Systematic review and meta-analysis of occurrence of other autoimmune diseases in autoimmune polyglandular syndrome type II and type III

2019 ◽  
Author(s):  
Greta Pham-Dobor ◽  
Laszlo Bajnok ◽  
Marin Gergics ◽  
Lilla Hanak ◽  
Peter Hegyi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Autoimmune Diseases ◽  
Meta Analysis ◽  
Syndrome Type ◽  
Type Ii ◽  
Type Iii ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type

scholarly journals Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

2004 ◽  
Vol 199 (9) ◽  
pp. 1285-1291 ◽  
Author(s):  
Martin A. Kriegel ◽  
Tobias Lohmann ◽  
Christoph Gabler ◽  
Norbert Blank ◽  
Joachim R. Kalden ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Autoimmune Diseases ◽  
Type I ◽  
Type Ii ◽  
Central Tolerance ◽  
Autoimmune Polyglandular Syndrome ◽  
Healthy Donors ◽  
Organ Specific ◽  
Autoimmune Polyglandular Syndrome Type

In autoimmune polyglandular syndromes (APS), several organ-specific autoimmune diseases are clustered. Although APS type I is caused by loss of central tolerance, the etiology of APS type II (APS-II) is currently unknown. However, in several murine models, depletion of CD4+ CD25+ regulatory T cells (Tregs) causes a syndrome resembling human APS-II with multiple endocrinopathies. Therefore, we hypothesized that loss of active suppression in the periphery could be a hallmark of this syndrome. Tregs from peripheral blood of APS-II, control patients with single autoimmune endocrinopathies, and normal healthy donors showed no differences in quantity (except for patients with isolated autoimmune diseases), in functionally important surface markers, or in apoptosis induced by growth factor withdrawal. Strikingly, APS-II Tregs were defective in their suppressive capacity. The defect was persistent and not due to responder cell resistance. These data provide novel insights into the pathogenesis of APS-II and possibly human autoimmunity in general.

scholarly journals True, True, Related? Autoimmune Polyglandular Syndrome Type II

2016 ◽  
Vol 129 (1) ◽  
pp. 38-41 ◽  
Author(s):  
Bridget P. Keenan ◽  
Swaytha Yalamanchi ◽  
Steven Hsu ◽  
Kelly Norsworthy ◽  
Todd T. Brown
Keyword(s):  
Syndrome Type ◽  
Type Ii ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type

scholarly journals Incessant Pericarditis With Recurrent Cardiac Tamponade as the Manifestation of Autoimmune Polyglandular Syndrome Type II

2020 ◽  
Vol 2 (10) ◽  
pp. 1536-1541 ◽  
Author(s):  
Ana V. Marinho ◽  
Rui Baptista ◽  
Luís Cardoso ◽  
Patrícia M. Alves ◽  
Sílvia Monteiro ◽  
...  
Keyword(s):  
Cardiac Tamponade ◽  
Syndrome Type ◽  
Type Ii ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type
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