Poly(Methacrylic Acid-g-Ethylene Glycol) Hydrogels as pH Responsive Biomedical Materials

1993 ◽  
Vol 331 ◽  
Author(s):  
Cristi L. Bell ◽  
Nicholas A. Peppas
Keyword(s):  
Hydrogen Bonding ◽  
Ethylene Glycol ◽  
Methacrylic Acid ◽  
Swelling Behavior ◽  
Ph Responsive ◽  
Responsive Membranes ◽  
Swelling Studies ◽  
Environmentally Sensitive ◽  
Responsive Hydrogels ◽  
Complexation Equilibrium

AbstractNovel graft copolymeric, pH responsive hydrogels have been synthesized by solution polymerization. Poly(methacrylic acid-g-ethylene glycol) hydrogels exhibit reversible complexation as a function of pH because of hydrogen bonding between the PEG grafts and the PMAA main chains. These gels are being developed as pH responsive membranes for use in biomedical applications. ATR-FTIR results indicate that there is hydrogen bonding occurring in membranes swollen under conditions favorable for complexation. Equilibrium swelling studies have shown that the pH of the surrounding environment has a significant effect on the swelling behavior of these membranes. The swelling behavior has also been shown to respond rapidly to changing pH conditions. P(MAA-g-EG) membranes also show pH sensitive permeability toward solutes as a result of this environmentally sensitive swelling.

Carboxylic acid modified pH-responsive composite polymer particles

2019 ◽  
Vol 39 (7) ◽  
pp. 671-678
Author(s):  
Nur E. Jannat ◽  
Md. Ashraful Alam ◽  
M.A. Rahman ◽  
M.M. Rahman ◽  
M.K. Hossain ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Methacrylic Acid ◽  
Ph Value ◽  
Ethylene Glycol Dimethacrylate ◽  
Glycol Dimethacrylate ◽  
Ph Responsive ◽  
Composite Polymer ◽  
Polymer Particles ◽  
Ph Values ◽  
Composite Polymer Particles

Abstract pH-responsive polymers are attracting much interest from researchers because of their wide application potentials in areas like biosensor, bioseparator, bioreactor, biocatalysis, drug delivery, and water treatments. In this investigation a two-step process is evaluated to prepare carboxyl(–COOH) functional submicrometer-sized pH-responsive composite polymer particles. First, submicrometer-sized polystyrene (PS) particles are prepared by a modified conventional dispersion polymerization. In the second step, PS/poly(methacrylic acid-acrylamide-ethylene glycol dimethacrylate) [PS/P(MAA-AAm-EGDMA)] composite polymer particles are synthesized by seeded co-polymerization of methacrylic acid, acrylamide, and ethylene glycol dimethacrylate in the presence of PS seed particles. The size distributions and morphologies analyzed by electron micrographs suggested that seeded copolymerization smoothly occurred without formation of any secondary tiny copolymer particles. The surface composition and functionality are confirmed by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance. The hydrodynamic diameter increased with the increase in pH values as part of the carboxyl groups are deprotonated, which favored the swelling of copolymer layer formed around the surface of PS particles. The adsorption of cationic and anionic surfactants at two different pH values showed that adsorption of cationic surfactant is favored at higher pH value whereas that of anionic surfactant is favored at lower pH value.

pH-Responsive Coassembly of Oligo(ethylene glycol)-Coated Gold Nanoparticles with External Anionic Polymers via Hydrogen Bonding

Langmuir ◽  
2017 ◽  
Vol 33 (22) ◽  
pp. 5537-5544 ◽  
Author(s):  
Yu Torii ◽  
Naotoshi Sugimura ◽  
Hideyuki Mitomo ◽  
Kenichi Niikura ◽  
Kuniharu Ijiro
Keyword(s):  
Gold Nanoparticles ◽  
Hydrogen Bonding ◽  
Ethylene Glycol ◽  
Ph Responsive ◽  
Anionic Polymers
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