Electroencephalographic Evidence for Individual Neural Inertia in Mice That Decreases With Time

Previous studies have demonstrated that the brain has an intrinsic resistance to changes in arousal state. This resistance is most easily measured at the population level in the setting of general anesthesia and has been termed neural inertia. To date, no study has attempted to determine neural inertia in individuals. We hypothesize that individuals with markedly increased or decreased neural inertia might be at increased risk for complications related to state transitions, from awareness under anesthesia, to delayed emergence or confusion/impairment after emergence. Hence, an improved theoretical and practical understanding of neural inertia may have the potential to identify individuals at increased risk for these complications. This study was designed to explicitly measure neural inertia in individuals and empirically test the stochastic model of neural inertia using spectral analysis of the murine EEG. EEG was measured after induction of and emergence from isoflurane administered near the EC50 dose for loss of righting in genetically inbred mice on a timescale that minimizes pharmacokinetic confounds. Neural inertia was assessed by employing classifiers constructed using linear discriminant or supervised machine learning methods to determine if features of EEG spectra reliably demonstrate path dependence at steady-state anesthesia. We also report the existence of neural inertia at the individual level, as well as the population level, and that neural inertia decreases over time, providing direct empirical evidence supporting the predictions of the stochastic model of neural inertia.

Stochastic model predictive control for driver assistance control of intelligent vehicles considering uncertain driving environment

Advanced driver assistance control faces great challenges in cooperating with the nearby vehicles. The assistance controller of an intelligent vehicle has to provide control efforts properly to prevent possible collisions without interfering with the drivers. This paper proposes a novel driver assistance control method for intelligent ground vehicles to cooperate with the nearby vehicles, using the stochastic model predictive control algorithm. The assistance controller is designed to correct the drivers’ steering maneuvers when there is a risk of possible collisions, so that the drivers are not interfered. To enhance the cooperation between the vehicles, the nearby vehicle motion is predicted and included in the assistance controller design. The position uncertainties of the nearby vehicle are considered by the stochastic model predictive control approach via chance constraints. Simulation studies are conducted to validate the proposed control method. The results show that the assistance controller can help the drivers avoid possible collisions with the nearby vehicles and the driving safety can be guaranteed.

LS-VCE Applied to Stochastic Modeling of GNSS Observation Noise and Process Noise

Stochastic models play a crucial role in global navigation satellite systems (GNSS) data processing. Many studies contribute to the stochastic modeling of GNSS observation noise, whereas few studies focus on the stochastic modeling of process noise. This paper proposes a method that is able to jointly estimate the variances of observation noise and process noise. The method is flexible since it is based on the least-squares variance component estimation (LS-VCE), enabling users to estimate the variance components that they are specifically interested in. We apply the proposed method to estimate the variances for the dual-frequency GNSS observation noise and for the process noise of the receiver code bias (RCB). We also investigate the impact of the stochastic model upon parameter estimation, ambiguity resolution, and positioning. The results show that the precision of GNSS observations differs in systems and frequencies. Among the dual-frequency GPS, Galileo, and BDS code observations, the precision of the BDS B3 observations is highest (better than 0.2 m). The precision of the BDS phase observations is better than two millimeters, which is also higher than that of the GPS and Galileo observations. For all three systems, the RCB process noise ranges from 0.5 millimeters to 1 millimeter, with a data sampling rate of 30 s. An improper stochastic model of the observation noise results in an unreliable ambiguity dilution of precision (ADOP) and position dilution of precision (PDOP), thus adversely affecting the assessment of the ambiguity resolution and positioning performance. An inappropriate stochastic model of RCB process noise disturbs the estimation of the receiver clock and the ionosphere delays and is thus harmful for timing and ionosphere retrieval applications.

A Stochastic Model for Kala-azar Transmission Dynamics in Libo Kemkem, Ethiopia

The objective of this paper is to analyse and demonstrate the dynamics of Kala-azar infected group using stochastic model, particularly using simple SIR model with python script over time. The model is used under a closed population with N = 100, transmission rate coefficient β = 0.09, recovery rate γ = 0.03 and initial condition I(0) = 1. In the paper it is discussed how the Kala-azar infected group behaves through simple SIR model. The paper is completed with stochastic SIR model simulation result and shows stochasticity of the dynamics of Kala-azar infected population over time. Fig. 2 below depicts continuous fluctuations which tells us the disease evolves with stochastic nature and shows random process.Subject: Infectious Disease, Global Health, Health Informatics and Statistical and Computational Physics