EFFECTS OF CONTINUOUS DAILY ADMINISTRATION OF 0.03 mg OF d-NORGESTREL ON THE PLASMA LEVELS OF PROGESTERONE AND THE URINARY EXCRETION OF OESTROGENS

ABSTRACT Daily determinations of the plasma level of progesterone and the urinary excretion of oestrogens were performed in five subjects during one control cycle followed by three months of treatment with 0.03 mg of d-norgestrel. The control cycles were ovulatory according to the parameters investigated, although one of the women showed a monophasic basal body temperature. During treatment there was a tendency to a decrease of the oestrogen excretion. Three of the women showed one or several cycles with low progesterone levels. It is believed that this was due to a defective function of the corpus luteum. It seems that the effect of the present drug on the corpus luteum activity was about equal to that of chlormadinone acetate 0.5 mg daily, while 0.3 and 0.5 mg of norethindrone depressed the function more markedly.

Download Full-text

EFFECTS OF CONTINUOUS DAILY ADMINISTRATION OF 0.3 mg OF NOREHTINDRONE ON THE PLASMA LEVELS OF PROGESTERONE AND ON THE URINARY EXCRETION OF PREGNANEDIOL AND TOTAL OESTROGENS

Acta Endocrinologica ◽

10.1530/acta.0.0640038 ◽

1970 ◽

Vol 64 (1) ◽

pp. 38-46 ◽

Cited By ~ 16

Author(s):

U. Larsson-Cohn ◽

E. D. B. Johansson ◽

C. Gemzell

Keyword(s):

Plasma Level ◽

Urinary Excretion ◽

Corpus Luteum ◽

Plasma Levels ◽

Continuous Treatment ◽

Daily Administration ◽

Hormone Levels ◽

Chlormadinone Acetate

ABSTRACT Daily determinations of the plasma level of progesterone and the urinary excretion of total oestrogens and pregnanediol were performed in 7 subjects during one control cycle, followed by three months of daily continuous treatment with 0.3 mg of norethindrone (NET). The control cycles were ovulatory according to the parameters investigated. During treatment there was a tendency to cyclically increased oestrogen excretion, this being most marked in cycles with very depressed progesterone-pregnanediol levels. All the subjects showed signs of cyclical luteal activity. In most cases, the levels of progesterone and pregnanediol were lower than during the corresponding control cycles. It is suggested that this might be due to deficient corpus luteum function. The drug had no thermogenic effect. The length of the treatment cycles varied between 22 and 49 days. Only two of the women showed intermenstrual bleeding. It seems that 0.3 mg of NET has a weaker effect on the hormone levels than 0.5 mg of NET, but a stronger effect than 0.5 mg of chlormadinone acetate.

Download Full-text

EFFECTS OF CONTINUOUS DAILY ADMINISTRATION OF 0.5 mg OF CHLORMADINONE ACETATE ON THE PLASMA LEVELS OF PROGESTERONE AND ON THE URINARY EXCRETION OF LUTEINIZING HORMONE AND TOTAL OESTROGENS

Acta Endocrinologica ◽

10.1530/acta.0.0630705 ◽

1970 ◽

Vol 63 (4) ◽

pp. 705-716 ◽

Cited By ~ 12

Author(s):

U. Larsson-Cohn ◽

E. D. B. Johansson ◽

L. Wide ◽

C. Gemzell

Keyword(s):

Luteinizing Hormone ◽

Plasma Level ◽

Urinary Excretion ◽

Corpus Luteum ◽

Plasma Levels ◽

Chlormadinone Acetate ◽

The Mean ◽

Low Levels ◽

The Difference ◽

All Treatment

ABSTRACT Daily determinations of the plasma level of progesterone and the urinary excretion of luteinizing hormone (LH) and total oestrogens were performed in 6 subjects during one control cycle, immediately followed by three cycles of daily treatment with 0.5 mg of chlormadinone acetate continuously. The control cycles were ovulatory according to the parameters investigated. Two of the women showed a normal LH excretion pattern in all treatment cycles. The four other subjects also had periodical variations in the LH excretion but no distinct midcycle peaks occurred. The mean oestrogen excretion was increased in all three treatment cycles but the difference was satistically significant only in the last two cycles. Compared with the treatment cycles, the sum of progesterone values was significantly decreased in the first two cycles. Chlormadinone acetate in this dose had no thermogenic effect. Three of the subjects showed bleeding irregularities which had no clear connection with the hormone variations measured in the study. It is suggested that the low levels of progesterone might be due to a defective corpus luteum function.

Download Full-text

PERIOVULATORY LEVELS OF PLASMA PROGESTERONE AND LUTEINIZING HORMONE IN WOMEN

Acta Endocrinologica ◽

10.1530/acta.0.0620082 ◽

1969 ◽

Vol 62 (1) ◽

pp. 82-88 ◽

Cited By ~ 41

Author(s):

Elof D. B. Johansson ◽

Leif Wide

Keyword(s):

Body Temperature ◽

Luteinizing Hormone ◽

Corpus Luteum ◽

Basal Body ◽

Significant Rise ◽

Rapid Rise ◽

Progesterone Concentration ◽

Basal Body Temperature ◽

Plasma Progesterone ◽

Menstrual Cycles

ABSTRACT Plasma LH and progesterone levels were measured around the time of ovulation in 16 normal menstrual cycles. No increased levels of progesterone were found before the LH peak. The maximal LH peak levels lasted for 16–20 h at which time the plasma progesterone rose to a concentration of 1 to 2 ng/ml. Following the fall in the LH concentration, there was a rapid rise in the plasma progesterone concentration, indicating the formation of a corpus luteum. The lowest basal body temperature coincided with the first significant rise in LH levels.

