Henoch-Schonlein Purpura

2020 ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Nephrotic Syndrome ◽  
Joint Pain ◽  
Laboratory Tests ◽  
Immunoglobulin A ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Key Points ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Key Points Henoch-Schönlein purpura (HSP) is the most common form of vasculitis in children.It is a small-vessel vasculitis mediated by immunoglobulin A–containing immune complexes and characterized by nonthrombocytopenic purpura, abdominal pain, arthralgia, and renal disease.Diagnosis of HSP is clinical, and no laboratory tests are specific for HSP.Treatment is supportive. Patients with severe abdominal and joint pain may be treated with steroids.Steroids do not prevent renal disease in patients with HSP.Patients with nephritic or nephrotic syndrome have a much higher risk of developing chronic kidney disease and should be referred to a nephrologist.

scholarly journals Koebner phenomenon in leukocytoclastic vasculitis: A case report and an updated review of the literature

2019 ◽  
Vol 7 ◽  
pp. 2050313X1985035
Author(s):  
Farah Kassam ◽  
Sabrina Nurmohamed ◽  
Richard M Haber
Keyword(s):  
Case Report ◽  
Leukocytoclastic Vasculitis ◽  
Immunoglobulin A ◽  
Small Vessel Vasculitis ◽  
Review Of The Literature ◽  
Henoch Schonlein Purpura ◽  
Koebner Phenomenon ◽  
Vessel Injury ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Leukocytoclastic vasculitis is the most common form of cutaneous vasculitis. It is a neutrophilic small vessel vasculitis resulting from the deposition of circulating immune complexes. Henoch-Schonlein purpura is a systemic type of leukocytoclastic vasculitis, characterized by immunoglobulin A-mediated blood vessel injury. We present a case of Henoch-Schonlein purpura in an adult female manifesting with a vasculitic rash with Koebner phenomenon.

Henoch-Schönlein purpura presenting with multiplex gastrointestinal manifestations and massive nephrotic syndrome in adulthood — a case report

Open Medicine ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. 521-524
Author(s):  
Farkas Klaudia ◽  
Molnár Tamás ◽  
Nagy Ferenc ◽  
Tiszlavicz László ◽  
Németh István ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Involvement ◽  
Gastrointestinal Symptoms ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Intravenous Cyclophosphamide ◽  
Rapid Improvement ◽  
Gastrointestinal Manifestations ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

AbstractHenoch-Schönlein purpura (HSP) is a systemic small vessel vasculitis mainly affecting children. We report a case of a 49-year-old woman with severe gastrointestinal and renal involvement of HSP. Endoscopy revealed more characteristic findings in the terminal ileum than in the gastric antrum. Histological examinations of the biopsy samples from the ileum, antrum, skin and kidney confirmed the diagnosis of HSP. Parenteral corticosteroid therapy led to a rapid improvement of the gastrointestinal symptoms, but because of the excessive proteinuria intravenous cyclophosphamide therapy had to be introduced.

scholarly journals A case of severe multifocal enteritis caused by unusual pattern of Henoch-Schönlein purpura

2014 ◽  
Vol 05 (01) ◽  
pp. 033-036
Author(s):  
Sung Bum Kim ◽  
Tae Nyeun Kim ◽  
Kook Hyun Kim
Keyword(s):  
Vascular Endothelium ◽  
Epigastric Pain ◽  
Oral Prednisone ◽  
Immunoglobulin A ◽  
Neutrophil Infiltration ◽  
Wall Thickening ◽  
Henoch Schonlein Purpura ◽  
Unusual Pattern ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

AbstractA 58-year-old male visited our hospital with a complaint of epigastric pain for 2 days. Physical examination showed no purpuric skin lesion. Abdominal computed tomography scan showed concentric segmental wall thickening of the duodenum. Esophagogastroduodenoscopy showed diffuse erythematous mucosa with exudates at the duodenum. On 4th hospital day, he developed hematochezia. colonoscopy showed circumferential erythematous mucosa with ulcerative hemorrhage at terminal ileum. The microscopic examination identified lots of neutrophil infiltration and deposition of immunoglobulin A (IgA) on vascular endothelium. Treatment with oral prednisone 40 mg was initiated. On 19th day, the patient developed hematuria and proteinuria. Histologic examination on renal biopsy showed focal proliferative glomerulonephritis and strongly positive IgA staining in the glomerular mesangium. Severe hemorrhagic mucosa on endoscopy, deposition of IgA on kidney and intestinal vascular endothelium suggests the diagnosis of Henoch–Schönlein purpura (HSP). We report severe multifocal enteritis caused by unusual pattern of HSP.

Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity

2017 ◽  
Vol 55 (3) ◽  
pp. 368-372
Author(s):  
Xiang Shi ◽  
Wen-Chao Li ◽  
Li-Jun Mo ◽  
Xiao-Hong Li ◽  
Yu-Zhen Luo ◽  
...  
Keyword(s):  
Acute Phase ◽  
Mean Platelet Volume ◽  
Area Under The Curve ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Platelet Volume ◽  
Convalescent Phase ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Therefore, our study aimed to evaluate the role of mean platelet volume concentrations in patients with Henoch-Schonlein purpura. Methods This study included 97 children with Henoch-Schonlein purpura and 120 healthy individuals as controls. Results Mean platelet volume concentrations were found to be significantly lower in Henoch-Schonlein purpura patients compared with healthy controls (8.1 ± 0.86 vs. 9.4 ± 0.81, P < 0.001). Similarly, significant negative correlations were observed between mean platelet volume and neutrophil count, platelet count and erythrocyte sedimentation rate in patients with Henoch-Schonlein purpura (r=−0.327, P = 0.001; r=−0.419, P < 0.001; r=−0.255, P = 0.012). Interestingly, mean platelet volume was significantly lower in the acute phase compared with the convalescent phase of Henoch-Schonlein purpura patients (7.8 ± 0.86 vs. 8.3 ± 0.77, P = 0.002). A cut-off value for mean platelet volume was 7.85 with area under the curve of 0.726 to identify acute phase vs. convalescent phase in patients with Henoch-Schonlein purpura. Mean platelet volume was independently associated with Henoch-Schonlein purpura in logistic regression analysis (odds ratio = 0.114, 95% confidence interval = 0.053–0.243, P < 0.001). Conclusions Our results suggest that mean platelet volume is inversely associated with disease in patients with Henoch-Schonlein purpura, and mean platelet volume may be a useful marker to identify active disease in Henoch-Schonlein purpura patients.

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