Depressed Neutrophil Chemotaxis in Infants with Cow's Milk and/or Soy Protein Intolerance

PEDIATRICS ◽  
1981 ◽  
Vol 67 (2) ◽  
pp. 264-268
Author(s):  
Helen L. Butler ◽  
William J. Byrne ◽  
Daniel J. Marmer ◽  
Arthur R. Euler ◽  
Russell W. Steele
Keyword(s):  
Soy Protein ◽  
Matched Control ◽  
Cow’S Milk ◽  
Neutrophil Chemotaxis ◽  
Cow's Milk ◽  
Random Migration ◽  
Clinical Recovery ◽  
Control Subjects ◽  
Protein Intolerance

Neutrophil chemotaxis and random migration were studied in 11 infants with active cow's milk and/or soy protein intolerance and in an additional four infants following clinical recovery. Results were compared to 15 age-matched control subjects. Infants with active intolerance exhibited depressed chemotaxis and enhanced random migration. The four recovered infants had values similar to those of control subjects.

Cow's Milk and Soy Protein Intolerance in Childhood

1982 ◽  
Vol 11 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Phillip M Kibort ◽  
Marvin E Ament
Keyword(s):  
Soy Protein ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Protein Intolerance

Soy Protein Intolerance: Four Patients With Concomitant Cow's Milk Intolerance

PEDIATRICS ◽  
1977 ◽  
Vol 59 (5) ◽  
pp. 730-732 ◽  
Author(s):  
Peter F. Whitington ◽  
Richard Gibson
Keyword(s):  
Soy Protein ◽  
Milk Protein ◽  
Soy Protein Isolate ◽  
Protein Isolate ◽  
Cow’S Milk ◽  
Disodium Cromoglycate ◽  
Rapid Weight Gain ◽  
Cow's Milk ◽  
Cow’S Milk Protein ◽  
Protein Intolerance

An infrequently encountered and poorly understood infantile disorder is gastrointestinal soy protein intolerance. Four patients who had intractable diarrhea of infancy and who failed to thrive were tested by oral challenge with soy protein isolate and were found to have soy protein intolerance. All four exhibited concomitant sensitivity to cow's milk protein. The response to challenge with soy protein included diarrhea, vomiting, hypotension, lethargy, and fever. These symptomns were immediate, of short duration, and occurred with each subsequent challenge dose. No patient exhibited cutaneous, pulmonary, or hematologic evidence of allergy although it was prominent in their families. A diet devoid of intact soy and cow's milk protein allowed symptomatic recovery and rapid weight gain. Oral disodium cromoglycate therapy was ineffective in one trial. Soy protein intolerance should be suspected in infants with diarrhea resistant to therapy with soy based formulas.

Comment on Soy Protein Intolerance

PEDIATRICS ◽  
1978 ◽  
Vol 61 (3) ◽  
pp. 502-503
Author(s):  
Pekka Kuitunen
Keyword(s):  
Soy Protein ◽  
Malabsorption Syndrome ◽  
Cow’S Milk ◽  
Gastrointestinal Disorders ◽  
Study Group ◽  
Milk Intolerance ◽  
Cow's Milk ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Protein Intolerance

With great interest I read the report by Whitington and Gibson on soy protein intolerance (Pediatrics 59:730, May 1977). In the Archives of Diseases in Childhood of May 1975, the study group for gastrointestinal disorders at the Children's Hospital, University of Helsinki, Finland, presented 54 infants with the malabsorption syndrome with cow's milk intolerance.1 Thirty-five of these 54 infants received soy protein as a substitute for cow's milk. Four of these 35 infants had concomitant soy protein intolerance.

