scholarly journals  -Opioid Receptors in the Nucleus Accumbens Shell Region Mediate the Effects of Amphetamine on Inhibitory Control But Not Impulsive Choice

2011 ◽  
Vol 31 (1) ◽  
pp. 262-272 ◽  
Author(s):  
J. Wiskerke ◽  
D. Schetters ◽  
I. E. van Es ◽  
Y. van Mourik ◽  
B. R. O. den Hollander ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Inhibitory Control ◽  
Opioid Receptors ◽  
Impulsive Choice ◽  
Nucleus Accumbens Shell ◽  
Shell Region

scholarly journals   Opioid Receptors in the Nucleus Accumbens Shell Mediate Escalation of Methamphetamine Intake

2015 ◽  
Vol 35 (10) ◽  
pp. 4296-4305 ◽  
Author(s):  
T. W. Whitfield ◽  
J. E. Schlosburg ◽  
S. Wee ◽  
A. Gould ◽  
O. George ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptors ◽  
Nucleus Accumbens Shell

scholarly journals  -Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

2012 ◽  
Vol 32 (20) ◽  
pp. 6771-6784 ◽  
Author(s):  
S. L. Resendez ◽  
M. Kuhnmuench ◽  
T. Krzywosinski ◽  
B. J. Aragona
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptors ◽  
Pair Bond ◽  
Nucleus Accumbens Shell

Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat

2003 ◽  
Vol 285 (5) ◽  
pp. R999-R1004 ◽  
Author(s):  
Amy F. MacDonald ◽  
Charles J. Billington ◽  
Allen S. Levine
Keyword(s):  
Nucleus Accumbens ◽  
Food Intake ◽  
Ventral Tegmental Area ◽  
Opioid Antagonist ◽  
Nucleus Accumbens Shell ◽  
Mesolimbic Dopamine ◽  
Ventral Tegmental ◽  
Mesolimbic Dopamine Pathway ◽  
Shell Region

The nucleus accumbens shell region (sNAcc) and the ventral tegmental area (VTA) are two major nodes in the mesolimbic dopamine pathway, which mediates reward for various survival behaviors, including feeding. Opioids increase and maintain food intake when injected peripherally and centrally. Opioids in the VTA cause increased release of dopamine in the sNAcc, and when injected into either site, cause an increase in food intake. Animals in this study were double cannulated in the VTA and in the sNAcc and injected with various combinations of naltrexone (NTX) (2.5, 5, and 25 μg/side) and Tyr-d-Ala-Gly-(Me)Phe-Gly-ol (DAMGO) (0.1, 0.3, 1, 3, and 5 nmol/side) in both sites. DAMGO was found to dose dependently increase intake to an equal extent when injected into either site. DAMGO-induced increases in food intake when injected into the VTA were blocked to control levels with the highest dose of NTX injected bilaterally into the sNAcc; however, increases in intake when injected into the sNAcc were blocked only partially by the highest dose of NTX injected bilaterally into the VTA. These results indicate opioid-opioid communication between the two sites; however, the communication may be quite indirect, requiring other sites and transmitters to elicit a change in behavior.

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