scholarly journals Associations between Inflammatory Cells Infiltrating the Ethmoid Sinus Mucosa, and Nasal Polyp Size and Grade of Ethmoid Sinus Opacification on CT Images in Chronic Sinusitis

2009 ◽  
Vol 21 (3) ◽  
pp. 203-213
Author(s):  
Naotoshi IMAJIMA ◽  
So WATANABE ◽  
Atsuko FURUTA ◽  
Toshiyuki SHIMIZU ◽  
Naohiro YAMADA ◽  
...  
Keyword(s):  
Nasal Polyp ◽  
Chronic Sinusitis ◽  
Inflammatory Cells ◽  
Ct Images ◽  
Ethmoid Sinus ◽  
Polyp Size ◽  
Sinus Mucosa

scholarly journals Increased Expression of Glycoprotein 340 in the Ethmoid Sinus Mucosa of Patients With Chronic Sinusitis

2007 ◽  
Vol 133 (11) ◽  
pp. 1111 ◽  
Author(s):  
Tae Hoon Kim ◽  
Sang Hag Lee ◽  
Heung Man Lee ◽  
Hak Hyun Jung ◽  
Seung Hoon Lee ◽  
...  
Keyword(s):  
Chronic Sinusitis ◽  
Ethmoid Sinus ◽  
Sinus Mucosa

Diagnostic Value of Nasal Cytology in Chronic Rhinosinusitis Assessed by a Liquid-based Cytological Technique

2018 ◽  
Vol 32 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Wenyu She ◽  
Jun Yang ◽  
Chengshuo Wang ◽  
Luo Zhang
Keyword(s):  
Maxillary Sinus ◽  
Chronic Rhinosinusitis ◽  
Inflammatory Cell ◽  
Chronic Sinusitis ◽  
Inferior Turbinate ◽  
Inflammatory Cells ◽  
Diagnostic Value ◽  
Cell Counts ◽  
Nasal Cytology ◽  
Sinus Mucosa

Back ground: Nasal cytology has generally been employed as a useful diagnostic tool in the differentiation of rhinopathies. Objective The aim of this study was to assess the extent and diagnostic value of inflammation of nasal and paranasal sinus mucosa in chronic rhinosinusitis patients by employing a combination of nasal brushings and a liquid-based cytological technique. Methods Forty-eight patients with chronic sinusitis and 20 control subjects without any sign of sinusitis undergoing endoscopic surgery, although not all underwent endoscopic sinus surgery, were recruited to the study. Nasal cytology samples were collected from all subjects using nasal brush and processed a liquid-based cytological technique for evaluation of total and differential inflammatory cell counts. Biopsies were also taken from the inferior turbinates from its anterior margin in all subjects and from identical lateral maxillary sinus mucosa in patients with chronic sinusitis during surgery and routinely processed for staining and evaluation of inflammatory cells. Results Total and individual inflammatory cell counts in nasal brushings were significantly correlated with the respective inflammatory cell counts in biopsies obtained from the inferior turbinate (eosinophils: r = .519 and P = .016; neutrophils: r = .540 and P = .012; lymphocytes: r = .540 and P = .011) but not in biopsies obtained from the maxillary sinus. No correlation was observed between the inflammatory cells in biopsies from the inferior turbinate and biopsies from the maxillary sinus. The liquid-based cytological technique showed higher sensitivity (94.1%), specificity (76.9%), and positive predictive value (84.2%) for inflammation in the inferior turbinates than for inflammation in the maxillary sinus (sensitivity = 63.4% and positive predictive value = 63.4%). Conclusion Nasal cytology evaluated by use of nasal brushings processed by a liquid-based cytological technique is likely to have higher diagnostic value for the inflammatory response in noninfectious rhinitis than in chronic rhinosinusitis.