Download Full-text

PLASMA LEVELS OF LUTEINIZING HORMONE IN WOMEN AND IN RATS AS MEASURED BY BIOASSAY

Journal of Endocrinology ◽

10.1677/joe.0.0540119 ◽

1972 ◽

Vol 54 (1) ◽

pp. 119-123 ◽

Cited By ~ 3

Author(s):

J. WATSON

Keyword(s):

Menstrual Cycle ◽

Body Temperature ◽

Luteinizing Hormone ◽

Basal Body ◽

Plasma Levels ◽

Human Subjects ◽

Oestrous Cycle ◽

Basal Body Temperature ◽

Lh Secretion

SUMMARY Plasma levels of luteinizing hormone (LH) in normally cyclic women during the menstrual cycle and in rats during the oestrous cycle were measured by bioassay. With the human subjects, it was possible to establish a mid-cycle peak of LH and correlate it with basal body temperature, while with the rats a peak of LH secretion was noted between 15.00 and 19.00 h on the day of pro-oestrus. The levels of LH in both groups of subjects were of the same order as those measured by other assay techniques.

Download Full-text

Monitoring of ovarian activity by measurement of urinary excretion rates using the Ovarian Monitor, Part IV: the relationship of the pregnanediol glucuronide threshold to basal body temperature and cervical mucus as markers for the beginning of the post-ovulatory infertile period

Human Reproduction ◽

10.1093/humrep/dev303 ◽

2015 ◽

pp. dev303 ◽

Cited By ~ 4

Author(s):

Leonard F. Blackwell ◽

Pilar Vigil ◽

María Elena Alliende ◽

Simon Brown ◽

Mario Festin ◽

...

Keyword(s):

Body Temperature ◽

Urinary Excretion ◽

Basal Body ◽

Cervical Mucus ◽

Ovarian Activity ◽

Basal Body Temperature ◽

Excretion Rates ◽

Relationship Of ◽

The Relationship

Download Full-text

Correlations of Basal Body Temperature, State of the Endometrium and Corpus Luteum, and Prognosis for Pregnancy in Infertility Patients

Fertility and Sterility ◽

10.1016/s0015-0282(16)35654-0 ◽

1965 ◽

Vol 16 (4) ◽

pp. 549-555 ◽

Cited By ~ 1

Author(s):

Edgardo G. Leonidas ◽

Herbert W. Horne ◽

Hazel M. Gore

Keyword(s):

Body Temperature ◽

Corpus Luteum ◽

Basal Body ◽

Basal Body Temperature ◽

Temperature State ◽

Infertility Patients

Download Full-text

Urinary Hormone Excretion Patterns during Low-Dose Progestogen Administration

Journal of International Medical Research ◽

10.1177/030006057500300202 ◽

1975 ◽

Vol 3 (2) ◽

pp. 63-72

Author(s):

L Varga ◽

E Tamme

Keyword(s):

Body Temperature ◽

Corpus Luteum ◽

Basal Body ◽

Low Dose ◽

Ovarian Function ◽

Basal Body Temperature ◽

Term Administration ◽

Hormone Excretion ◽

Female Subjects

The effects on pituitary-ovarian function of long-term administration of 0·5 mg of lynestrenol and 0·35 mg of norethisterone in continuous daily doses were investigated in 9 female subjects. The parameters employed were the basal body temperature charts and urinary assays of LH, total oestrogen and pregnanediol. At the start of administration, ovulation was usually inhibited, but as a rule this effect disappeared as administration continued. Corpus luteum function appeared to be reduced.

Download Full-text

EFFECTS OF CONTINUOUS DAILY ADMINISTRATION OF 0.5 MG OF NORETHINDRONE ON THE PLASMA LEVELS OF PROGESTERONE AND ON THE URINARY EXCRETION OF LUTEINIZING HORMONE, PREGNANEDIOL AND TOTAL OESTROGENS

Acta Endocrinologica ◽

10.1530/acta.0.0630216 ◽

1970 ◽

Vol 63 (2) ◽

pp. 216-224 ◽

Cited By ~ 21

Author(s):

U. Larsson-Cohn ◽

E. D. B. Johansson ◽

L. Wide ◽

C. Gemzell

Keyword(s):

Luteinizing Hormone ◽

Plasma Level ◽

Urinary Excretion ◽

Plasma Levels ◽

The Other ◽

Daily Treatment ◽

Daily Administration ◽

Menstrual Bleeding ◽

Biphasic Pattern

ABSTRACT Daily determinations of the plasma level of progesterone and the urinary excretion of LH, total oestrogens and pregnanediol were performed in 4 subjects during one control cycle, immediately followed for 2 or 3 months of daily treatment with 0.5 mg of norethindrone continuously. The control cycles were ovulatory according to all the parameters investigated. During treatment the mid-cycle LH peak disappeared in all cases while the basal LH excretion showed considerable day to day variations. The excretion of total oestrogens was increased in all subjects but did not show the normal biphasic pattern. Periods of increased oestrogen excretion also appeared in the subjects with consistently low progesterone and pregnanediol levels during the treatment. In two cases, all signs of luteal activity immediately disappeared after the commencement of treatment. The other cases had one and three periods of increased progesterone and pregnanediol levels respectively. However, these periods were shorter than those of the control cycles. One of the subjects had regular menstrual bleeding while the other three had more or less irregular vaginal flows, often appearing during elevated but declining oestrogen excretion.

Download Full-text