Cushing's syndrome and autonomous thyroid nodules, a variant of multiple endocrine neoplasia?

1986 ◽  
Vol 113 (3) ◽  
pp. 463-464 ◽  
Author(s):  
C. G. Semple ◽  
J. A. Thomson
Keyword(s):  
Thyroid Nodule ◽  
Cushing’S Syndrome ◽  
Multiple Endocrine Neoplasia ◽  
Thyroid Nodules ◽  
Cushing Syndrome ◽  
Cushing's Syndrome ◽  
Graves Disease ◽  
Endocrine Neoplasia ◽  
Solitary Thyroid Nodule ◽  
Autonomous Thyroid Nodule

Abstract. Over a 20 year period 4 of 40 (10%) female patients with Cushing' syndrome also had a solitary thyroid nodule. In 3 cases this was an autonomous 'hot' nodule. In the same population only one case of presumed Graves' disease was seen. It is postulated that the association of autonomous thyroid nodule and Cushing's syndrome may represent a variant of multiple endocrine neoplasia.

Cushing's Syndrome Secondary to a Thymic Carcinoid Tumor Due to Multiple Endocrine Neoplasia Type 1

2011 ◽  
Vol 1 (-1) ◽  
pp. 1-16
Author(s):  
Ali A Ghazi ◽  
Azizollah Abbasi Dezfooli ◽  
Farzaneh Mohamadi ◽  
Seyed Vahid Yousefi ◽  
Alireza Amirbaigloo ◽  
...  
Keyword(s):  
Carcinoid Tumor ◽  
Cushing’S Syndrome ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Cushing's Syndrome ◽  
Thymic Carcinoid ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type ◽  
Thymic Carcinoid Tumor

Multiple endocrine neoplasia with Cushing's syndrome due to paraganglioma producing corticotropin-releasing factor and adrenocorticotropin

1986 ◽  
Vol 113 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Kozo Hashimoto ◽  
Shuso Suemaru ◽  
Teruhiko Hattori ◽  
Masanori Sugawara ◽  
Zensuke Ota ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Multiple Endocrine Neoplasia ◽  
Cushing's Syndrome ◽  
Corticotropin Releasing Factor ◽  
Pituitary Cells ◽  
Pancreatic Islet Cell ◽  
Cell Adenoma ◽  
Rare Type ◽  
Endocrine Neoplasia ◽  
Wet Weight

Abstract. A male patient with corticotropin-releasing factor (CRF) and adrenocorticotropin (ACTH)-producing syndrome is described. Soon after being referred to us the patient developed pneumonia, anaemia, oedema and respiratory distress, and died on the 24th day after admission. Autopsy and histology revealed that he had a rare type of multiple endocrine neoplasia (type 1 + paraganglioma) with a mediastinal paraganglioma, parathyroidal hyperplasia, pancreatic islet cell adenoma, duodenal multiple carcinoid tumours and adrenocortical nodular hyperplasia. It was not possible to examine the pituitary. The paraganglioma contained a large amount of immunoreactive (IR)-CRF (606 ng/g wet weight), IR-ACTH (59.4 ng/g wet weight), IR-human proopiomelanocortin n-terminal (1–76) peptide (hNT, 156.8 ng/g wet weight) and IR-β-lipotropin (β-LPH, 146.9 ng/g wet weight). The major IR-ACTH, β-LPH and IR-hNT were eluted at ACTH-(1–39), β-LPH and hNT marker positions, respectively. Big ACTH was not detected. IR-CRF eluted at the human CRF marker position on Sephadex G-75 chromatography and high performance liquid chromatography (HPLC). The IR-CRF fraction from the HPLC showed CRF bioactivity which paralleled that of synthetic human CRF in monolayer cultured rat anterior pituitary cells. Our results suggest that not only ACTH but CRF produced by the paraganglioma was responsible for the patient's Cushing's syndrome.

scholarly journals Cushing’s syndrome in multiple endocrine neoplasia type 1

2012 ◽  
Vol 76 (3) ◽  
pp. 379-386 ◽  
Author(s):  
William F. Simonds ◽  
Sarah Varghese ◽  
Stephen J. Marx ◽  
Lynnette K. Nieman
Keyword(s):  
Cushing’S Syndrome ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Cushing's Syndrome ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type

scholarly journals Frequency of Osteoporosis in Iatrogenic Cushing’s syndrome: Scenario of outpatient department in urban hospitals

2020 ◽  
Vol 31 (1) ◽  
pp. 18-21
Author(s):  
Tamanna Bahar ◽  
Shaila Rahman ◽  
Lilian Catherene Gomes ◽  
Mohammad Murad Hossain ◽  
Zulfia Zinat Chowdhury ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing Syndrome ◽  
Reference Population ◽  
Final Diagnosis ◽  
Cushing's Syndrome ◽  
Outpatient Department ◽  
Clinical Feature ◽  
Cross Sectional ◽  
Prevalence Of Osteoporosis ◽  
Iatrogenic Cushing’S Syndrome

Background: Cushing’s syndrome is caused by excessive activation of glucocorticoid receptor. Iatrogenic Cushing syndrome is the prevalent one world -wide .Patients with Cushing’s syndrome has a high prevalence of osteoporosis. Objective: To see the prevalence of osteoporosis in Iatrogenic Cushing’s syndrome patient. Method: This descriptive cross-sectional study included 211 diagnosed case of Cushing’s syndrome during the time period of December 2013 to December 2018 in outpatient department of Dhaka Medical College and Health and Hope Hospital. Final diagnosis was done on the basis of clinical feature, serum basal cortical level and BMD. We found male were prevalent one (56%).80.56% showed biochemical evidence of Cushing’s syndrome. BMD was done in 113 patients compared with a reference population by means of T score, 17.69% patient in osteoporotic range. Conclusion: The prevalence of osteoporosis and osteopenia is age and sex independent. Judicial use of steroid and co administration with calcium, bisphosphonate can prevent osteoporosis. Treatment with bisphosphonates should be considered in all patients (irrespective of age) with Cushing’s syndrome with a low BMD to reduce fracture. Bangladesh J Medicine Jan 2020; 31(1) : 18-21

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