Ciliary Activity of Nasal Polyp and Mucosa in Chronic Sinusitis

1991 ◽  
Vol 5 (6) ◽  
pp. 215-218 ◽  
Author(s):  
Hitoshi Saito ◽  
Toshihito Tsubokawa
Keyword(s):  
Maxillary Sinus ◽  
Nasal Polyp ◽  
Chronic Sinusitis ◽  
Marked Decrease ◽  
Inferior Turbinate ◽  
Ciliary Activity ◽  
Ciliary Beating ◽  
Mucosal Cells ◽  
Sinus Mucosa

Ciliary activity of mucosal cells of nasal polyps and the maxillary sinus mucosa in chronic sinusitis cultured in vitro were measured by a photoelectric method. The findings were compared with those of normal maxillary sinus and inferior turbinate mucosae. The ciliary beating of edematous type of nasal polyp, 955 ± 130 beats/min (mean ± SD), did not differ significantly from the normal control, whereas both the duration and rate of ciliary beating were significantly decreased with cystic and fibrous type polyps. Ciliary activity in chronic sinusitis was significantly inhibited in the order of fibrous, purulent, and edematous types. The total area of ciliated mucosa also was decreased and varied with the type of chronic sinusitis, showing the most marked decrease with fibrous type. The ciliary activity in chronic sinusitis showed impairment with respect to both decreased ciliary rate of beating and reduced ciliated area.

Comparison of Inflammatory Cell Profile and Th2 Cytokine Expression in the Ethmoid Sinuses, Maxillary Sinuses, and Turbinates of Atopic Subjects with Chronic Sinusitis

1998 ◽  
Vol 118 (6) ◽  
pp. 804-809 ◽  
Author(s):  
ASMA KAMIL ◽  
OMAR GHAFFAR ◽  
FRANÇOIS LAVIGNE ◽  
RAME TAHA ◽  
PAOLO M. RENZI ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Maxillary Sinus ◽  
Chronic Sinusitis ◽  
Inferior Turbinate ◽  
Ethmoid Sinus ◽  
Interleukin 4 ◽  
Interleukin 5 ◽  
Sinus Mucosa ◽  
Maxillary Sinuses

Chronic sinusitis is a common disease characterized by persistent inflammation of the sinus mucosa. This study was undertaken to investigate immunopathologic findings in biopsy specimens from the ethmoid sinuses, maxillary sinuses, and inferior nasal turbinates of 14 allergic subjects with chronic sinusitis. The composition of the inflammatory infiltrate in the three tissue sites was examined by immunocytochemistry with anti-CD3 (total T cells), anti-CD4 (helper T cells), anti-CD8 (suppressor T cells), anti-MBP (eosinophils), antitryptase (mast cells), and antichymase (mast cells) antibodies. These revealed a significant increase in the T-cell helper/suppressor ratio and eosinophils in the ethmoid sinus mucosa compared with those in the maxillary sinus mucosa and the inferior turbinate. Eosinophil numbers were also higher in the maxillary sinus than in the inferior turbinate. Mast cells were present in significantly higher numbers in the ethmoid sinus and inferior turbinate biopsy sections than in the maxillary sinus. With antisense, radiolabeled riboprobes, we used in situ hybridization to examine the expression of interleukin-4 and interleukin-5 transcripts. The density of cells expressing interleukin-4 transcripts was significantly higher in the inferior turbinate biopsy sections than in those from the ethmoid and maxillary sinuses. In addition, the number of interleukin-4 mRNA—positive cells was higher in the ethmoid than in the maxillary sinus mucosa. The density of interleukin-5 mRNA—positive cells was significantly higher in the ethmoid and maxillary sinuses than in the inferior turbinate. The results of this study indicate (1) a more intense inflammatory response in the ethmoid sinus than in the maxillary sinus and inferior turbinate in allergic chronic sinusitis and (2) different inflammatory responses in the upper airways that are dependent on the anatomic site. These findings have potential implications in the design of new therapeutic interventions for allergic chronic sinusitis. (Otolaryngol Head Neck Surg 1998;118:804–9.)

