PBF is a component of the molecular signalling pathways that drive hyperplastic and neoplastic thyroid growth

2014 ◽  
Author(s):  
Vicki Smith ◽  
Martin Read ◽  
Rachel Watkins ◽  
Vikki Poole ◽  
Bhavika Modasia ◽  
...  
Keyword(s):  
Signalling Pathways ◽  
Molecular Signalling Pathways

Genetics

2016 ◽  
Author(s):  
Ana M. Valdes
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Complex Trait ◽  
Genetic Risk Factors ◽  
Underlying Disease ◽  
Epidemiological Studies ◽  
Signalling Pathways ◽  
Treatment Regimens ◽  
Tailored Treatment ◽  
Molecular Signalling Pathways

Epidemiological studies have demonstrated that osteoarthritis (OA) is a complex trait with numerous environmental and genetic risk factors. A great deal of effort has been spent elucidating these risk factors and progress has been made. It is clear however that the causes behind OA development and progression continue to remain largely elusive. Identification of those genes that, in conjunction with environmental factors, predispose to OA severity will lead to a better understanding of the mechanisms underlying disease development and thus promote improved health strategies for prevention. An understanding of the molecular signalling pathways involved in the initiation and progression of the disease will improve clinical diagnosis and help identify improved, tailored treatment regimens. This chapter focuses on these issues, exploring the heritability of OA, known genetic risk factors, and specific traits and outcomes studied in the genetics of OA.

Amino acid transportation, sensing and signal transduction in the mammary gland: key molecular signalling pathways in the regulation of milk synthesis

2020 ◽  
Vol 33 (2) ◽  
pp. 287-297
Author(s):  
Zhihui Wu ◽  
Jinghui Heng ◽  
Min Tian ◽  
Hanqing Song ◽  
Fang Chen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Milk Protein ◽  
Building Blocks ◽  
Branched Chain Amino Acids ◽  
Signalling Pathways ◽  
Recent Advances ◽  
Branched Chain ◽  
Molecular Signalling Pathways

AbstractThe mammary gland, a unique exocrine organ, is responsible for milk synthesis in mammals. Neonatal growth and health are predominantly determined by quality and quantity of milk production. Amino acids are crucial maternal nutrients that are the building blocks for milk protein and are potential energy sources for neonates. Recent advances made regarding the mammary gland further demonstrate that some functional amino acids also regulate milk protein and fat synthesis through distinct intracellular and extracellular pathways. In the present study, we discuss recent advances in the role of amino acids (especially branched-chain amino acids, methionine, arginine and lysine) in the regulation of milk synthesis. The present review also addresses the crucial questions of how amino acids are transported, sensed and transduced in the mammary gland.

Molecular signalling pathways in the cerebral cortex are required for retrieval of one-trial avoidance learning in rats

2000 ◽  
Vol 114 (1-2) ◽  
pp. 183-192 ◽  
Author(s):  
Daniela M Barros ◽  
Luciana A Izquierdo ◽  
Tadeu Mello e Souza ◽  
Patricia G Ardenghi ◽  
Patricia Pereira ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Avoidance Learning ◽  
Signalling Pathways ◽  
Molecular Signalling Pathways

scholarly journals Extracellular cAMP activates molecular signalling pathways associated with sperm capacitation in bovines

2017 ◽  
Vol 23 (8) ◽  
pp. 521-534 ◽  
Author(s):  
Carlos Agustín I. Alonso ◽  
Claudia E. Osycka-Salut ◽  
Luciana Castellano ◽  
Andreína Cesari ◽  
Nicolás Di Siervi ◽  
...  
Keyword(s):  
Signalling Pathways ◽  
Sperm Capacitation ◽  
Extracellular Camp ◽  
Molecular Signalling Pathways

Perfluorooctanoic acid (PFOA) affects distinct molecular signalling pathways in human primary hepatocytes

Toxicology ◽  
2015 ◽  
Vol 333 ◽  
pp. 53-62 ◽  
Author(s):  
Thorsten Buhrke ◽  
Eileen Krüger ◽  
Sophie Pevny ◽  
Manuela Rößler ◽  
Katja Bitter ◽  
...  
Keyword(s):  
Perfluorooctanoic Acid ◽  
Signalling Pathways ◽  
Primary Hepatocytes ◽  
Human Primary Hepatocytes ◽  
Molecular Signalling Pathways

Molecular signalling pathways involved in opioid tolerance and dependence

1990 ◽  
Vol 22 ◽  
pp. 379
Author(s):  
M. Parenti ◽  
D. Parolaro ◽  
G. Ceresoli ◽  
S. Del Monaco ◽  
C. Marcozzi ◽  
...  
Keyword(s):  
Signalling Pathways ◽  
Opioid Tolerance ◽  
Molecular Signalling Pathways

scholarly journals Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways

2017 ◽  
Vol 177 (5) ◽  
pp. 1322-1336 ◽  
Author(s):  
L. Michel ◽  
P. Reygagne ◽  
P. Benech ◽  
F. Jean‐Louis ◽  
S. Scalvino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Androgenetic Alopecia ◽  
Signalling Pathways ◽  
Gene Expression Alteration ◽  
Molecular Signalling Pathways
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