Role of IGF2 in the Study of Development and Evolution of Prostate Cancer

Prostate Cancer (PC) is commonly known as one of the most frequent tumors among males. A significant problem of this tumor is that in early stages most of the cases course as indolent forms, so an active surveillance will anticipate the appearance of aggressive stages. One of the main strategies in medical and biomedical research is to find non-invasive biomarkers for improving monitoring and performing a more precise follow-up of diseases like PC. Here we report the relevant role of IGF2 and miR-93-5p as non-invasive biomarker for PC. This event could improve current medical strategies in PC.

MEDICAL HUMANITIES AND ITS ROLE IN SHAPING ETHICS IN MEDICAL GRADUATES

Medicine as a field is unique in the sense that the skill to relate to people weighs heavier on the doctor than the skill required to practise it. Medical humanities is an interdisciplinary field that considers issues of health in the context of history, philosophy, social studies, and anthropology among others, enabling students to change their practice from “looking” to “seeing” the patient as a whole. Unfortunately, current medical training is focused on academics with students left on their own to acquire communication and ancillary skills. In the core medical curriculum, a structured training in medical humanities remains lacking. Herein, we discuss the need, student’s perspectives, and the approach going forward in the inculcation of medical humanities in the medical training with a particular focus on medical ethics.

Point of View about Corona Pandemic: An Approach towards Health Perspectives

It's been about a half year since there's been a word that's spread throughout the globe faster than wildfires, and it's not only the most talked-about topic, but also the most feared; yes, it's "crown." Hearing the word itself strikes dread in all individuals around the world. So what is this crown or COVID-19 truly? Coronavirus is an irresistible sickness brought about by the newfound strain of Covid, the SARS-CoV-2. Covid was accounted for from china in late December and early January from the province of Wuhan in China. Covid was found in the absolute most punctual known cases connected to Wuhan’s discount wet food market. The word crown got its fear of India on 30th January 2020 in Kerala. The patient was an understudy, concentrating in the city of source, and had returned to the nation because of the pandemic. Since January, this infection has been spreading and is accounted for everywhere in the world. Crown has become a dread that has not saved anybody from its effect. The everyday existence surprisingly around the globe has been affected since. This infection is a freak type of crown that is novel Covid covid19. Covid pandemic has instructed us that there are different exercises to be scholarly in the current pandemic circumstance. Crown has carried our thoughtfulness regarding how much progress should be around us. An alternate view and viewpoint have become known about our nation's current medical services plan. The establishment of medical care framework with medical services suppliers has come to stake. Ample opportunity has already passed that we investigate the current wellbeing administrations and strengthen them at the center level. Natural selection is one of the oldest adages in clinical research, and it has stayed consistent in situations like this. In the current circumstances, endurance has become an essential component.

Dear my Very Problematic Blood Glucose Meter: Adolescents' Experiences Self-Managing Type 1 Diabetes and their Psychosocial User Requirements Of Medical Technologies

<p>“Dear insulin pump. I love that you came into my life! You give me flexibility, confidence, and happiness.” “Dear my very problematic blood glucose meter. I wish I could let you go. I don't ask much from you, just correct readings and that you stop deciding to pack it in. You make me second guess myself and my health.” The difference between a loved and a despised medical device is stark. Adolescents with type 1 diabetes require medical devices that facilitate their self-management throughout every aspect of their lives, from school, to the sports field, to managing hypoglycaemia in the middle of the night. This research aims to describe adolescents’ experiences self-managing type 1 diabetes, and identify their psychosocial user requirements of medical technologies. Following a constructivist research paradigm, a range of predominantly qualitative and participatory design methods were employed with 16 adolescent and young adult participants with type 1 diabetes and nine health professionals. Methods included semi-structured interviews and a card-sort task to understand the psychosocial impacts of current medical devices. Cultural probes elicited: adolescents’ metaphors for managing diabetes, how they would like to manage their diabetes, the best and worst features of their devices, and the relationships they have with them. Undergraduate design students used secondary research and emergent psychosocial user requirements of medical devices to design blood glucose meters, lancets, storage solutions, and insulin pumps that resembled watches, jewellery, and smartphones, could be attached to a bike, or could glow at night. I used these designs to provide additional support for adolescents’ user requirements, demonstrate how they were of use to designers, and stimulate discussion with the adolescents. The adolescents with type 1 diabetes completed a participatory design workshop, designing blood glucose meters that challenged the ways in which medical devices currently draw attention. Findings were analysed using a constructivist approach to grounded theory, and psychosocial user requirements were developed. On average, current medical devices have positive psychosocial impacts on adolescents, with large positive impacts on users’ feelings of competence, followed by increased feelings of adaptability and self-esteem. However, some adolescent requirements remain unmet. Issues include the transition of responsibility for diabetes management from parent to adolescent, managing blood glucose while participating in everyday activities such as sports, managing attention, and developing acceptance of a long-term condition. Other issues stem from devices’ features, usability, reliability, and context of use. As research has indicated, the traditional health approach is about curing illness, but with diabetes, managing wellness is key. The person learns to fit diabetes around the rest-of-life. While it is pertinent that diabetes technologies are clinically effective, they should also be designed in alignment with adolescent psychosocial user requirements, taking into account not only their physical health, but also the ways and contexts in which adolescents go about their daily lives.</p>

