scholarly journals Management of Long QT Syndrome in Women Before, During, and After Pregnancy

2021 ◽  
Vol 15 ◽  
Author(s):  
Caroline Taylor ◽  
Bruce S Stambler
Keyword(s):  
Long Qt Syndrome ◽  
Postpartum Period ◽  
Torsades De Pointes ◽  
Close Monitoring ◽  
Cardiac Events ◽  
Long Qt ◽  
Life Threatening ◽  
Β Blocker ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

Congenital long QT syndrome (LQTS) is a primary genetic and electrical disorder that increases risk for torsades de pointes, syncope, and sudden death. Post-pubertal women with LQTS require specialized multidisciplinary management before, during, and after pregnancy involving cardiology and obstetrics to reduce risk for cardiac events in themselves and their fetuses and babies. The risk of potentially life-threatening events is lower during pregnancy but increases significantly during the 9-month postpartum period. Treatment of women with LQTS with a preferred β-blocker at optimal doses along with close monitoring are indicated throughout pregnancy and during the high-risk postpartum period.

scholarly journals Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome

Heart Rhythm ◽  
2011 ◽  
Vol 8 (8) ◽  
pp. 1207-1213 ◽  
Author(s):  
Alon Barsheshet ◽  
Derick R. Peterson ◽  
Arthur J. Moss ◽  
Peter J. Schwartz ◽  
Elizabeth S. Kaufman ◽  
...  
Keyword(s):  
Heart Rate ◽  
Long Qt Syndrome ◽  
Cardiac Events ◽  
Long Qt ◽  
Life Threatening ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

scholarly journals Congenital Long QT Syndrome in an Infant

2009 ◽  
Vol 9 (1) ◽  
pp. 111-112
Author(s):  
Aris Lacis ◽  
Inga Lace ◽  
Elina Teivane ◽  
Vita Knauere ◽  
Inguna Lubaua ◽  
...  
Keyword(s):  
Sudden Death ◽  
Long Qt Syndrome ◽  
Heart Rhythm ◽  
Torsades De Pointes ◽  
Cardiac Events ◽  
Long Qt ◽  
Heart Rhythm Disorders ◽  
Qt Syndrome ◽  
First Year Of Life ◽  
Congenital Long Qt Syndrome

Congenital Long QT Syndrome in an InfantLong QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by prolonged QT interval on ECG with prevalence close to 1/3000-1/5000. LQTS is characterized by the occurrence of syncopal episodes due to torsades de pointes ventricular tachycardia (VT) and by a high risk for sudden cardiac death among untreated patients (1, 2, 3). In 12% of patients with LQTS, sudden death is the first manifestation of the disease and only in 4% this happens in the first year of life (2). There is consensus that all symptomatic children with LQTS should be treated with β-blockers which are effective in preventing cardiac events and reducing mortality in 70%, but do not protect patients from sudden death completely (1,2,3,4). The prognosis is poor in untreated patients with annual mortality 20% and 10 year mortality up to 50% (1, 2). Here we present a case of relatively rare congenital heart rhythm disorders in an infant which required immediate treatment.

A rare indication of permanent pacemaker implantation in children: congenital long QT syndrome

2020 ◽  
Vol 30 (12) ◽  
pp. 1880-1881
Author(s):  
Mehmet Taşar ◽  
Nur Dikmen Yaman ◽  
Huseyin Dursin ◽  
Murat Şimşek ◽  
Senem Özgür
Keyword(s):  
Sudden Death ◽  
Long Qt Syndrome ◽  
Pacemaker Implantation ◽  
Torsades De Pointes ◽  
Permanent Pacemaker ◽  
Long Qt ◽  
Permanent Pacemaker Implantation ◽  
Qt Syndrome ◽  
Congenital Lqts ◽  
Congenital Long Qt Syndrome

AbstractCongenital Long QT Syndrome (LQTS) is a dangerous arrhythmic disorder that can be diagnosed in children with bradycardia. It is characterised by a prolonged QT interval and torsades de pointes that may cause sudden death. Long QT syndrome is an ion channelopathy with complex molecular and physiological infrastructure. Unlike the acquired type, congenital LQTS has a genetic inheritance and it may be diagnosed by syncope, stress in activity, cardiac dysfunction, sudden death or sometimes incidentally. Permanent pacemaker implantation is required for LQTS with resistant bradycardia even in children to resolve symptoms and avoid sudden death.

scholarly journals 102-06: Risk of Life-Threatening Cardiac Events in Some Long QT Syndrome Patients Treated with β-Blockers

EP Europace ◽  
2016 ◽  
Vol 18 (suppl_1) ◽  
pp. i85-i85
Author(s):  
Yitschak Biton ◽  
Ilan Goldenberg ◽  
Wojciech Zareba ◽  
Kutyifa Valentina ◽  
Arthur J. Moss
Keyword(s):  
Long Qt Syndrome ◽  
Cardiac Events ◽  
Long Qt ◽  
Life Threatening ◽  
Β Blockers ◽  
Qt Syndrome

Prenatal diagnosis and In Utero treatment of Torsades de Pointes associated with congenital long QT syndrome

2003 ◽  
Vol 91 (11) ◽  
pp. 1395-1398 ◽  
Author(s):  
Bettina F. Cuneo ◽  
Marc Ovadia ◽  
Janette F. Strasburger ◽  
Hui Zhao ◽  
Tom Petropulos ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Long Qt Syndrome ◽  
Torsades De Pointes ◽  
In Utero ◽  
Long Qt ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

Drug-induced torsades de pointes in one patient with congenital long QT syndrome

1996 ◽  
Vol 54 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Ming-Hsiung Hsieh ◽  
Shih-Ann Chen ◽  
Chern-En Chiang ◽  
Ching-Tai Tai ◽  
Shih-Huang Lee ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Torsades De Pointes ◽  
Long Qt ◽  
Drug Induced ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

scholarly journals Effectiveness and Limitations of β-Blocker Therapy in Congenital Long-QT Syndrome

Circulation ◽  
2000 ◽  
Vol 101 (6) ◽  
pp. 616-623 ◽  
Author(s):  
Arthur J. Moss ◽  
Wojciech Zareba ◽  
W. Jackson Hall ◽  
Peter J. Schwartz ◽  
Richard S. Crampton ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Long Qt ◽  
Blocker Therapy ◽  
Β Blocker ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

scholarly journals TRIGGER-SPECIFIC RISK FACTORS FOR CARDIAC EVENTS IN PATIENTS WITH THE CONGENITAL LONG-QT SYNDROME TYPE 2

2010 ◽  
Vol 55 (10) ◽  
pp. A130.E1215
Author(s):  
James A. Kim ◽  
Arthur J. Moss ◽  
Coeli M. Lopes ◽  
Scott McNitt ◽  
Jennifer L. Robinson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Long Qt Syndrome ◽  
Syndrome Type ◽  
Cardiac Events ◽  
Long Qt ◽  
Specific Risk ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome
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