JUVENILE OSTEOPOROSIS: REPORT OF A CASE INCLUDING A DESCRIPTION OF SOME METABOLIC AND MICRORADIOGRAPHIC STUDIES

A case of idiopathic osteoporosis in a 12-year-old girl has been reported. Quantitative microradiographic studies of a biopsy specimen of iliac crest showed normal bone formation and an almost threefold increase in the level of bone resorption. The patient was observed without treatment, and a spontaneous clinical remission with roentgenographic improvement occurred. A second iliac crest biopsy specimen, obtained 15 months after the initial biopsy at a time when roentgenographic improvement was apparent, showed a return toward normal of the level of bone resorption. Metabolic balance studies conducted at this time showed that the patient was approximately in calcium balance. Because the majority of the previously reported cases have also exhibited spontaneous improvement, it is suggested that initially observation alone is indicated.

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Review for "Division of an iliac crest bone biopsy specimen to allow histomorphometry, immunohistochemical, molecular analysis and tissue banking: technical aspect and applications"

10.1002/jbm4.10424/v1/review1 ◽

2020 ◽

Author(s):

LUCA DALLE CARBONARE

Keyword(s):

Molecular Analysis ◽

Biopsy Specimen ◽

Iliac Crest ◽

Tissue Banking ◽

Bone Biopsy ◽

Technical Aspect ◽

Iliac Crest Bone Biopsy

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Virtual Surgical Planning, Stereolitographic Models and CAD/CAM Titanium Mesh for Three-Dimensional Reconstruction of Fibula Flap with Iliac Crest Graft and Dental Implants

Journal of Clinical Medicine ◽

10.3390/jcm10091922 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1922

Author(s):

Carlos Navarro Cuéllar ◽

Manuel Tousidonis Rial ◽

Raúl Antúnez-Conde ◽

Santiago Ochandiano Caicoya ◽

Ignacio Navarro Cuéllar ◽

...

Keyword(s):

Bone Resorption ◽

Surgical Planning ◽

Iliac Crest ◽

Three Dimensional ◽

Titanium Mesh ◽

Iliac Crest Graft ◽

Virtual Surgical Planning ◽

Fibula Flap ◽

Dimensional Reconstruction ◽

Cad Cam

Mandibular reconstruction with fibula flap shows a 3D discrepancy between the fibula and the remnant mandible. Eight patients underwent three-dimensional reconstruction of the fibula flap with iliac crest graft and dental implants through virtual surgical planning (VSP), stereolitographic models (STL) and CAD/CAM titanium mesh. Vertical ridge augmentation and horizontal dimensions of the fibula, peri-implant bone resorption of the iliac crest graft, implant success rate and functional and aesthetic results were evaluated. Vertical reconstruction ranged from 13.4 mm to 10.1 mm, with an average of 12.22 mm. Iliac crest graft and titanium mesh were able to preserve the width of the fibula, which ranged from 8.9 mm to 11.7 mm, with an average of 10.1 mm. A total of 38 implants were placed in the new mandible, with an average of 4.75 ± 0.4 implants per patient and an osseointegration success rate of 94.7%. Two implants were lost during the osseointegration period (5.3%). Bone resorption was measured as peri-implant bone resorption at the mesial and distal level of each implant, with a variation between 0.5 mm and 2.4 mm, and with a mean of 1.43 mm. All patients were rehabilitated with a fixed implant prosthesis with good aesthetic and functional results.

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Bone marrow fibrosis (pseudo-myelofibrosis) in human kala-azar

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86822000000400005 ◽

2000 ◽

Vol 33 (4) ◽

pp. 363-366 ◽

Cited By ~ 7

Author(s):

Francisco Dário Rocha Filho ◽

Francisco Valdeci de Almeida Ferreira ◽

Flávia de Oliveira Mendes ◽

Fernanda Nogueira Holanda Ferreira ◽

Alexandre Karbage ◽

...

Keyword(s):

Bone Marrow ◽

Iliac Crest ◽

Histological Analysis ◽

Blood Parameters ◽

Bone Marrow Fibrosis ◽

Iliac Crest Biopsy ◽

The Third ◽

Kala Azar ◽

Reticulin Fibers ◽

Marrow Fibrosis

Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients without detectable bone marrow fibrosis (wbmf = 18). There were no significant differences in clinical and blood parameters following treatment. All patients showed regression of hepatosplenomegaly.Our findings suggest that associated bone marrow fibrosis is transient and did not interfere in the evolution of treated patients.

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Rates of New Bone Formation in Patients with Crush Fracture Osteoporosis

Clinical Science ◽

10.1042/cs0630153 ◽

1982 ◽

Vol 63 (2) ◽

pp. 153-160 ◽

Cited By ~ 11

Author(s):

J. Reeve ◽

J. R. Green ◽

R. Hesp ◽

Patricia Hulme

Keyword(s):

Bone Resorption ◽

Bone Formation ◽

Accretion Rate ◽

Positive Association ◽

Calcium Balance ◽

Tracer Technique ◽

New Bone Formation ◽

True Rate ◽

Exchange Processes

1. Calcium balances and formation rates of new bone measured with an improved tracer technique using 85Sr have been determined simultaneously in 21 patients with idiopathic osteoporosis and vertebral crush fractures. 2. A weak positive association was found between calcium balance and the kinetically measured calcium accretion rate, which is the sum of the true rate of bone formation and various long-term exchange processes. 3. The more negative balances were associated with significantly greater early loss of tracer taken up into bone by ‘accretion’, so that long-term (> 200 day) uptake was reduced. 4. This indicates that patients actively losing bone mineral have lower true rates of bone formation and higher rates of long-term exchange than their fellow patients who are more nearly in calcium equilibrium. 5. No statistically significant association was found between measured rates of bone resorption and calcium balance.

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