Increased Expression of Glycoprotein 340 in the Ethmoid Sinus Mucosa of Patients With Chronic Sinusitis

Chronic sinusitis is a common disease characterized by persistent inflammation of the sinus mucosa. This study was undertaken to investigate immunopathologic findings in biopsy specimens from the ethmoid sinuses, maxillary sinuses, and inferior nasal turbinates of 14 allergic subjects with chronic sinusitis. The composition of the inflammatory infiltrate in the three tissue sites was examined by immunocytochemistry with anti-CD3 (total T cells), anti-CD4 (helper T cells), anti-CD8 (suppressor T cells), anti-MBP (eosinophils), antitryptase (mast cells), and antichymase (mast cells) antibodies. These revealed a significant increase in the T-cell helper/suppressor ratio and eosinophils in the ethmoid sinus mucosa compared with those in the maxillary sinus mucosa and the inferior turbinate. Eosinophil numbers were also higher in the maxillary sinus than in the inferior turbinate. Mast cells were present in significantly higher numbers in the ethmoid sinus and inferior turbinate biopsy sections than in the maxillary sinus. With antisense, radiolabeled riboprobes, we used in situ hybridization to examine the expression of interleukin-4 and interleukin-5 transcripts. The density of cells expressing interleukin-4 transcripts was significantly higher in the inferior turbinate biopsy sections than in those from the ethmoid and maxillary sinuses. In addition, the number of interleukin-4 mRNA—positive cells was higher in the ethmoid than in the maxillary sinus mucosa. The density of interleukin-5 mRNA—positive cells was significantly higher in the ethmoid and maxillary sinuses than in the inferior turbinate. The results of this study indicate (1) a more intense inflammatory response in the ethmoid sinus than in the maxillary sinus and inferior turbinate in allergic chronic sinusitis and (2) different inflammatory responses in the upper airways that are dependent on the anatomic site. These findings have potential implications in the design of new therapeutic interventions for allergic chronic sinusitis. (Otolaryngol Head Neck Surg 1998;118:804–9.)

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Chronic Sinusitis: Comparison of Amoxicillin Concentration in Diseased versus Normal Mucosa

American Journal of Rhinology ◽

10.2500/105065896782159701 ◽

1996 ◽

Vol 10 (5) ◽

pp. 267-270

Author(s):

Philip D. Kooiker ◽

James M. Chow ◽

James A. Stankiewicz ◽

Ashok K. Singh

Keyword(s):

Medical Management ◽

Nasal Polyps ◽

Chronic Sinusitis ◽

Treatment Strategies ◽

Inferior Turbinate ◽

Normal Mucosa ◽

Ethmoid Sinus ◽

Current Medical ◽

Number Of Patients ◽

Sinus Mucosa

Despite advances in diagnostic and treatment strategies, chronic sinusitis remains both a common entity and a difficult disease to eradicate. Current medical management, which consists primarily of extended antibiotic therapy, is effective in temporarily alleviating symptoms, but is ineffective in a number of patients in eradicating the infection. One hypothesis for the failure of medical management may be due in part to inadequate penetration of antimicrobials into the diseased sinus mucosa. In order to investigate this, mucosal specimens consisting of nasal polyps and/or diseased anterior ethmoid mucosa were harvested from 19 patients with chronic sinusitis who were being treated with Augmentin® and analyzed for amoxicillin concentrations by high pressure liquid chromatography. A biopsy of normal-appearing mucosa from the inferior turbinate was obtained from the same patient and served as the control, and was analyzed for amoxicillin concentration. Nine of 14 (64%) patients who had polyps harvested had amoxicillin concentrations in the polyps less than the amoxicillin concentration in the inferior turbinate. Two of the 14 (14%) patients had amoxicillin concentrations in the polyps greater than the amoxicillin concentration in the inferior turbinate, and the remaining three patients had amoxicillin concentrations in the polyps similar to the amoxicillin concentration in the inferior turbinate, (P = 0.029). Five of the 10 (50%) patients who had diseased anterior ethmoid sinus mucosa had amoxicillin concentrations in the diseased anterior ethmoid sinus less than the amoxicillin concentration in the inferior turbinate. Two of the 10 (20%) patients had similar amoxicillin concentrations in the diseased anterior ethmoid sinus and in the inferior turbinate and three of 10 (30%) patients with diseased anterior ethmoid sinus mucosa had amoxicillin concentrations greater than the amoxicillin concentration in the inferior turbinate. (P = 0.3725). These data suggest that there is impaired penetration of amoxicillin into nasal polyps and possibly a trend toward impaired penetration of amoxicillin into diseased anterior ethmoid sinus mucosa.