Chronic Sinusitis: Comparison of Amoxicillin Concentration in Diseased versus Normal Mucosa

1996 ◽  
Vol 10 (5) ◽  
pp. 267-270
Author(s):  
Philip D. Kooiker ◽  
James M. Chow ◽  
James A. Stankiewicz ◽  
Ashok K. Singh
Keyword(s):  
Medical Management ◽  
Nasal Polyps ◽  
Chronic Sinusitis ◽  
Treatment Strategies ◽  
Inferior Turbinate ◽  
Normal Mucosa ◽  
Ethmoid Sinus ◽  
Current Medical ◽  
Number Of Patients ◽  
Sinus Mucosa

Despite advances in diagnostic and treatment strategies, chronic sinusitis remains both a common entity and a difficult disease to eradicate. Current medical management, which consists primarily of extended antibiotic therapy, is effective in temporarily alleviating symptoms, but is ineffective in a number of patients in eradicating the infection. One hypothesis for the failure of medical management may be due in part to inadequate penetration of antimicrobials into the diseased sinus mucosa. In order to investigate this, mucosal specimens consisting of nasal polyps and/or diseased anterior ethmoid mucosa were harvested from 19 patients with chronic sinusitis who were being treated with Augmentin® and analyzed for amoxicillin concentrations by high pressure liquid chromatography. A biopsy of normal-appearing mucosa from the inferior turbinate was obtained from the same patient and served as the control, and was analyzed for amoxicillin concentration. Nine of 14 (64%) patients who had polyps harvested had amoxicillin concentrations in the polyps less than the amoxicillin concentration in the inferior turbinate. Two of the 14 (14%) patients had amoxicillin concentrations in the polyps greater than the amoxicillin concentration in the inferior turbinate, and the remaining three patients had amoxicillin concentrations in the polyps similar to the amoxicillin concentration in the inferior turbinate, (P = 0.029). Five of the 10 (50%) patients who had diseased anterior ethmoid sinus mucosa had amoxicillin concentrations in the diseased anterior ethmoid sinus less than the amoxicillin concentration in the inferior turbinate. Two of the 10 (20%) patients had similar amoxicillin concentrations in the diseased anterior ethmoid sinus and in the inferior turbinate and three of 10 (30%) patients with diseased anterior ethmoid sinus mucosa had amoxicillin concentrations greater than the amoxicillin concentration in the inferior turbinate. (P = 0.3725). These data suggest that there is impaired penetration of amoxicillin into nasal polyps and possibly a trend toward impaired penetration of amoxicillin into diseased anterior ethmoid sinus mucosa.

Up-Regulation of Heparanase in the Ethmoid Sinus Mucosa of Patients with Chronic Sinusitis

2009 ◽  
Vol 23 (2) ◽  
pp. 130-134
Author(s):  
Tae Hoon Kim ◽  
Heung Man Lee ◽  
Seung Hoon Lee ◽  
Whan Choi ◽  
Ha Kyun Kim ◽  
...  
Keyword(s):  
Chronic Sinusitis ◽  
Ethmoid Sinus ◽  
Sinus Mucosa

scholarly journals Upregulation of Elafin and Cystatin C in the Ethmoid Sinus Mucosa of Patients With Chronic Sinusitis

2009 ◽  
Vol 135 (8) ◽  
pp. 771 ◽  
Author(s):  
Chang Whan Lee ◽  
Tae Hoon Kim ◽  
Heung Man Lee ◽  
Seung Hoon Lee ◽  
Sung Ho Lee ◽  
...  
Keyword(s):  
Cystatin C ◽  
Chronic Sinusitis ◽  
Ethmoid Sinus ◽  
Sinus Mucosa

D2-40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp

2007 ◽  
Vol 117 (3) ◽  
pp. 442-446 ◽  
Author(s):  
Tae Hoon Kim ◽  
Sang Hag Lee ◽  
Heung Man Lee ◽  
Seung Hoon Lee ◽  
Hak Hyun Jung ◽  
...  
Keyword(s):  
Nasal Polyp ◽  
Immunohistochemical Assessment ◽  
Sinus Mucosa
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