scholarly journals The association between Graves' disease and thyroid cancer: coincidence or causality? Case report

Author(s):  
Stefana Bilha ◽  
Ionut Repede ◽  
Alina Gatu ◽  
Radu Danila ◽  
Cristian Velicescu ◽  
...  
HORMONES ◽  
2015 ◽  
Author(s):  
Alfredo Campennì ◽  
Salvatore Giovinazzo ◽  
Lorenzo Curtò ◽  
Ernesto Giordano ◽  
Maria Trovato ◽  
...  

2019 ◽  
Vol 20 ◽  
pp. 1398-1401
Author(s):  
Konstantinos Sapalidis ◽  
Anastasios Papanastasiou ◽  
Nikolaos Michalopoulos ◽  
Stylianos Mantalovas ◽  
Dimitrios Giannakidis ◽  
...  

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Ogochukwu Okoli ◽  
Christine A Resta

Abstract A 59 year old woman presented with enlarged thyroid, weight loss, and hot flushes. She had previously been treated for a thyroid problem in 2013 but was lost to follow up. On exam, she had a diffusely enlarged thyroid gland, without distinct nodule. She had brisk DTR’s and mild tremor. Lab results confirmed hyperthyroidism:TSH <0.01 mIU/L (0.27 to 4.2) FT4 2.4 ng/dL (0.9 to 1.8) FT3 7.95 pg/mL (1.8 to 4.6). TSI was 307 % (<140%). Thyroid ultrasound showed a few sub-centimeter nodules, and 2 clinically significant nodules on the right--1.5 x 1.2 x 1.4 cm, cystic with calcifications; and 1.3 x 0.7 x 1.2 cm hypoechoic. I-123 thyroid uptake/scan showed 61% uptake and 2 right sided cold nodules. FNA biopsy showed medullary thyroid carcinoma (MTC) with staining positive for calcitonin and negative for thyroglobulin. CT thyroid showed no adenopathy. Serum calcitonin was 71 pg/mL (<5), and CEA was elevated 5.4 ng/mL (<2.5). Work up was negative for pheochromocytoma and hyperparathyroidism.After pretreatment with methimazole, she underwent total thyroidectomy with bilateral TE groove dissection. Surgical pathology confirmed MTC pT1b pN1a. She was started on levothyroxine therapy post operatively. Discussion There are multiple reports of thyroid carcinoma (papillary and follicular) in Graves disease, but rarely MTC.1 A recent systematic review reports only 21 total cases of MTC in patients with hyperthyroidism, of whom 15 had Graves disease.2 MTC is derived from C-cells from the thyroid gland rather than from follicular cells. TSI, therefore, should not influence development or growth of MTC. Coexistence of the two conditions is likely coincidental rather than causative. ConclusionThyroid nodules in patients with Graves should be worked up as there is a possibility of co-existing thyroid carcinoma. This patient had hyperthyroidism with cold nodules on nuclear scan corresponding to sonographic nodules. Based on these results, she had biopsy leading to diagnosis of MTC. Follow up surgery lead to diagnosis of MTC at earlier stage and provided treatment for both conditions. References1. Staniforth, J. U. etal (2016). Thyroid carcinoma in Graves’ disease: a meta-analysis. International Journal of Surgery, 27, 118-125. 2. Sapalidis, K. etal (2019). A Rare Coexistence of Medullary Thyroid Cancer with Graves Disease: A Case Report and Systematic Review of the Literature. The American journal of case reports, 20, 1398


Author(s):  
Rosa Marquez-Pardo ◽  
Lourdes Garcia-Garcia-Doncel ◽  
Mgloria Baena-Nieto ◽  
Manuel Cayon-Blanco ◽  
Rosario Lopez-Velasco ◽  
...  

2019 ◽  
Author(s):  
Georgios Boutzios ◽  
Eugenia Kotsifa ◽  
Nefeli Tomara ◽  
Eleni Koukoulioti ◽  
Zoe Garoufalia ◽  
...  

2012 ◽  
Vol 19 (1) ◽  
Author(s):  
B. L. Harry ◽  
M.L. Smith ◽  
J.R. Burton Jr ◽  
A. Dasari ◽  
S.G. Eckhardt ◽  
...  

2020 ◽  
Vol 13 (3) ◽  
pp. 1364-1367
Author(s):  
Afaf Albattah ◽  
Yahia Imam ◽  
Ahmed Osman Saleh ◽  
Khalid Ahmed ◽  
Tarek Aboursheid ◽  
...  

Thyroid cancer is the most frequent endocrine neoplasm in the general population. Common risk factors include gender, radiation exposure, and genetic backgrounds. The association of papillary thyroid cancer and celiac disease has frequently been reported in the literature; however, the association of papillary thyroid cancer and thalassemia trait is rare. Likewise, the association of thalassemia major and celiac disease is also rare. We hereby report a unique case of papillary thyroid cancer in a patient with celiac disease and thalassemia trait.


2020 ◽  
Vol 60 ◽  
pp. 614-618
Author(s):  
Suwardjo Suwardjo ◽  
Widya Surya Avanti ◽  
Ery Kus Dwianingsih ◽  
Wirsma Arif Harahap ◽  
Sumadi Lukman Anwar

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Carlos Velandia-Carrillo ◽  
Edwin Wandurraga-Sánchez ◽  
Diego Gómez-Abreo

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