993 ◽  
Vol 632 (1-2) ◽  
pp. 296-302 ◽  
Author(s):  
Shun Shimohama ◽  
Nobuo Ogawa ◽  
Yutaka Tamura ◽  
Akinori Akaike ◽  
Tetsuya Tsukahara ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Protective Effect ◽  
Cortical Neurons ◽  
Nerve Growth ◽  
Cultured Cortical Neurons

Sleep deprivation but not a whisker trim increases nerve growth factor within barrel cortical neurons

2001 ◽  
Vol 898 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Judith A. Brandt ◽  
Lynn Churchill ◽  
Zhiwei Guan ◽  
Jidong Fang ◽  
Lichao Chen ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sleep Deprivation ◽  
Cortical Neurons ◽  
Nerve Growth
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