Chronic Alveolar Hypoventilation Secondary to Macroglossia in the Beckwith-Wiedemann Syndrome

PEDIATRICS ◽  
1982 ◽  
Vol 70 (5) ◽  
pp. 695-697 ◽  
Author(s):  
Dean F. Smith ◽  
Frederick G. Mihm ◽  
Michael Flynn
Keyword(s):  
Pulmonary Hypertension ◽  
Airway Obstruction ◽  
Early Recognition ◽  
Upper Airway ◽  
Upper Airway Obstruction ◽  
Morbidity And Mortality ◽  
Airway Compromise ◽  
Alveolar Hypoventilation

Chronic upper airway obstruction has been shown to cause secondary reversible pulmonary hypertension. Many pathophysiologic processes can produce such obstruction. A 3-month-old child with Beckwith-Wiedemann syndrome who manifested chronic upper airway obstruction secondary to macroglossia is reported. Early recognition and therapy of airway compromise may decrease morbidity and mortality in this syndrome and others in which macroglossia is present.

scholarly journals Chronic Lymphocytic Leukemia as an Unusual Cause of Rapid Airway Compromise

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Adrian R. Bersabe ◽  
Joshua T. Romain ◽  
Erin E. Ezzell ◽  
John S. Renshaw
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Airway Obstruction ◽  
Head And Neck ◽  
Cervical Lymphadenopathy ◽  
Upper Airway ◽  
Lymphocytic Leukemia ◽  
Upper Airway Obstruction ◽  
Airway Compromise ◽  
History Of ◽  
Prevalent Form

Chronic Lymphocytic Leukemia (CLL) is the most prevalent form of non-Hodgkin’s lymphoma (NHL) in Western countries predominantly affecting adults over the age of 65. CLL is commonly indolent in nature but can present locally and aggressively at extranodal sites. Although CLL may commonly present with cervical lymphadenopathy, manifestation in nonlymphoid regions of the head and neck is not well described. CLL causing upper airway obstruction is even more uncommon. We describe a case of a patient with known history of CLL and stable lymphocytosis that developed an enlarging lymphoid base of tongue (BOT) mass resulting in rapid airway compromise.

scholarly journals Critical upper airway obstruction as the first symptom of acute myeloid leukemia - an anesthesiologic reminder

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Øyvind Bruserud ◽  
Øystein Wendelbo ◽  
Nils Vetti ◽  
Frederik Kragerud Goplen ◽  
Silje Johansen ◽  
...  
Keyword(s):  
Emergency Management ◽  
Airway Obstruction ◽  
Myeloid Leukemia ◽  
Early Recognition ◽  
Upper Airway ◽  
Upper Airway Obstruction ◽  
Airway Control ◽  
Computer Tomography Scan ◽  
Surgical Tracheotomy ◽  
Tomography Scan

Acute upper airway obstruction can be fatal. Early recognition of airway distress followed by diagnostic laryngoscopy and prompt intervention to secure airway control is crucial. We here present a 62-year old male patient who presented with cough and increasing respiratory distress for three weeks. Within the next 24 h, he developed symptoms of critical upper airway obstruction, endotracheal intubation was not possible, and an acute surgical tracheotomy was performed to retain patent airways. A computer tomography scan revealed severe laryngopharyngeal soft tissue thickening and upper airway obstruction caused by leukemic infiltration. He was diagnosed with acute leukemia and responded to induction chemotherapy. This case report points out the importance of establishing the diagnosis of critical upper airway obstruction in patients presenting with respiratory symptoms, and highlights the emergency management of airway obstruction due to malignant infiltration of leukemic blasts.

