POSTPONEMENT OF MENSES, SUPPRESSION OF URINARY GONADOTROPHIN, 17-KGS AND 17-KS IN NORMAL WOMEN TREATED WITH A MEGESTROL-ACETATE/MESTRANOL COMBINATION (DELPREGNIN) FROM DAY 20 OF THE CYCLE

1965 ◽  
Vol 49 (3_Suppl) ◽  
pp. S99 ◽  
Author(s):  
E. Østergaard ◽  
J. Arends ◽  
C. Hamburger ◽  
S. G. Johnsen
Keyword(s):  
Megestrol Acetate ◽  
Normal Women

POSTPONEMENT OF MENSES, SUPPRESSION OF URINARY GONADOTROPHINS, 17-KGS AND 17-KS IN NORMAL WOMEN TREATED WITH A MEGESTROL ACETATE/MESTRANOL COMBINATION (DELPREGNIN) FROM DAY 20 OF THE CYCLE

1966 ◽  
Vol 53 (1) ◽  
pp. 13-23 ◽  
Author(s):  
E. Østergaard ◽  
J. Arends ◽  
Chr. Hamburger ◽  
Svend G. Johnsen
Keyword(s):  
Treatment Period ◽  
Megestrol Acetate ◽  
Menstrual Cycles ◽  
Menstruating Women ◽  
The Mean ◽  
Normal Women

ABSTRACT Ten normally menstruating women, ranging in age from 19—32, received 5 mg of megestrol acetate plus 0.1 mg of mestranol from day 20 of the cycle daily for 20 days. Individual 48 h urine collections were obtained from cycle days 7—8, 13—14, 18—19, and from days 9—10 and 19—20 during the treatment. Each 48 h specimen was assayed for »total« gonadotrophins, 17-KGS and fractionated 17-KS. The basal temperature and occurrence of menstruation were noted before, during and after the treatment. In 7 cases unequivocal suppression of gonadotrophins was observed during the medication period, and all these women had their expected menstruation postponed until after termination of the treatment. The next menstrual cycles were ovulatory and regular in relation to the postponed menstruation. In 3 cases no suppression of gonadotrophins was observed and these same cases had no postponement of menstruation. The mean excretion of 17-ketogenic steroids and of 17-ketosteroids (total 17-KS, dehydroepiandrosterone, androsterone and aetiocholanolone fractions) in the whole group was significantly depressed at the end of the treatment period.

Scanning and Transmission Electron Microscopy of the Endometrium in Women with Ovarian Dysgenesis (Turner'S Syndrome)

1976 ◽  
Vol 34 ◽  
pp. 148-149
Author(s):  
A. González-Angulo ◽  
S. Armendares-Sagrera ◽  
I. Ruíz de Chávez ◽  
H. Marquez-Monter ◽  
R. Aznar
Keyword(s):  
Surface Epithelium ◽  
Secretory Cells ◽  
Turner's Syndrome ◽  
Ciliated Cells ◽  
Turner’S Syndrome ◽  
Exogenous Hormone ◽  
Ovarian Dysgenesis ◽  
Transmission Electron ◽  
Normal Women ◽  
Microscopy Examination

It is a well documented fact that endometrial hyperplasia and adenocarcinoma may develop in women with Turner's syndrome who had received unopposed estrogen treatment (1), as well as in normal women under contraceptive medication with the sequential regime (2). The purpose of the present study was to characterize the possible changes in surface and glandular epithelium in these women who were treated with a sequential regime for a period of between three and eight years. The aim was to find organelle modifications which may lead to the understanding of the biology of an endometrium under exogenous hormone stimulation. Light microscopy examination of endometrial biopsies of nine patients disclosed a proliferative pattern; in two of these, there was focal hyperplasia. With the scanning electron microscope the surface epithelium in all biopsies showed secretory cells with microvilli alternating with non secretory ciliated cells. Regardless of the day of the cycle all biopsies disclosed a large number of secretory cells rich in microvilli (fig.l) with long and slender projections some of which were branching (fig. 2).

Platelet Adhesiveness in Symptomatic Women Taking Oral Contraceptives

1971 ◽  
Vol 26 (03) ◽  
pp. 426-430 ◽  
Author(s):  
T. F Zuck ◽  
J. J Bergin ◽  
Jane M. Raymond ◽  
W. R Dwyre ◽  
D. G Corby
Keyword(s):  
Oral Contraceptives ◽  
Platelet Adhesiveness ◽  
Combined Oral Contraceptives ◽  
Increased Risk ◽  
Normal Women ◽  
Asymptomatic Women

SummaryPlatelet adhesiveness to glass was determined in several groups of women. Increases were found in women developing thrombovascular symptoms while taking combined oral contraceptives, compared to both normal women and asymptomatic users of oral contraceptives. Despite this increase, overlap of the groups did not permit discrimination between symptomatic and asymptomatic women. However, it is possible, that in concert with other coagulation changes, platelet adhesiveness to glass may prove adjunctive in defining women at increased risk of developing thrombovascular symptoms while taking oral contraceptives, and further define the mechanism of the increased risk.