Dear my Very Problematic Blood Glucose Meter: Adolescents' Experiences Self-Managing Type 1 Diabetes and their Psychosocial User Requirements Of Medical Technologies

<p>“Dear insulin pump. I love that you came into my life! You give me flexibility, confidence, and happiness.” “Dear my very problematic blood glucose meter. I wish I could let you go. I don't ask much from you, just correct readings and that you stop deciding to pack it in. You make me second guess myself and my health.” The difference between a loved and a despised medical device is stark. Adolescents with type 1 diabetes require medical devices that facilitate their self-management throughout every aspect of their lives, from school, to the sports field, to managing hypoglycaemia in the middle of the night. This research aims to describe adolescents’ experiences self-managing type 1 diabetes, and identify their psychosocial user requirements of medical technologies. Following a constructivist research paradigm, a range of predominantly qualitative and participatory design methods were employed with 16 adolescent and young adult participants with type 1 diabetes and nine health professionals. Methods included semi-structured interviews and a card-sort task to understand the psychosocial impacts of current medical devices. Cultural probes elicited: adolescents’ metaphors for managing diabetes, how they would like to manage their diabetes, the best and worst features of their devices, and the relationships they have with them. Undergraduate design students used secondary research and emergent psychosocial user requirements of medical devices to design blood glucose meters, lancets, storage solutions, and insulin pumps that resembled watches, jewellery, and smartphones, could be attached to a bike, or could glow at night. I used these designs to provide additional support for adolescents’ user requirements, demonstrate how they were of use to designers, and stimulate discussion with the adolescents. The adolescents with type 1 diabetes completed a participatory design workshop, designing blood glucose meters that challenged the ways in which medical devices currently draw attention. Findings were analysed using a constructivist approach to grounded theory, and psychosocial user requirements were developed. On average, current medical devices have positive psychosocial impacts on adolescents, with large positive impacts on users’ feelings of competence, followed by increased feelings of adaptability and self-esteem. However, some adolescent requirements remain unmet. Issues include the transition of responsibility for diabetes management from parent to adolescent, managing blood glucose while participating in everyday activities such as sports, managing attention, and developing acceptance of a long-term condition. Other issues stem from devices’ features, usability, reliability, and context of use. As research has indicated, the traditional health approach is about curing illness, but with diabetes, managing wellness is key. The person learns to fit diabetes around the rest-of-life. While it is pertinent that diabetes technologies are clinically effective, they should also be designed in alignment with adolescent psychosocial user requirements, taking into account not only their physical health, but also the ways and contexts in which adolescents go about their daily lives.</p>

Online Patient-Reported Platform Detects Trend of Increased COVID-19 Risk and Severity for Multiple Myeloma Patients on Active Lenalidomide-Based Therapy

Background: Since the start of the COVID-19 pandemic, "high-risk" patients, such as cancer patients, have had to reconsider their current medical treatments and other treatment alternatives to best minimize their risk for contracting COVID-19. Lenalidomide has immunomodulatory properties that stimulate the production of T-cells which help combat against infections which may include diseases such as COVID-19. In this abstract, we investigate whether lenalidomide protects multiple myeloma (MM) patients from contracting COVID-19 and whether lenalidomide decreases the severity of COVID-19 events (including hospital or intensive care unit [ICU] admissions, and need of assisted ventilation) for patients that contract the virus (PMID: 32950467, PMID: 32353254). Methods: MM patient data was collected through HealthTree ® Cure Hub for Multiple Myeloma (healthtree.org) and the relative risk was calculated to compare the risk of contracting COVID-19 between patients taking lenalidomide and those who were not at the time of contracting COVID-19. The odds ratio was calculated to measure lenalidomide's effect on the severity of COVID-19 if contracted. These events include whether a patient was hospitalized, had to go to the ICU, or required oxygen therapy. Results: There were 1,123 patients involved in comparing lenalidomide with the risk of contracting COVID-19, including patients that never tested positive for COVID-19. Surprisingly, our results showed that patients who are taking lenalidomide have a 10% higher risk for contracting COVID-19 than those who are not; however, these findings were insignificant. Furthermore, 40 patients were involved in investigating lenalidomide's effect on decreasing severe COVID-19 symptoms for MM patients. Our results showed that the odds of patients experiencing severe COVID-19 were 1.95 times more for those on lenalidomide than those who were not. Conclusions: Despite the insignificance of lenalidomide during COVID-19, our results indicated that taking lenalidomide may not be beneficial in lowering the risk for MM patients in contracting COVID-19. Furthermore, lenalidomide may also not decrease the severity of COVID-19 symptoms for MM patients that did contract COVID-19. Our results may help MM patients and their providers decide whether to continue their use of lenalidomide or to seek alternative treatment options. Disclosures Ahlstrom: Pfizer: Other: Patient Advisory; Janssen: Other: Patient Advisory; Takeda: Other: Patient Advisory; Bristol Myers Squibb: Other: Patient Advisory.

