scholarly journals Isoproterenol-induced Creatine Kinase Leakage in Langendorff-perfused Rat Heart Associated with Significant Myocardial Edema.

1998 ◽  
Vol 39 (4) ◽  
pp. 513-525 ◽  
Author(s):  
Keita ODASHIRO ◽  
Shin-ichi HIRAMATSU ◽  
Toru MARUYAMA ◽  
Yoshikazu KAJI ◽  
Shozo KANAYA ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Rat Heart ◽  
Myocardial Edema ◽  
Perfused Rat Heart

Cardiac performance and creatine kinase flux during inhibition of ATP synthesis in the perfused rat heart

1999 ◽  
Vol 277 (1) ◽  
pp. H308-H317 ◽  
Author(s):  
P. Mateo ◽  
V. Stepanov ◽  
B. Gillet ◽  
J.-C. Beloeil ◽  
J. A. Hoerter
Keyword(s):  
Creatine Kinase ◽  
Rat Heart ◽  
Mechanical Performance ◽  
Diastolic Pressure ◽  
Atp Synthesis ◽  
Cardiac Performance ◽  
Rate Pressure Product ◽  
Saturation Transfer ◽  
Perfused Rat Heart ◽  
Performance Rate

To study the relation among mitochondrial energy supply, cardiac performance, and energy transfer through creatine kinase (CK), two acute models of inhibition of ATP synthesis were compared in the isovolumic acetate-perfused rat heart. Similar impairments of mechanical performance (rate-pressure product, RPP) were achieved by various stepwise decreases in O2 supply ([Formula: see text] down to 20% of control) or by infusing CN (0.15–0.25 mM). The forward CK flux measured by saturation-transfer 31P NMR spectroscopy was 6.1 ± 0.4 mM/s in control hearts. Only after severe hypoxia ([Formula: see text] < 40% of control) did CK flux drop (to 1.9 ± 0.2 mM/s at[Formula: see text] = 25% of control) together with impaired systolic activity and a rise in end-diastolic pressure. In contrast, in mild hypoxia CK flux remained constant and similar to control (5.3 ± 0.5 mM/s, not significant) despite a twofold reduction in systolic activity. Similarly in all CN groups, constant CK flux was maintained for a threefold reduction in RPP, showing the absence of a relation between cardiac performance and global NMR-measured CK flux during mild ATP synthesis inhibition.

Regulation of energy flux through the creatine kinase reaction in vitro and in perfused rat heart

1984 ◽  
Vol 805 (4) ◽  
pp. 319-331 ◽  
Author(s):  
V.V. Kupriyanov ◽  
A.Ya. Steinschneider ◽  
E.K. Ruuge ◽  
V.I. Kapel'ko ◽  
M.Yu. Zueva ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Energy Flux ◽  
Rat Heart ◽  
Perfused Rat Heart ◽  
Kinase Reaction ◽  
Creatine Kinase Reaction

scholarly journals 31P NMR Detection of Subcellular Creatine Kinase Fluxes in the Perfused Rat Heart

2002 ◽  
Vol 277 (21) ◽  
pp. 18469-18476 ◽  
Author(s):  
Frederic Joubert ◽  
Jean-Luc Mazet ◽  
Philippe Mateo ◽  
Jacqueline A. Hoerter
Keyword(s):  
Creatine Kinase ◽  
Rat Heart ◽  
31P Nmr ◽  
Perfused Rat Heart

scholarly journals Pseudoketogenesis in the perfused rat heart.

1988 ◽  
Vol 263 (34) ◽  
pp. 18036-18042 ◽  
Author(s):  
G Fink ◽  
S Desrochers ◽  
C Des Rosiers ◽  
M Garneau ◽  
F David ◽  
...  
Keyword(s):  
Rat Heart ◽  
Perfused Rat Heart
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