ASSOCIATION OF EPSTEIN-BARR VIRUS WITH LEIOMYOSARCOMAS IN YOUNG PEOPLE WITH AIDS

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 347-347
Author(s):  
Maritza Navarro ◽  
I. Celine Hanson
Keyword(s):  
Smooth Muscle ◽  
Immune System ◽  
Epstein Barr Virus ◽  
Receptor Expression ◽  
Barr Virus ◽  
Ebv Infection ◽  
Smooth Muscle Tumors ◽  
Epstein Barr ◽  
Negative Controls ◽  
Hiv Negative

EBV was found in all smooth muscle tumors from the six HIV-infected cases, but not in smooth muscle tumors from HIV-negative controls. All tumors studied stained for CD21 (EBV receptor), but levels were higher on tumor cells from HIV-infected cases than controls. This suggests that perturbation of the immune system (as in AIDS) may increase the production of the EBV receptor and/or that EBV infection itself causes increased receptor expression. It is postulated that EBV may contribute to smooth muscle tumorigenesis in HIV infection and potentially in other immunosuppressed states.

Epstein-Barr virus–associated smooth muscle tumor presenting as a vulvar mass in an acquired immunodeficiency syndrome patient: a case report

2007 ◽  
Vol 17 (6) ◽  
pp. 1333-1337 ◽  
Author(s):  
S. Khunamornpong ◽  
K. Sukpan ◽  
P. Suprasert ◽  
S. Shuangshoti ◽  
J. Pintong ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Epstein Barr Virus ◽  
Smooth Muscle Tumor ◽  
Barr Virus ◽  
Ebv Infection ◽  
Smooth Muscle Tumors ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome ◽  
Vulvar Mass

Smooth muscle tumors in immunocompromised patients have a strong association with Epstein-Barr virus (EBV) infection. EBV-associated smooth muscle tumors (EBV-SMT) are considered as a distinct group of smooth muscle tumors with different clinicopathologic features from conventional smooth muscle tumors. A 31-year-old female patient presented with a 2-cm mass at the left labium majus, the clinical diagnosis of which was a Bartholin lesion. She had acquired immunodeficiency syndrome diagnosed 29 months before. Excisional biopsy revealed a cellular tumor composed of round- to spindle-shaped cells with mild to moderate nuclear atypia. The tumor cells were immunoreactive for smooth muscle actin and muscle actin (HHF-35). Evidence of EBV infection was confirmed by in situ hybridization for EBV-encoded small RNA-1. To our knowledge, this is the first case of EBV-SMT presenting as a vulvar mass. EBV-SMT should be included in the differential diagnoses of mesenchymal tumor in patients with immunosuppression and in the differential diagnoses of smooth muscle tumor in uncommon sites, including the vulva.

Benign and Malignant Smooth Muscle Tumors Containing Epstein-Barr Virus in Children with AIDS

1997 ◽  
Vol 27 (3-4) ◽  
pp. 303-314 ◽  
Author(s):  
Hal B. Jenson ◽  
Charles T. Leach ◽  
Kenneth L. McClain ◽  
Vijay V. Joshi ◽  
Brad H. Pollock ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Epstein Barr

Epstein-Barr Virus–Associated Smooth Muscle Tumor of the Iris in a Patient With Transplant: A Case Report and Review of the Literature

2009 ◽  
Vol 133 (8) ◽  
pp. 1238-1241
Author(s):  
Le Yu ◽  
Anthony J. Aldave ◽  
Ben J. Glasgow
Keyword(s):  
Smooth Muscle ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Smooth Muscle Tumor ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Muscle Tumor

Abstract Epstein-Barr virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr virus infection was confirmed by in situ hybridization for Epstein-Barr virus–encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr virus–associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.

scholarly journals Epstein–Barr Virus+ Smooth Muscle Tumors as Manifestation of Primary Immunodeficiency Disorders

2018 ◽  
Vol 9 ◽  
Author(s):  
Thomas Magg ◽  
Tilmann Schober ◽  
Christoph Walz ◽  
Julia Ley-Zaporozhan ◽  
Fabio Facchetti ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Primary Immunodeficiency ◽  
Epstein Barr Virus ◽  
Primary Immunodeficiency Disorders ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Epstein Barr

Epstein-Barr virus-associated smooth muscle tumors in children following solid organ transplantation: A review

2015 ◽  
Vol 19 (2) ◽  
pp. 235-243 ◽  
Author(s):  
Jacqueline Jossen ◽  
Jaime Chu ◽  
Hilary Hotchkiss ◽  
Birte Wistinghausen ◽  
Kishore Iyer ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Organ Transplantation ◽  
Epstein Barr Virus ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Epstein Barr

Epstein–Barr Virus in Smooth-Muscle Tumors

1995 ◽  
Vol 332 (25) ◽  
pp. 1719-1719 ◽  
Author(s):  
T. van Gelder ◽  
V.D. Vuzevski ◽  
W. Weimar
Keyword(s):  
Smooth Muscle ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Epstein Barr

Epstein-Barr Virus-Associated Smooth Muscle Tumor of the Basal Ganglia in an HIV+ Child: Case Report and Review of the Literature

2004 ◽  
Vol 7 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Shimareet Kumar ◽  
Mariarita Santi ◽  
Gilbert Vezina ◽  
Tena Rosser ◽  
Roma S. Chandra ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Basal Ganglia ◽  
Epstein Barr Virus ◽  
Smooth Muscle Tumor ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Mass Lesions ◽  
Muscle Tumor

We describe the clinicopathologic features of an Epstein-Barr virus (EBV)-associated smooth muscle tumor arising in the basal ganglia of a 10-year-old human immunodeficiency virus (HIV)-positive child. Only a few cases of intracranial smooth muscle tumors are reported in the literature and virtually all of these have been extra-axial, involving the dura or sinuses in HIV+ adults. Our case underscores the need to include an EBV-associated smooth muscle tumor in the differential diagnosis when evaluating intracranial mass lesions in immunodeficient children.

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