scholarly journals Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period

Reproduction ◽  
2001 ◽  
pp. 593-600 ◽  
Author(s):  
R Li ◽  
L Hartley ◽  
L Robb
Keyword(s):  
Rat Uterus ◽  
Rnase Protection ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Genes Encoding ◽  
Interleukin 11 ◽  
Implantation Period ◽  
Receptor Alpha Chain

Studies in mice have shown that interleukin 11 (IL-11) signalling is required for female fertility. In the absence of IL-11, decidualization is markedly retarded and implantation fails. IL-11 acts via a heterodimeric receptor composed of a ligand-specific receptor alpha chain (IL-11R alpha) and the signalling moiety gp130. This study reports the cloning of genes encoding rat IL-11 and IL-11R alpha. RNase protection was used to demonstrate that expression of IL-11 is upregulated in the rat uterus at the initiation of implantation at 5.5 days after mating. Expression of the genes encoding the two receptor components, IL11Ra and gp130, did not change throughout the peri-implantation period. In situ hybridization studies revealed that, as in mice, expression of IL-11 was high in the primary decidual zone at the time of the attachment reaction, whereas IL11Ra was expressed throughout primary and secondary decidua. Conservation of the temporal and spatial expression of IL-11 and IL-11R alpha in the uterus of the mouse and rat during the peri-implantation period will facilitate future studies investigating the role of IL-11 in fertility.

scholarly journals T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans.

1985 ◽  
Vol 161 (5) ◽  
pp. 1255-1260 ◽  
Author(s):  
N Caccia ◽  
G A Bruns ◽  
I R Kirsch ◽  
G F Hollis ◽  
V Bertness ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Human T Cell ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

A cDNA clone encoding the alpha chain of the human T cell receptor was used in connection with somatic cell human-rodent hybrids to determine that the genes coding for the alpha chain are located on chromosome 14 in humans. In situ hybridization confirms this result and further localizes these genes to 14q11-14q12 on this chromosome. Since this region of chromosome has been shown to be nonrandomly involved in a number of T cell neoplasias, this assignment raises a number of interesting questions as to the possible involvement of the T cell receptor alpha chain genes in tumorigenesis.

Characterization and expression analysis of the chicken interleukin-11 receptor alpha chain

2005 ◽  
Vol 29 (4) ◽  
pp. 349-359 ◽  
Author(s):  
Tsuyoshi Kawashima ◽  
Shintaro Hojyo ◽  
Norihisa Nishimichi ◽  
Masaharu Sato ◽  
Masayoshi Aosasa ◽  
...  
Keyword(s):  
Expression Analysis ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Interleukin 11 ◽  
Receptor Alpha Chain

scholarly journals Ligand-induced assembly and activation of the gamma interferon receptor in intact cells.

1996 ◽  
Vol 16 (6) ◽  
pp. 3214-3221 ◽  
Author(s):  
E A Bach ◽  
J W Tanner ◽  
S Marsters ◽  
A Ashkenazi ◽  
M Aguet ◽  
...  
Keyword(s):  
Gamma Interferon ◽  
Beta Chain ◽  
Ifn Gamma ◽  
Intracellular Domain ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Gamma Receptor ◽  
Receptor Beta ◽  
Receptor Alpha Chain

Functionally active gamma interferon (IFN-gamma) receptors consist of an alpha subunit required for ligand binding and signal transduction and a beta subunit required primarily for signaling. Although the receptor alpha chain has been well characterized, little is known about the specific role of the receptor beta chain in IFN-gamma signaling. Expression of the wild-type human IFN-gamma receptor beta chain in murine L cells that stably express the human IFN-gamma receptor alpha chain (L.hgR) produced a murine cell line (L.hgR.myc beta) that responded to human IFN-gamma. Mutagenesis of the receptor beta-chain intracellular domain revealed that only two closely spaced, membrane-proximal sequences (P263PSIP267 and I270EEYL274) are required for function. Coprecipitation studies showed that these sequences are necessary for the specific and constitutive association of the receptor beta chain with the JAK-2 tyrosine kinase. These experiments also revealed that the IFN-gamma receptor alpha and beta chains are not preassociated on the surface of unstimulated cells but rather are induced to associate in an IFN-gamma-dependent fashion. A chimeric protein in which the intracellular domain of the beta chain was replaced by JAK-2 complemented human IFN-gamma signaling and biologic responsiveness in L.hgR. In contrast, a c-src-containing beta-chain chimera did not. These results indicate that the sole obligate role of the IFN-gamma receptor beta chain in signaling is to recruit JAK-2 into the ligand-assembled receptor complex.

Monoclonal antibodies against the human interleukin-11 receptor alpha-chain (IL-11Rα) and their use in studies of human mononuclear cells

2000 ◽  
Vol 241 (1-2) ◽  
pp. 43-59 ◽  
Author(s):  
Chrystel Blanc ◽  
Patricia Vusio ◽  
Karin Schleinkofer ◽  
Olivier Boisteau ◽  
Stefan Pflanz ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Mononuclear Cells ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Human Mononuclear Cells ◽  
Interleukin 11 ◽  
Receptor Alpha Chain

The gene for the human interleukin-11 receptor alpha chain locus is highly homologous to the murine gene and contains alternatively spliced first exons

1997 ◽  
Vol 29 (5) ◽  
pp. 753-766 ◽  
Author(s):  
Harshal H. Nandurkar ◽  
Lorraine Robb ◽  
Jillian K. Nicholl ◽  
Douglas J. Hilton ◽  
Grant R. Sutherland ◽  
...  
Keyword(s):  
Receptor Alpha ◽  
Alpha Chain ◽  
Chain Locus ◽  
Alternatively Spliced ◽  
Interleukin 11 ◽  
Receptor Alpha Chain

Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer

2005 ◽  
Vol 21 (6) ◽  
pp. 573-581 ◽  
Author(s):  
Nicole Deutscher ◽  
Frauke Bataille ◽  
Martin Hausmann ◽  
Stephan Kiessling ◽  
Gerhard Muller-Newen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Functional Expression ◽  
Colonic Epithelium ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Normal Colonic Epithelium ◽  
Interleukin 11 ◽  
Receptor Alpha Chain

A New Optical and Nuclear Dual-Labeled Imaging Agent Targeting Interleukin 11 Receptor Alpha-Chain

2007 ◽  
Vol 18 (2) ◽  
pp. 397-402 ◽  
Author(s):  
Wei Wang ◽  
Shi Ke ◽  
Sunkuk Kwon ◽  
Sasidhar Yallampalli ◽  
Arlin G. Cameron ◽  
...  
Keyword(s):  
Imaging Agent ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Interleukin 11 ◽  
Receptor Alpha Chain
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