PULMONARY HYPERTENSION SECONDARY TO CHRONIC UPPER AIRWAY OBSTRUCTION

1968 ◽  
Vol 78 (5) ◽  
pp. 845-856 ◽  
Author(s):  
Reuben C. Setliff ◽  
Francis A. Puyau ◽  
Paul H. Ward
Keyword(s):  
Pulmonary Hypertension ◽  
Airway Obstruction ◽  
Upper Airway ◽  
Upper Airway Obstruction

Echocardiographic changes in children with pulmonary hypertension secondary to upper airway obstruction

1978 ◽  
Vol 93 (6) ◽  
pp. 931-936 ◽  
Author(s):  
Eliezer Nussbaum ◽  
Stephen S. Hirschfeld ◽  
Robert E. Wood ◽  
Thomas F. Boat ◽  
Carl F. Doershuk
Keyword(s):  
Pulmonary Hypertension ◽  
Airway Obstruction ◽  
Upper Airway ◽  
Upper Airway Obstruction

Combined central alveolar hypoventilation and upper airway obstruction

1978 ◽  
Vol 64 (1) ◽  
pp. 50-60 ◽  
Author(s):  
William W.L. Glenn ◽  
J.Bernard L. Gee ◽  
Douglas R. Cole ◽  
Wayne C. Farmer ◽  
Richard K. Shaw ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Upper Airway ◽  
Upper Airway Obstruction ◽  
Alveolar Hypoventilation

Hypersomnia with Periodic Breathing (An Acromegalic Pickwickian)

1978 ◽  
Vol 86 (6) ◽  
pp. ORL-897-ORL-903 ◽  
Author(s):  
Bruce J. Romanczuk ◽  
William P. Potsic ◽  
Joseph P. Atkins
Keyword(s):  
Airway Obstruction ◽  
Upper Airway ◽  
Periodic Breathing ◽  
Upper Airway Obstruction ◽  
Laryngeal Stenosis ◽  
Respiratory Disorders ◽  
Ondine’S Curse ◽  
Alveolar Hypoventilation ◽  
Respiratory Rhythms ◽  
Multiple Variants

The syndromes of Pickwickian, Ondine's curse, and primary alveolar hypoventilation are respiratory disorders manifesting increased sleepiness and irregular respiratory rhythms. These disorders are currently grouped as hypersomnia with periodic breathing (HPB). Polygraphic techniques have lead to a reasonable hypothesis as to the pathophysiology of the multiple variants of HPB. Discernible causes of HPB have been attributed to both central and peripheral factors. Peripheral factors encompass those conditions relating to upper airway obstruction. An acromegalic person suffering the HPB syndrome secondary to laryngeal stenosis is described.

scholarly journals Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db mice

2020 ◽  
Author(s):  
Huy Pho ◽  
Slava Berger ◽  
Carla Freire ◽  
Lenise J Kim ◽  
Mi-Kyung Shin ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Leptin Receptor ◽  
Minute Ventilation ◽  
Upper Airway ◽  
Nrem Sleep ◽  
Receptor Expression ◽  
Upper Airway Obstruction ◽  
Dorsomedial Hypothalamus ◽  
Obstructive Sleep ◽  
Alveolar Hypoventilation

ABSTRACTObesity can lead to recurrent upper airway obstruction (obstructive sleep apnea, OSA) during sleep as well as alveolar hypoventilation. We have previously shown that leptin stimulates breathing and treats OSA in leptin-deficient ob/ob mice and leptin-resistant diet-induced obese mice. Our previous data also suggest that leptin’s respiratory effects may occur in the dorsomedial hypothalamus (DMH). We selectively expressed leptin receptor LepRb in the DMH neurons of obese LepRb-deficient db/db mice (LepRb-DMH mice), which hypoventilate at baseline, and showed that intracerebroventricular injection of leptin in these animals increased inspiratory flow, tidal volume and minute ventilation during NREM sleep without any effect on the quality of NREM sleep or CO2 production. Leptin had no effect on upper airway obstruction in LepRb-DMH animals. We conclude that leptin stimulates breathing and treats obesity related hypoventilation acting on LepRb-positive neurons in the DMH.

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