Decreased Levels of Histidine-Rich Glycoprotein (HRG) and Increased Levels of Free Plasminogen in Women on Oral Contraceptives Low in Estrogen

1982 ◽  
Vol 48 (03) ◽  
pp. 283-285 ◽  
Author(s):  
Jørgen Jespersen ◽  
Cornelis Kluft
Keyword(s):  
Oral Contraceptives ◽  
Ethinyl Estradiol ◽  
Relative Increase ◽  
Normal Group ◽  
Plasma Samples ◽  
Normal Women ◽  
Made In

SummaryDeterminations by immunologic methods of histidine-rich glycoprotein (HRG) and plasminogen, were made in plasma samples collected during one normal or hormone induced cycle in 15 young, normal women and in 11 women using oral contraceptives with 30 μg ethinyl estradiol and 150 μg levo-norgestrel. The hormone group showed an increase in plasminogen level to about 150% of normal, while the concentration of HRG was decreased to about 75% of normal. This resulted in a considerable relative increase in the concentration of free plasminogen in the hormone group (calculated from the equilibrium: HRG·plasminogen ⇌ HRG + plasminogen, using KD = 1.0 μM), representing a doubling of that in the normal group. Hence, more plasminogen is available for binding to fibrin and activation in the hormone group.

OESTROGENIC, ANDROGENIC AND GONADOTROPHIC SUBSTANCES IN THE URINE OF NORMAL WOMEN

1948 ◽  
Vol 1 (1) ◽  
pp. 38-60 ◽  
Author(s):  
K. PEDERSEN-BJERGAARD ◽  
M. TØNNESEN
Keyword(s):  
Normal Women

Pituitary responses to a dopamine antagonist at different times of the day in normal women

1982 ◽  
Vol 100 (4) ◽  
pp. 481-485 ◽  
Author(s):  
F. R. Pérez-López ◽  
C. M. González-Moreno ◽  
M. D. Abós ◽  
J. A. Andonegui ◽  
R. H. Corvo
Keyword(s):  
Serum Prolactin ◽  
Dopamine Antagonist ◽  
Hormonal Changes ◽  
Healthy Women ◽  
Serum Lh ◽  
Normal Women ◽  
The Times ◽  
Serum Tsh

Abstract. In order to determine whether or not pituitary responsiveness to the dopaminergic antagonist clebopride changes during the nyctohemeral cycle, 10 healthy women with regular cycles were given 1 mg of clebopride orally at 09.00 h and 24.00 h with at least a 5 day interval between each test. In addition, 5 of the women were given a placebo instead of clebopride at midnight to evaluate the spontaneous hormonal changes. During the 24.00 h test the women had significantly higher P < 0.05) mean TSH basal levels. Serum prolactin (Prl) increased significantly (P < 0.001) after clebopride administration while these changes did not occur when placebo was used instead of clebopride at midnight. The Prl response to clebopride was qualitatively similar at 09.00 h and at 24.00 h. Clebopride given at midnight induced a significant increase (P < 0.05) in serum TSH while this change did not occur when the drug was given at 09.00 h or when placebo was given at midnight. The administration of clebopride resulted in no discernible alterations in serum LH, FSH or GH in either the 09.00 h or the 24.00 h tests. Thus, Prl responses to clebopride were similar in the morning and at midnight, TSH significantly increased after clebopride at midnight whereas this did not occur when the drug was given in the morning, and no significant changes were induced in LH, FSH or GH at the times studied.

Effects of a single oral dose of phenobarbital on prolactin, growth hormone and luteinizing hormone in normal women

1983 ◽  
Vol 103 (3) ◽  
pp. 309-314 ◽  
Author(s):  
G. Rosadini ◽  
P. Masturzo ◽  
G. Rodriguez ◽  
G. Murialdo ◽  
V. Montano ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Power Analysis ◽  
Sleep Pattern ◽  
Absolute Power ◽  
Normal Women

Abstract. The effects of a single oral dose of phenobarbital (PB) on the 24 h secretion of prolactin, growth hormone and luteinizing hormone have been evaluated in normal women. An EEG record was taken and barbiturate levels assayed in serum. A statistically significant decrease of growth hormone 24 h mean levels was observed and growth hormone and prolactin values during sleep were diminished. No changes in luteinizing hormone concentrations were observed. After PB the EEG showed no important alterations in sleep pattern, but on the power analysis an increase above 16 Hz absolute power was detected during the waking period.

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