STUDYING REACTIVITY RATIOS AND PHYSICAL PROPERTIES OF METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER

2015 ◽  
Vol 53 (2) ◽  
Author(s):  
Tran Vu Thang ◽  
Pham Thi Thu Ha ◽  
Nguyen Van Khoi ◽  
Nguyen Van Manh ◽  
Pham Thi Thu Trang
Keyword(s):  
Physical Properties ◽  
Methacrylic Acid ◽  
Ethyl Acrylate ◽  
Reactivity Ratios ◽  
Acrylate Copolymer

scholarly journals Copolymerization Parameters of 2-(N-Phthalimido) ethyl Methacrylate with Different Vinyl Monomers

2011 ◽  
Vol 8 (1) ◽  
pp. 17-24
Author(s):  
A. A. Aly ◽  
H. M. Ammar ◽  
A.A Khalil
Keyword(s):  
Antimicrobial Activity ◽  
Ir Spectroscopy ◽  
Methacrylic Acid ◽  
Methyl Acrylate ◽  
Ethyl Acrylate ◽  
Reactivity Ratios ◽  
Vinyl Monomers ◽  
Monomer Reactivity Ratios ◽  
Ethyl Methacrylate ◽  
Bacteria And Fungi

2-(N-phthalimido)ethyl methacrylate was prepared by the reaction of methacrylic acid with N-(2-hydroxyethyl)phthalimide in presence of N,N?-dicyclohexylcarbodiimide. The monomer reactivity ratios for copolymerization reactions of 2-(N-phthalimido)ethyl methacrylate with methyl acrylate, ethyl acrylate, butyl acrylate and styrene, respectively, in solution with azobisisobutyronitrile (AIBN) as initiator, were estimated by nitrogen analysis. The structure of the copolymers was investigated by IR spectroscopy. The Q and e values for 2-(N-phthalimido)ethyl methacrylate were calculated. Some of the synthesized polymers were tested for their antimicrobial activity against bacteria and fungi.

scholarly journals Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid–Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2023
Author(s):  
Omar Rodrigo Guadarrama-Escobar ◽  
Ivonne Sánchez-Vázquez ◽  
Pablo Serrano-Castañeda ◽  
German Alberto Chamorro-Cevallos ◽  
Isabel Marlen Rodríguez-Cruz ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Methacrylic Acid ◽  
Encapsulation Efficiency ◽  
Ethyl Acrylate ◽  
Water Volume ◽  
In Vivo Model ◽  
In Vivo Evaluation ◽  
Acrylate Copolymer ◽  
Screening Experiments

The methacrylic acid–ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume, time, and stirring speed, while size, PDI, zeta potential, and encapsulation efficiency were the response variables analyzed. A design of screening experiments was carried out to subsequently perform the optimization of the nanoparticle preparation process. The optimal formulation was characterized through the dependent variables size, PDI, zeta potential, encapsulation efficiency and drug release profiles. In vivo tests were performed in Wistar rats previously induced with diabetes by administration of streptozotocin. Once hyperglycemia was determined in rats, a suspension of nanoparticles loaded with glibenclamide was administered to them while the other group was administered with tablets of glibenclamide. The optimal nanoparticle formulation obtained a size of 18.98 +/− 9.14 nm with a PDI of 0.37085 +/− 0.014 and a zeta potential of −13.7125 +/− 1.82 mV; the encapsulation efficiency was of 44.5%. The in vivo model demonstrated a significant effect (p < 0.05) between the group administered with nanoparticles loaded with glibenclamide and the group administered with tablets compared to the group of untreated individuals.

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