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Up-Regulation of Heparanase in the Ethmoid Sinus Mucosa of Patients with Chronic Sinusitis

American Journal of Rhinology and Allergy ◽

10.2500/ajra.2009.23.3281 ◽

2009 ◽

Vol 23 (2) ◽

pp. 130-134

Author(s):

Tae Hoon Kim ◽

Heung Man Lee ◽

Seung Hoon Lee ◽

Whan Choi ◽

Ha Kyun Kim ◽

...

Keyword(s):

Chronic Sinusitis ◽

Ethmoid Sinus ◽

Sinus Mucosa

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Upregulation of Elafin and Cystatin C in the Ethmoid Sinus Mucosa of Patients With Chronic Sinusitis

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archoto.2009.97 ◽

2009 ◽

Vol 135 (8) ◽

pp. 771 ◽

Cited By ~ 7

Author(s):

Chang Whan Lee ◽

Tae Hoon Kim ◽

Heung Man Lee ◽

Seung Hoon Lee ◽

Sung Ho Lee ◽

...

Keyword(s):

Cystatin C ◽

Chronic Sinusitis ◽

Ethmoid Sinus ◽

Sinus Mucosa

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Bacteriology of the maxillary and ethmoid sinuses in chronic sinusitis

The Journal of Laryngology & Otology ◽

10.1017/s0022215100141866 ◽

1998 ◽

Vol 112 (9) ◽

pp. 845-848 ◽

Cited By ~ 14

Author(s):

Rong-San Jiang ◽

Chen-Yt Hsu ◽

Jinq-Wen JANG

Keyword(s):

Maxillary Sinus ◽

Staphylococcus Epidermidis ◽

Chronic Sinusitis ◽

Ethmoid Sinus ◽

Functional Endoscopic Sinus Surgery ◽

Sinus Surgery ◽

P Value ◽

Chi Square ◽

Chi Square Test ◽

Ethmoid Sinuses

AbstractThe bacteriology of chronic sinusitis was studied by using swab and mucosalspecimens from both the maxillary and ethmoid sinuses. The specimens of the maxillary sinus were taken through translabial antroscopy. The specimens of the ethmoid sinus were taken after removing the ethmoid bulla during functional endoscopic sinus surgery (FESS). Eighty-six samples of each type of specimen were collected. Among the maxillary sinus samples, the culture rate was 60.5 per cent from the swab specimens and 36 per cent from the mucosal specimens. Among the ethmoid sinus samples, the culture rate was 58.1 per cent from the swab specimens and 75.6 per cent from the mucosal. The p-value by the Chi-Square test is higher than 0.01 (p =0.015). As there were more isolates ofStaphylococcus epidermidisfrom the mucosal specimens, they are not a better choice of specimen for sampling the ethmoid sinus than a swab specimen.

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LYMPHOID FOLLICLE FORMATION IN SINUS MUCOSA OF CHRONIC SINUSITIS

Nippon Jibiinkoka Gakkai Kaiho ◽

10.3950/jibiinkoka.99.1662 ◽

1996 ◽

Vol 99 (11) ◽

pp. 1662-1675,1727 ◽

Cited By ~ 4

Author(s):

HIROSHI TSURUMARU

Keyword(s):

Chronic Sinusitis ◽

Lymphoid Follicle ◽

Sinus Mucosa

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Computed Tomography Study of Sinus Involvement in Ozena

American Journal of Rhinology ◽

10.2500/105065895781808810 ◽

1995 ◽

Vol 9 (5) ◽

pp. 281-284 ◽

Cited By ~ 2

Author(s):

Yoav P. Talmi ◽

Jacob Bar-Ziv ◽

David Cohen ◽

Yehuda Finkelstein ◽

Jona Kronenberg

Keyword(s):

Computed Tomography ◽

Ethmoid Sinus ◽

Atrophic Rhinitis ◽

Mucosal Atrophy ◽

Ciliary Motility ◽

Mucosal Disease ◽

Nasal Disease ◽

Symptom Complex ◽

Sinus Mucosa ◽

Maxillary Sinuses

Atrophic rhinitis or ozena is a chronic nasal disease characterized by formation of foul smelling nasal crusts with subsequent turbinate mucosal atrophy and resorption of the underlying bone. This symptom complex involves nasal and sinus mucosa with resultant mucosal atrophy, as well as reduced or absent mucocilliary function. The question of the presence of sinusitis in ozena is yet unanswered. Mucosal atrophy may lead to widely patent sinus ostia, but it may well be that the nasal mucosal disease also involves the sinus mucosa with reduced ciliary motility and ensuing sinusitis. We have undertaken a prospective CT study of 11 ozena patients in order to define the occurrence of sinusitis in this entity. These studies, corroborated in part by nasal endoscopies, demonstrate a 70% ethmoid sinus involvement. The sphenoid, frontal, and maxillary sinuses are not usually involved. Other CT criteria of ozena are described.

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