scholarly journals Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Fukuko Shimizu ◽  
Kenji Okami ◽  
Koji Ebisumoto ◽  
Daisuke Maki ◽  
Akihiro Sakai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Outpatient Setting ◽  
Endoscopic Examination ◽  
Unknown Primary ◽  
Tonsillar Carcinoma ◽  
Positron Emission

Background. The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinoma, and, in almost all those cases, carcinoma was detected using positron emission tomography/computed tomography and/or bilateral tonsillectomy. Methods and Results. We report the case of a 63-year-old male with bilateral tonsillar carcinoma detected using transoral endoscopic examination with narrow-band imaging (NBI). A biopsy of the bilateral tonsils revealed squamous cell carcinoma, which was demonstrated to be HPV-related using in situ hybridization and p16 immunohistochemistry. The patient was diagnosed as synchronous bilateral tonsillar carcinoma: T1 (2) N2b M0. He was treated with induction chemotherapy, bilateral radical tonsillectomy with neck dissection, and radiotherapy. Conclusion. To our knowledge, this is the first report of a synchronous bilateral tonsillar carcinoma detected using transoral NBI in the outpatient setting. Early diagnosis without the inspection under general anesthesia is beneficial for the patients with lymph node metastasis from unknown primary lesion.

Role of narrow-band imaging in detection of head and neck unknown primary squamous cell carcinoma

2018 ◽  
Vol 128 (9) ◽  
pp. 2060-2066 ◽  
Author(s):  
Marta Filauro ◽  
Alberto Paderno ◽  
Pietro Perotti ◽  
Filippo Marchi ◽  
Sabrina Garofolo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Unknown Primary ◽  
Primary Squamous Cell Carcinoma

scholarly journals Narrow band imaging under less-air condition improves the visibility of superficial esophageal squamous cell carcinoma

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Taro Iwatsubo ◽  
Ryu Ishihara ◽  
Yasushi Yamasaki ◽  
Yusuke Tonai ◽  
Kenta Hamada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Color Change ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Endoscopic Observation ◽  
Flat Type ◽  
The Mean ◽  
Visibility Score

Abstract Background The current virtual chromoendoscopy equipment cannot completely detect superficial squamous cell carcinoma (SCC) in the esophagus, despite its development in the recent years. Thus, in this study, we aimed to elucidate the appropriate air volume during endoscopic observation to improve the visibility of esophageal SCC. Methods This retrospective study included a total of 101 flat type esophageal SCCs identified between April 2017 and January 2019 at the Department of Gastrointestinal Oncology, Osaka International Cancer Institute. Video images of narrow band imaging (NBI) under both less-air and standard-air conditions were recorded digitally. Videos were evaluated by five endoscopists. Relative visibility between less-air and standard-air conditions of the brownish area, brownish color change of the epithelium, and dilated intrapapillary capillary loop (IPCL) were graded as 5 (definitely better under less-air condition) to 1 (definitely worse under less-air condition), with 3 indicating average visibility (equivalent to standard-air observation). Results The mean (standard deviation) visibility score of the brownish area, brownish color change of the epithelium, and dilated IPCLs under less-air condition were 3.94 (0.58), 3.73 (0.57), and 4.13 (0.60), respectively, which were significantly better than that under standard-air condition (p < 0.0001). Esophageal SCC evaluated as ≥ 4 in the mean visibility score of the brownish area, brownish color change of the epithelium, and dilated IPCLs accounted for 50% (51/101 lesions), 34% (34/101 lesions), and 67% (68/101 lesions), respectively. Conclusions The present results suggested that NBI with less air might improve the visibility of flat type esophageal SCC compared with NBI with standard air. Less-air NBI observation may facilitate the detection of flat type esophageal SCC. Trial registration The present study is a non-intervention trial.

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