Malignant Familial Adenomatous Polyposis treated by Laparoscopic Colectomy and Ileal Pouch Anal Anastomosis: a Case Report

2014 ◽  
Vol 23 (4) ◽  
pp. 445-448
Author(s):  
Florin Zaharie ◽  
George Ciorogar ◽  
Roxana Zaharie ◽  
Marcel Tantau ◽  
Cornel Iancu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Familial Adenomatous Polyposis ◽  
Ileal Pouch ◽  
Rectal Adenocarcinoma ◽  
Ileal Pouch Anal Anastomosis ◽  
Adenomatous Polyposis ◽  
Significant Family History ◽  
Rectal Polyps ◽  
Anal Anastomosis

The mean age of colorectal cancer in untreated familial adenomatous polyposis (FAP) is 39 years. We present the case of a 21-year-old patient with FAP and colorectal cancer. The patient was detected with significant family history: her mother died at age 45 with colon cancer; two uncles were diagnosed with colon cancer at the age of 40 and 43 and one aunt at the age of 45 with colon cancer and gastric cancer. The treatment was laparoscopic restorative proctocolectomy with total excision of the mesorectum and ileal pouch anal anastomosis completed with endoanal excision of inferior rectal polyps. The histopathological report described a well differentiated rectal adenocarcinoma T1N1aMx developed on a tubulo-villous adenoma located on the rectosigmoid jonction, the rest of the polyps with benign histology.

Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited

2006 ◽  
Vol 5 (3) ◽  
pp. 241-260 ◽  
Author(s):  
Alex Kartheuser ◽  
Pierre Stangherlin ◽  
Dimitri Brandt ◽  
Christophe Remue ◽  
Christine Sempoux
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Restorative Proctocolectomy ◽  
Ileal Pouch ◽  
Ileal Pouch Anal Anastomosis ◽  
Adenomatous Polyposis ◽  
Anal Anastomosis

Patterns of Adenoma Recurrence in Familial Adenomatous Polyposis Patients after Ileal Pouch-Anal Anastomosis

2015 ◽  
Vol 32 (6) ◽  
pp. 421-425 ◽  
Author(s):  
Adam L. Goldstein ◽  
Revital Kariv ◽  
Joseph M. Klausner ◽  
Hagit Tulchinsky
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Desmoid Tumor ◽  
Ileal Pouch ◽  
Medical Center ◽  
Colonic Polyps ◽  
Ileal Pouch Anal Anastomosis ◽  
Adenomatous Polyposis ◽  
Adenoma Recurrence ◽  
Duodenal Adenomas ◽  
Anal Anastomosis

Aim: This study aims at identifying the risk factors for the development of pre-cancerous pouch and/or cuff adenomas post ileal pouch anal anastomosis (IPAA) in familial adenomatous polyposis patients. Method: We retrospectively studied 59 patients operated at a single medical center during a 26-year period. Data on the timing and location of adenoma recurrence were recorded and possible correlations with patients' gender, age, presence of desmoid tumor, duodenal adenomas, type of anastomosis and number of operation stages were analyzed. Results: Thirty-five (59%) patients had at least one adenoma in either the cuff or the pouch, including 20 with isolated cuff adenomas, 4 with isolated pouch adenomas and 11 patients with adenomas in both the pouch and cuff. There was no significant correlation between gender, age at surgery, type of anastomosis, number of operative stages and the development of pouch or cuff adenomas. Desmoid tumor and pouch adenomas were significantly correlated with cuff adenomas formation. Duodenal adenomas were associated with pouch adenomas. There was some relationship between the development of cuff adenomas and the burden of colonic polyps, as well as the presence of duodenal adenomas. Conclusion: Adenomas in both the pouch and cuff commonly occur following IPAA, mandating lifelong annual endoscopic surveillance.

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