Interaction of calcitonin and calcitonin gene-related-peptide at the calcitonin receptor in T 47 D cells

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S200
Author(s):  
A. ZINK ◽  
H.G. SCHNEIDER ◽  
F. RAUE
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Calcitonin Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
D Cells

A New Calcitonin-Receptor-like Sequence in Rat Pulmonary Blood Vessels

1993 ◽  
Vol 85 (4) ◽  
pp. 385-388 ◽  
Author(s):  
F. Njuki ◽  
C. G. Nicholl ◽  
A. Howard ◽  
J. C. W. Mak ◽  
P. J. Barnes ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Vascular Tone ◽  
Islet Amyloid Polypeptide ◽  
Calcitonin Gene Related Peptide ◽  
Binding Activity ◽  
Calcitonin Receptor ◽  
Islet Amyloid ◽  
Related Peptide ◽  
Calcitonin Gene

1. Two rat clones have been isolated which are similar to known calcitonin-receptor sequences. One of these does not have the distribution expected of a calcitonin receptor. It is widely distributed, with extremely high levels of expression in the lung, where it is associated with the blood vessels. 2. This rat sequence may represent the receptor for calcitonin-gene-related peptide or islet amyloid polypeptide. Both have binding activity in the lung and are potent vasodilators. The gene represented by this sequence may therefore play an important role in the maintenance of vascular tone.

A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts

2007 ◽  
Vol 560 (2-3) ◽  
pp. 234-239 ◽  
Author(s):  
Michitaka Notoya ◽  
Rumiko Arai ◽  
Takeshi Katafuchi ◽  
Naoto Minamino ◽  
Hiromi Hagiwara
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Calcitonin Receptor ◽  
Related Peptide ◽  
Peptide Family ◽  
Calcitonin Gene

scholarly journals Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity

2007 ◽  
Vol 293 (4) ◽  
pp. H2155-H2160 ◽  
Author(s):  
Thomas H. Kunz ◽  
Michelle Scott ◽  
Lars M. Ittner ◽  
Jan A. Fischer ◽  
Walter Born ◽  
...  
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Transgenic Mice ◽  
Sympathetic Neurons ◽  
Calcitonin Gene Related Peptide ◽  
Calcitonin Receptor ◽  
Inotropic Effects ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
And Control

Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are potent vasodilators and exert positive chronotropic and inotropic effects on the heart. Receptors for CGRP and AM are calcitonin receptor-like receptor (CLR)/receptor-activity-modifying protein (RAMP) 1 and CLR/RAMP2 heterodimers, respectively. The present study was designed to delineate distinct cardiovascular effects of CGRP and AM. Thus a V5-tagged rat CLR was expressed in transgenic mice in the vascular musculature, a recognized target of CGRP. Interestingly, basal arterial pressure and heart rate were indistinguishable in transgenic mice and in control littermates. Moreover, intravenous injection of 2 nmol/kg CGRP, unlike 2 nmol/kg AM, decreased arterial pressure equally by 18 ± 5 mmHg in transgenic and control animals. But the concomitant increase in heart rate evoked by CGRP was 3.7 times higher in transgenic mice than in control animals. The effects of CGRP in transgenic and control mice, different from a decrease in arterial pressure in response to 20 nmol/kg AM, were suppressed by 2 μmol/kg of the CGRP antagonist CGRP(8-37). Propranolol, in contrast to hexamethonium, blocked the CGRP-evoked increase in heart rate in both transgenic and control animals. This was consistent with the immunohistochemical localization of the V5-tagged CLR in the superior cervical ganglion of transgenic mice. In conclusion, hypotension evoked by CGRP in transgenic and control mice was comparable and CGRP was more potent than AM. Unexpectedly, the CLR/RAMP CGRP receptor overexpressed in postganglionic sympathetic neurons of transgenic mice enhanced the positive chronotropic action of systemic CGRP.

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