Oral calcium loading test can predict the progression of hypercalcaemic primary hyperparathyroidism in patients with normocalcaemic hyperparathyroidism

2019 ◽  
Author(s):  
Kanapath Oungpasuk ◽  
Demetrios Hadjiminas ◽  
Neil Tolley ◽  
Stephen Robinson ◽  
Jeremy Cox
Keyword(s):  
Primary Hyperparathyroidism ◽  
Loading Test ◽  
Oral Calcium ◽  
Calcium Loading

Oral calcium loading test and response to diuretics in normal Taiwanese school children

1996 ◽  
Vol 10 (2) ◽  
pp. 175-179
Author(s):  
Yuan-Hao Chen ◽  
An-Jen Lee ◽  
Charng-Shing Lin ◽  
Chiung-Hui Chen ◽  
Russell W. Chesney ◽  
...  
Keyword(s):  
School Children ◽  
Loading Test ◽  
Oral Calcium ◽  
Calcium Loading

Oral calcium loading test and response to diuretics in normal taiwanese school children

1996 ◽  
Vol 10 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Yuan-Hao Chen ◽  
An-Jen Lee ◽  
Charng-Shing Lin ◽  
Chiung-Hui Chen ◽  
Russell W. Chesney ◽  
...  
Keyword(s):  
School Children ◽  
Loading Test ◽  
Oral Calcium ◽  
Calcium Loading

scholarly journals Oral Calcium-loading Test in Infancy, with Particular Reference to Idiopathic Hypercalcaemia

BMJ ◽  
1969 ◽  
Vol 1 (5642) ◽  
pp. 477-480 ◽  
Author(s):  
D. G. D. Barr ◽  
J. O. Forfar
Keyword(s):  
Loading Test ◽  
Oral Calcium ◽  
Calcium Loading

Diagnosis of normocalcemic hyperparathyroidism by oral calcium loading test

2003 ◽  
Vol 26 (4) ◽  
pp. 327-332 ◽  
Author(s):  
Philippe Hagag ◽  
I. Revet-Zak ◽  
N. Hod ◽  
T. Horne ◽  
M. J. Rapoport ◽  
...  
Keyword(s):  
Loading Test ◽  
Oral Calcium ◽  
Calcium Loading ◽  
Normocalcemic Hyperparathyroidism

scholarly journals Evaluation of a standardized short-time calcium suppression test in healthy subjects: interest for the diagnosis of primary hyperparathyroidism

2007 ◽  
Vol 157 (3) ◽  
pp. 351-357 ◽  
Author(s):  
Isabelle Titon ◽  
Anne Cailleux-Bounacer ◽  
Jean Pierre Basuyau ◽  
Hervé Lefebvre ◽  
Adeline Savouré ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Healthy Subjects ◽  
Plasma Calcium ◽  
Loading Test ◽  
Basal Serum ◽  
Calcium Loading ◽  
Basal Plasma ◽  
Suppression Test ◽  
Serum Pth ◽  
Short Time

Objective: The diagnosis of primary hyperparathyroidism (PHP) can be difficult in patients with normal plasma calcium or parathyroid hormone (PTH) levels. We perfected a standardized short-time i.v. calcium loading test in healthy controls (HC) and compared the results with those of patients with PHP. Methods: Sixteen HC received 0.33 mmol/kg calcium gluconate intravenously for 3 h. Plasma calcium and serum PTH levels (assayed with immunoluminescent sandwich methods) were measured before, at the end of the infusion and 3 h later. Results were compared with those of 16 PHP patients. Results: In HC, basal total plasma calcium (mean ± s.e.m.) was 2.33 ± 0.02 mmol/l. At the end of calcium loading, calcemia reached 3.21 ± 0.05 mmol/l and decreased to 2.94 ± 0.08 mmol/l 3 h later. In PHP patients, basal plasma calcium was 2.54 ± 0.03 mmol/l and reached similar values as in HC during the testing. Basal serum PTH levels were 32.5 ± 3.3 ng/l in HC and 86.9 ± 6.3 ng/l in PHP. At the end of calcium loading, they dropped to 8.8 ± 0.6 ng/l (HC) and to 31.4 ± 4.2 ng/l (PHP). Three hours later, they were 11.6 ± 0.8 and 39.8 ± 4.0 ng/l respectively. There was a cut-off in serum PTH values between the two groups at the end of calcium loading and 3 h later. Conclusion: The standardized short-time PTH suppression test appears reliable to differentiate healthy subjects from PHP whose serum PTH levels remain >14 and >23 ng/ml respectively at the end of loading and 3 h later. This well-tolerated and easily performed test could be used for the diagnosis of PHP in patients suspected for the disease despite the normality of some basal biological markers.

scholarly journals Oral Calcium-loading Test in Rickets and in Neonatal Tetany: Effect of Vitamin D

BMJ ◽  
1969 ◽  
Vol 3 (5663) ◽  
pp. 150-152 ◽  
Author(s):  
D. G. D. Barr ◽  
J. O. Forfar
Keyword(s):  
Vitamin D ◽  
Loading Test ◽  
Oral Calcium ◽  
Calcium Loading

scholarly journals Overlap of Pseudohypoparathyroidism and Primary Hyperparathyroidism in a Patient: Just a Coincidence?

2011 ◽  
Vol 3 (3) ◽  
pp. 128-130
Author(s):  
Ana Karena Neukirch ◽  
Christian Heckmann ◽  
Norbert Weyerbrock ◽  
Silke Günther ◽  
Cornelia Dotzenrath
Keyword(s):  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Female Patient ◽  
Oral Calcium ◽  
Albright’S Hereditary Osteodystrophy ◽  
Lower Position ◽  
The Right ◽  
Inactivating Mutation ◽  
Gnas1 Gene

ABSTRACT A 56-year-old female patient with the phenotype of Albright's hereditary osteodystrophy (AHO) and pseudohypoparathyroidism 1a (PHP) diagnosed in 1987 was shown to have a heterozygote inactivating mutation on the GNAS1 gene. The patient has been treated with oral calcium and vitamin D since diagnosis of PHP 1a and developed primary hyperparathyroidism (pHPT) in 2009. Ultrasound as well as 99Tcsestamibi could demonstrate a lesion in the right lower position. Intraoperatively, a solitary parathyroid adenoma was found and resected leading to a ‘normalization’ of PTH and calcium. This case highlight is the rare coincidence of PHP, AHO and pHPT.

Use of Oral Calcium Loading to Characterize the Hypercalciuria of Young Insulin-Dependent Diabetics*

1983 ◽  
Vol 57 (1) ◽  
pp. 94-100 ◽  
Author(s):  
MARY F. WITT ◽  
NEIL H. WHITE ◽  
JULIO V. SANTIAGO ◽  
YOSHIKI SEINO ◽  
LOUIS V. AVIOLI
Keyword(s):  
Oral Calcium ◽  
Calcium Loading ◽  
Insulin Dependent
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