Ten year alendronate use does not adversely affect bone quality compared to 5 years use: a human iliac crest biopsy study

2014 ◽  
Author(s):  
Norbert Hassler ◽  
Sonja Gamsjaeger ◽  
Birgit Hofstetter ◽  
Wolfgang Brozek ◽  
Barbara Misof ◽  
...  

PEDIATRICS ◽  
1967 ◽  
Vol 40 (4) ◽  
pp. 649-655
Author(s):  
Mark D. Cloutier ◽  
Alvin B. Hayles ◽  
B. Lawrence Riggs ◽  
Jenifer Jowsey ◽  
William H. Bickel

A case of idiopathic osteoporosis in a 12-year-old girl has been reported. Quantitative microradiographic studies of a biopsy specimen of iliac crest showed normal bone formation and an almost threefold increase in the level of bone resorption. The patient was observed without treatment, and a spontaneous clinical remission with roentgenographic improvement occurred. A second iliac crest biopsy specimen, obtained 15 months after the initial biopsy at a time when roentgenographic improvement was apparent, showed a return toward normal of the level of bone resorption. Metabolic balance studies conducted at this time showed that the patient was approximately in calcium balance. Because the majority of the previously reported cases have also exhibited spontaneous improvement, it is suggested that initially observation alone is indicated.



2000 ◽  
Vol 33 (4) ◽  
pp. 363-366 ◽  
Author(s):  
Francisco Dário Rocha Filho ◽  
Francisco Valdeci de Almeida Ferreira ◽  
Flávia de Oliveira Mendes ◽  
Fernanda Nogueira Holanda Ferreira ◽  
Alexandre Karbage ◽  
...  

Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients without detectable bone marrow fibrosis (wbmf = 18). There were no significant differences in clinical and blood parameters following treatment. All patients showed regression of hepatosplenomegaly.Our findings suggest that associated bone marrow fibrosis is transient and did not interfere in the evolution of treated patients.



1960 ◽  
Vol 80 (2) ◽  
pp. 391-397 ◽  
Author(s):  
J. S. Beck ◽  
B. E. C. Nordin


1986 ◽  
Vol 61 (7) ◽  
pp. 604 ◽  
Author(s):  
Michael R. Swenson ◽  
John F. Rothrock


Bone ◽  
1986 ◽  
Vol 7 (6) ◽  
pp. 427-430 ◽  
Author(s):  
J. Pødenphant ◽  
A. Gotfredsen ◽  
L. Nilas ◽  
H. Nørgaard ◽  
O. Brændstrup


1986 ◽  
Vol 61 (7) ◽  
pp. 604
Author(s):  
Stephen F. Hodgson


BMJ ◽  
1967 ◽  
Vol 1 (5541) ◽  
pp. 682-683 ◽  


1978 ◽  
Vol 64 (6) ◽  
pp. 621-630
Author(s):  
Mario Lise ◽  
Donato Nitti ◽  
Mario Fiorentino ◽  
Giangualberto Ricci ◽  
Eligio Grigoletto ◽  
...  

From December 1971 to December 1976 224 patients with Hodgkin's disease underwent diagnostic laparotomy and splenectomy under a multidisciplinary protocol of treatment. In 149/224 (66.5%) the clinical stage of the disease was confirmed, whereas in 75/224 (33.5%) it was modified after surgery. In 7.6% of the patients (17/224) there were postoperative complications. One patient died of myocardial infarction. The rate of complications in the last 100 cases was 5%. Preoperative patient selection, excluding those definitely in stage IV, is of relevance, and it can be done by iliac crest biopsy and laparoscopy. Although a better exploitation of some diagnostic procedures (lymphangiography, laparoscopy) and the expanding use of chemotherapy may reduce in the future the need for staging laparotomy and splenectomy, diagnostic laparotomy is still indicated for the selection and preparation of patients for radiation therapy in stages I, II and III.



2009 ◽  
Vol 6 (6) ◽  
pp. 639-644 ◽  
Author(s):  
Pierre D. Delmas ◽  
Annette Schlemmer ◽  
Evelyne Gineyts ◽  
Bente Riis ◽  
Claus Christiansen


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