Prophylaxis of narcomany in pre-adolescent age

Drug use among adolescents and children is a current medical-pedagogical problem. In the prophylaxis and timely detection of drug users and other substances with narcotic effect among students of pre-university institutions are required to participate all persons involved in the education of children and adolescents: educators, pedagogues, parents, doctors. The detection of students using drugs and other substances with narcotic effect must be carried out through the collaboration of the management of pre-university and university educational institutions with narcological institutions, the offices for adolescents in polyclinics and the police [6].

Vitamin, Mineral Use and Participation in Exercise during the Coronavirus-19 Pandemic Period

Background: Deadly pandemic conditions, last seen in the 1918 Spanish Flu, similarly emerged in 2019 as coronavirus disease (COVID-19) in Wuhan, China. The metabolic status of the host, as influenced by current medical condition and lifestyle, appears to determine the clinical severity of COVID-19. Aim: The study aims to determine the rates of vitamin, mineral use, and exercise participation before the COVID-19 pandemic period and during the pandemic period. Methods: Eight hundred and twenty-two people living in the province of Izmir (Turkey) participated in the research. Using the questionnaire method, vitamin, mineral use, and participation in exercise were determined before the Covid-19 pandemic and during the ongoing one-year period. Frequency and Chi-Square Tests were used for statistical evaluation (p<0.05). Results: According to the results of the statistical analysis, significant increases were detected in the use of vitamins C, D, and zinc during the COVID-19 pandemic compared to before (p<0.05). It was determined that the frequency of participation in the exercise of the participants decreased significantly compared to the pre-COVID-19 pandemic period (p<0.05). Conclusion: Conclusion: As a result, it was observed that the frequency of participation in exercise decreased and the use of vitamins C, D, and zinc increased. During the ongoing COVID-19 pandemic, participation in healthy nutrition and exercise, which is known to contribute to a stronger immune system, is recommended as in normal conditions. Keywords: COVID-19, nutrition, exercise

Ghettos, Work and Health Immigration Policies and New Coronavirus in the Gioia Tauro Plain

In Italy, the new Coronavirus pandemic has dramatically highlighted the contradictions evident in the relations between the agri-food sector and the political-economic treatment of a work force whose productive contribution is nowadays perceived as highly necessary. In a short time, in fact, slowdowns encountered by the agricultural sector during pandemic endangered the subsistence’s conditions of thousands of rural workers. In this contribution, I’ll try to examine, in the background of the current medical emergency, the relation between reception policies, differential inclusion of migrant work force in the labour market and the production of urban and political marginality in Southern Italy, more specifically in the Gioia Tauro Plain.

Retreatment with Hyaluronic Acid Viscosupplementation in Knee Osteoarthritis: Agreement between EUROVISCO Guidelines and Current Medical Practice

Objectives This work studied if and how current clinical practice agrees with European Viscosupplementation Consensus Group (EUROVISCO) recommendations and how this agreement might be different according to physician’s specialization. In addition, this work aimed to identify key decision factors that practitioners consider in their decision to retreat or not a patient with hyaluronic acid viscosupplementation. Methods Practitioners have been invited by e-mail to participate in an online exercise on viscosupplementation retreatment. They received a fictional patient case at random among a set of predefined fictional cases. The platform asked the practitioner if he/she would retreat the patient with viscosupplementation or not. To take a decision, the practitioner could select questions among a list of predefined questions. Among them, some were related to criteria used in the EUROVISCO decision tree and others served as confounding factors. Results A total of 506 practitioners participated to the exercise, of which 399 gave their decision about the case assigned to them by the platform. The observed agreement between practitioner decisions and EUROVISCO recommendations was 58.89 ± 4.95% (95% confidence interval [CI]). Overall, the decision to retreat was taken in 47.87% of the cases, while the EUROVISCO guidelines follow-up would have led to 55.89% retreatment for the same cases ( P = 0.03). Conclusions In current practice, physicians tended to reinject their patients less than recommended, although EUROVISCO guidelines for viscosupplementation retreatment consider decision criteria that clearly correspond to those of practitioners in real life. These include the patients’ willingness to be treated or the patients’ perception of the effectiveness of the treatment.