Cellular Signal Transduction Pathways for Anesthetic-induced Cardioprotection

2006 ◽  
Vol 3 (1) ◽  
pp. 93-94
Author(s):  
Zeljko J Bosnjak ◽  
David C Warltier
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathways ◽  
Cellular Signal Transduction ◽  
Cellular Signal

Investigating lipid signalling: it's all about finding the right PI

2008 ◽  
Vol 413 (1) ◽  
pp. e5-e6 ◽  
Author(s):  
Erik Nielsen
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathways ◽  
Lipid Kinase ◽  
Phosphatase Activities ◽  
Cellular Signal Transduction ◽  
Lipid Signalling ◽  
Lipid Phosphatase ◽  
Biochemical Journal ◽  
Cellular Signal ◽  
The Right

Phosphoinositides are well-known components of cellular signal transduction pathways and, more recently, have been shown to play important roles in organelle identity and targeting determinants for various cytosolic proteins. Conversion of PtdIns into its various phosphorylated derivatives, such as PtdIns4P and PtdIns(4,5)P2, is accomplished by a series of distinct lipid kinase and lipid phosphatase activities that are localized to specific subcellular membranes. As a result, production of distinct PtdIns forms is thought to be largely dependent on the access of these enzymes to their PtdIns or PtdInsP substrates. Interestingly, an investigation of two different PIS (PtdIns synthase) isoforms by Lofke et al. in this issue of the Biochemical Journal now indicates that the ability of PtdIns to be converted into downstream PtdInsPs may depend upon the PIS isoform from which it was synthesized.

scholarly journals Cellular Signal Transduction Pathways by Leptin in Colorectal Cancer Tissue: Preliminary Results

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Ewa Nowakowska-Zajdel ◽  
Urszula Mazurek ◽  
Malgorzata Stachowicz ◽  
Elzbieta Niedworok ◽  
Edyta Fatyga ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signal Transduction ◽  
Tnm Staging ◽  
Signal Transduction Pathways ◽  
Cancer Tissue ◽  
Cellular Signal Transduction ◽  
Molecular Tests ◽  
Genes Encoding ◽  
Cellular Signal ◽  
Cancer Tissues

The aim of the study was to analyse genes typing with the use of the oligonucleotide microarray technique (HG-U133A, Affymetrix) differentiating colorectal cancer tissues from tissues assessed histopathologically as healthy ones among a panel of 91 mRNA of genes encoding proteins involved in activation of cellular signal transduction pathways by leptin. Frozen tumor specimens from 11 colon cancer patients in various stages of clinical progression of the disease in an I–IV stage scale according to the TNM staging were used in molecular tests. Among the genes participating in the cascade of signal transfer in cell activated by leptin, the following ones: AKT1, STAT3, MCL1 were qualified as differentiating stage I and II and VEGFC, CCNDI the encoding genes respectively as differentiating III and IV stage neoplasm. It is necessary to extend studies of analysis of cellular signal transduction pathways by leptin in colorectal cancer initiation and transformation processes.

scholarly journals The regulatory circuits for hysteretic switching in cellular signal transduction pathways

FEBS Journal ◽  
2012 ◽  
Vol 279 (18) ◽  
pp. 3329-3337 ◽  
Author(s):  
Jeong-Rae Kim ◽  
Kwang-Hyun Cho
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathways ◽  
Cellular Signal Transduction ◽  
Regulatory Circuits ◽  
Cellular Signal
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