scholarly journals Spike-Timing-Dependent Plasticity Induces Presynaptic Changes at Immature Hippocampal Mossy Fiber Synapses

2009 ◽  
Vol 29 (26) ◽  
pp. 8299-8301 ◽  
Author(s):  
F. Lanore ◽  
N. Rebola ◽  
M. Carta
Keyword(s):  
Mossy Fiber ◽  
Spike Timing ◽  
Spike Timing Dependent Plasticity ◽  
Dependent Plasticity

Stable Competitive Dynamics Emerge from Multispike Interactions in a Stochastic Model of Spike-Timing-Dependent Plasticity

2006 ◽  
Vol 18 (10) ◽  
pp. 2414-2464 ◽  
Author(s):  
Peter A. Appleby ◽  
Terry Elliott
Keyword(s):  
Synaptic Plasticity ◽  
Stochastic Model ◽  
Higher Order ◽  
Spike Timing ◽  
Competitive Dynamics ◽  
Spike Timing Dependent Plasticity ◽  
Interaction Function ◽  
Dependent Plasticity ◽  
Order Interaction ◽  
Synaptic Dynamics

In earlier work we presented a stochastic model of spike-timing-dependent plasticity (STDP) in which STDP emerges only at the level of temporal or spatial synaptic ensembles. We derived the two-spike interaction function from this model and showed that it exhibits an STDP-like form. Here, we extend this work by examining the general n-spike interaction functions that may be derived from the model. A comparison between the two-spike interaction function and the higher-order interaction functions reveals profound differences. In particular, we show that the two-spike interaction function cannot support stable, competitive synaptic plasticity, such as that seen during neuronal development, without including modifications designed specifically to stabilize its behavior. In contrast, we show that all the higher-order interaction functions exhibit a fixed-point structure consistent with the presence of competitive synaptic dynamics. This difference originates in the unification of our proposed “switch” mechanism for synaptic plasticity, coupling synaptic depression and synaptic potentiation processes together. While three or more spikes are required to probe this coupling, two spikes can never do so. We conclude that this coupling is critical to the presence of competitive dynamics and that multispike interactions are therefore vital to understanding synaptic competition.

Equation-free analysis of spike-timing-dependent plasticity

2015 ◽  
Vol 109 (6) ◽  
pp. 701-714 ◽  
Author(s):  
Carlo R. Laing ◽  
Ioannis G. Kevrekidis
Keyword(s):  
Spike Timing ◽  
Spike Timing Dependent Plasticity ◽  
Dependent Plasticity

scholarly journals What must come down goes up - the effect of noise on weights in spike-timing-dependent plasticity

2015 ◽  
Vol 16 (S1) ◽  
Author(s):  
Michael Klein ◽  
Angelo Cangelosi ◽  
Thomas Wennekers
Keyword(s):  
Spike Timing ◽  
Spike Timing Dependent Plasticity ◽  
Dependent Plasticity
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