PERIOVULATORY LEVELS OF PLASMA PROGESTERONE AND LUTEINIZING HORMONE IN WOMEN

1969 ◽  
Vol 62 (1) ◽  
pp. 82-88 ◽  
Author(s):  
Elof D. B. Johansson ◽  
Leif Wide

ABSTRACT Plasma LH and progesterone levels were measured around the time of ovulation in 16 normal menstrual cycles. No increased levels of progesterone were found before the LH peak. The maximal LH peak levels lasted for 16–20 h at which time the plasma progesterone rose to a concentration of 1 to 2 ng/ml. Following the fall in the LH concentration, there was a rapid rise in the plasma progesterone concentration, indicating the formation of a corpus luteum. The lowest basal body temperature coincided with the first significant rise in LH levels.

1978 ◽  
Vol 88 (1) ◽  
pp. 164-168 ◽  
Author(s):  
M. Seppälä ◽  
P. Lehtovirta ◽  
E.-M. Rutanen

ABSTRACT Three of 24 infertile women with a short luteal phase transiently showed chorionic gonadotrophin (HCG) like immunoreactivity in serum as measured by the HCG-beta subunit radioimmunoassay. The plasma progesterone concentration was elevated above the lower normal post-ovulatory level in 2 of these women who also had elevated basal body temperature at the time HCG was detected. Positive HCG reaction coincided with the pre-ovulatory surge of luteinizing hormone (LH) in one patient, but in 2 other cases the LH concentration was low suggesting absence of LH interference. Our results suggest that some infertile women may conceive during their cycles with a short luteal phase and maintain pregnancy until HCG becomes detectable.


1971 ◽  
Vol 66 (4) ◽  
pp. 702-710 ◽  
Author(s):  
U. Larsson-Cohn ◽  
E. D. B. Johansson ◽  
C. Gemzell

ABSTRACT Daily determinations of the plasma level of progesterone and the urinary excretion of oestrogens were performed in five subjects during one control cycle followed by three months of treatment with 0.03 mg of d-norgestrel. The control cycles were ovulatory according to the parameters investigated, although one of the women showed a monophasic basal body temperature. During treatment there was a tendency to a decrease of the oestrogen excretion. Three of the women showed one or several cycles with low progesterone levels. It is believed that this was due to a defective function of the corpus luteum. It seems that the effect of the present drug on the corpus luteum activity was about equal to that of chlormadinone acetate 0.5 mg daily, while 0.3 and 0.5 mg of norethindrone depressed the function more markedly.


2021 ◽  
Vol 17 ◽  
pp. 174550652110499
Author(s):  
Lauren Worsfold ◽  
Lorrae Marriott ◽  
Sarah Johnson ◽  
Joyce C Harper

Background: Period tracking applications (apps) allow women to track their menstrual cycles and receive a prediction for their period dates. The majority of apps also provide predictions of ovulation day and the fertile window. Research indicates apps are basing predictions on assuming women undergo a textbook 28-day cycle with ovulation occurring on day 14 and a fertile window between days 10 and 16. Objective: To determine how the information period tracker apps give women on their period dates, ovulation day and fertile window compares to expected results from big data. Methods: Five women’s profiles for 6 menstrual cycles were created and entered into 10 apps. Cycle length and ovulation day for the sixth cycle were Woman 1—Constant 28 day cycle length, ovulation day 16; Woman 2—Average 23 day cycle length, ovulation day 13; Woman 3—Average 28 day cycle length, ovulation day 17; Woman 4—Average 33 day cycle length, ovulation day 20; and Woman 5—Irregular, average 31 day cycle length, ovulation day 14. Results: The 10 period tracker apps examined gave conflicting information on period dates, ovulation day and the fertile window. For cycle length, the apps all predicted woman 1’s cycles correctly but for women 2–5, the apps predicted 0 to 8 days shorter or longer than expected. For day of ovulation, for women 1–4, of the 36 predictions, 3 (8%) were exactly correct, 9 predicted 1 day too early (25%) and 67% of predictions were 2–9 days early. For woman 5, most of the apps predicted a later day of ovulation. Conclusion: Period tracker apps should ensure they only give women accurate information, especially for the day of ovulation and the fertile window which can only be predicted if using a marker of ovulation, such as basal body temperature, ovulation sticks or cervical mucus.


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