JEJUNAL BIOPSY IN COW'S MILK PROTEIN INTOLERANCE

The Lancet ◽  
1978 ◽  
Vol 311 (8066) ◽  
pp. 722-723 ◽  
Author(s):  
J.C Vitoria ◽  
M.E Aranjuelo ◽  
J Rodriguez-Soriano
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Jejunal Biopsy ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Cow’S Milk Protein ◽  
Protein Intolerance

Soy Formula Doesn't Help Colic

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 299-300
Author(s):  
LASSE LOTHE ◽  
TOR LINDBERG ◽  
IRÉNE JAKOBSSON
Keyword(s):  
Adverse Reaction ◽  
Soy Protein ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

In Reply.— We fully agree with LeBlanc that there was no significant improvement when infants with colic were given a soy protein-based formula. As pointed out in the "Discussion," as many as 53% of the infants showed an adverse reaction to soy (corresponding figure for cow's milk formula was 71%). We also emphasized that these figures must be interpreted with caution. In fact, soy protein-based formula was a bad choice as placebo. A placebo substance should be a substance of no importance as an allergen in infancy and soy protein has been shown to be as antigenic as cow's milk proteins (Eastham EJ, et al: J Pediatr 1978;93:561).

Cow's Milk Protein Intolerance

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 461-462
Author(s):  
HAROLD I. LECKS
Keyword(s):  
At Risk ◽  
Diagnostic Procedure ◽  
Milk Protein ◽  
Rectal Mucosa ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Cow’S Milk Protein ◽  
Pragmatic Aspects ◽  
Protein Intolerance

In Reply.— The literature has been replete with discussions of cow's milk protein hypersensitivity relevant to its diagnosis as well as clinical patterns of presentation since the entity was initially described by M. Rubin 40 years ago. Drs Gilbertson and Bentley now suggest a comparatively simple diagnostic procedure for detecting cow's milk protein intolerance (hypersensitivity) by merely inspecting the rectal mucosa of the infant at risk. My criticism of their observations relates initially to the specificity of rectal mucosal vascularity changes, as well as to the pragmatic aspects of this diagnostic procedure.

Cow's Milk Protein Intolerance

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 461-461
Author(s):  
NICOLA J. GILBERTSON ◽  
DONALD BENTLEY
Keyword(s):  
Milk Protein ◽  
Rectal Mucosa ◽  
Cow’S Milk ◽  
Clinical Feature ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Cow’S Milk Protein ◽  
Protein Intolerance

To the Editor.— With regard to the diagnosis of cow's milk protein intolerance, we were interested by the findings of Kahn et al (Pediatrics 1985;76:880-884) and Dr Lecks' subsequent comments (Pediatrics 1986;78:378). A hitherto undescribed clinical feature that may contribute to the establishment of this diagnosis is the presence of hyperemia of the rectal mucosa in affected infants. Proctoscopy may readily be performed using a lubricated pediatric otoscope. The procedure is well tolerated, inexpensive, and takes only a few seconds.

In Vitro Cell-Mediated Immunologic Assay for Cow's Milk Allergy

PEDIATRICS ◽  
1980 ◽  
Vol 66 (3) ◽  
pp. 399-402
Author(s):  
Azaria Ashkenazi ◽  
Stanley Levin ◽  
Dalia Idar ◽  
Ayala Or ◽  
Ian Rosenberg ◽  
...  
Keyword(s):  
Normal Control ◽  
Acute Gastroenteritis ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Control Subjects ◽  
Β Lactoglobulin ◽  
In Infants And Children

The production of a lymphokine, the leukocyte-migration-inhibition factor (LIF), by peripheral blood lymphocytes in response to an in vitro challenge with bovine β-lactoglobulin was assayed in infants and children suspected of having allergy to cow's milk protein. of the patients studied, 24 had cow's milk allergy, 24 were normal control subjects, 18 had recovered from milk allergy, 10 were newborns, and 10 were babies suffering from acute gastroenteritis. All patients with milk allergy demonstrated significant LIF production in response to β-lactoglobulin (23.5% ± 6.4%). In the normal control subjects, LIF was 3.1% ± 4.3% (P < .0005). Only two of the 24 control subjects and two of the ten newborns had high-normal values bordering on the positive. None of the ten babies with acute gastroenteritis gave a positive response. Most of the children who had recovered from milk allergy and were ingesting cow's milk had negative assays. This cell-mediated immune assay is shown to be a reliable test for the diagnosis of sensitivity to milk protein in infants and children, and for determining dietary treatment and when this treatment can be safely terminated. In most cases, its use should eliminate the need for the potentially dangerous and ethically questionable provocation test, as well as the need for repeated intestinal biopsies.

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