scholarly journals Gonadotropin-Releasing Hormone (GnRH) Neuron Excitability Is Regulated by Estradiol Feedback and Kisspeptin

2017 ◽  
Vol 38 (5) ◽  
pp. 1249-1263 ◽  
Author(s):  
Caroline Adams ◽  
Wylie Stroberg ◽  
Richard A. DeFazio ◽  
Santiago Schnell ◽  
Suzanne M. Moenter
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Gnrh Neuron ◽  
Releasing Hormone ◽  
Neuron Excitability

scholarly journals Gonadotropin-Releasing Hormone (GnRH) Neuron in the Forebrain of Male Shiba Goat.

1994 ◽  
Vol 40 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Gustavo Oscar ZUCCOLILLI ◽  
Tomohiro HAMADA ◽  
Masumi ICHIKAWA ◽  
Yuji MORI
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Gnrh Neuron ◽  
Releasing Hormone

scholarly journals Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Xinhuai Liu ◽  
Shel-Hwa Yeo ◽  
H James McQuillan ◽  
Michel K Herde ◽  
Sabine Hessler ◽  
...  
Keyword(s):  
Functional Significance ◽  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Receptor Expression ◽  
Gnrh Neuron ◽  
Neurokinin B ◽  
Releasing Hormone ◽  
Pulsatile Hormone Secretion ◽  
Kndy Neurons

The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out to the gonadotropin-releasing hormone (GnRH) neuron dendrons to drive episodic hormone secretion. Using expansion microscopy, we show that KNDy neurons make abundant close, non-synaptic appositions with the GnRH neuron dendron. Electrophysiology and confocal GCaMP6 imaging demonstrated that, despite all three neuropeptides being released from KNDy terminals, only kisspeptin was able to activate the GnRH neuron dendron. Mice with a selective deletion of kisspeptin from KNDy neurons failed to exhibit pulsatile hormone secretion but maintained synchronized episodic KNDy neuron behavior that is thought to depend on recurrent NKB and dynorphin transmission. This indicates that KNDy neurons drive episodic hormone secretion through highly redundant neuropeptide co-transmission orchestrated by differential post-synaptic neuropeptide receptor expression at the GnRH neuron dendron and KNDy neuron.

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