scholarly journals UNC-31 (CAPS) Is Required for Dense-Core Vesicle But Not Synaptic Vesicle Exocytosis in Caenorhabditis elegans

2007 ◽  
Vol 27 (23) ◽  
pp. 6150-6162 ◽  
Author(s):  
S. Speese ◽  
M. Petrie ◽  
K. Schuske ◽  
M. Ailion ◽  
K. Ann ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Synaptic Vesicle ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis

scholarly journals Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Kwun Nok M Man ◽  
Cordelia Imig ◽  
Alexander M Walter ◽  
Paulo S Pinheiro ◽  
David R Stevens ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Synaptic Vesicle ◽  
Chromaffin Cells ◽  
Chromaffin Cell ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Vesicle Docking ◽  
Large Dense Core Vesicle ◽  
Vesicle Exocytosis

It is currently unknown whether the molecular steps of large dense-core vesicle (LDCV) docking and priming are identical to the corresponding reactions in synaptic vesicle (SV) exocytosis. Munc13s are essential for SV docking and priming, and we systematically analyzed their role in LDCV exocytosis using chromaffin cells lacking individual isoforms. We show that particularly Munc13-2 plays a fundamental role in LDCV exocytosis, but in contrast to synapses lacking Munc13s, the corresponding chromaffin cells do not exhibit a vesicle docking defect. We further demonstrate that ubMunc13-2 and Munc13-1 confer Ca2+-dependent LDCV priming with similar affinities, but distinct kinetics. Using a mathematical model, we identify an early LDCV priming step that is strongly dependent upon Munc13s. Our data demonstrate that the molecular steps of SV and LDCV priming are very similar while SV and LDCV docking mechanisms are distinct.

The Caenorhabditis elegans R13A5.9 gene plays a role in synaptic vesicle exocytosis

2015 ◽  
Vol 463 (4) ◽  
pp. 994-998 ◽  
Author(s):  
Tarou Ogurusu ◽  
Kazumi Sakata ◽  
Tokumitsu Wakabayashi ◽  
Yutaro Shimizu ◽  
Ryuzo Shingai
Keyword(s):  
Caenorhabditis Elegans ◽  
Synaptic Vesicle ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis

scholarly journals Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones

2019 ◽  
Vol 123 (2) ◽  
pp. 219-227 ◽  
Author(s):  
Yuko Koyanagi ◽  
Christina L. Torturo ◽  
Daniel C. Cook ◽  
Zhenyu Zhou ◽  
Hugh C. Hemmings
Keyword(s):  
Calcium Channel ◽  
Synaptic Vesicle ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis ◽  
Presynaptic Calcium

scholarly journals SNARE Complex Oligomerization by Synaphin/Complexin Is Essential for Synaptic Vesicle Exocytosis

Cell ◽  
2001 ◽  
Vol 104 (3) ◽  
pp. 421-432 ◽  
Author(s):  
Hiroshi Tokumaru ◽  
Keiko Umayahara ◽  
Lorenzo L Pellegrini ◽  
Toru Ishizuka ◽  
Hideo Saisu ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Snare Complex ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis
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