RESULTS OF EXPERIMENTAL STUDIES OF THE CHILDREN’S AXIAL PUMP «DON-3»

Aim.To evaluate the functioning of an implantable pediatric axial pump «DON-3» for bypassing the left ventricle of the heart in experiments on sheep.Materials and methods. Five sheeps at the age of 12–18 months performed paracorporeal installation of the children’s axial pump «DON-3» according to the scheme «left ventricle – aorta».Results.A technique was developed and 5 chronic experiments were conducted on sheep to assess the model of the children’s axial pump «DON-3». The duration of the experiments in this series averaged 9 ± 5 days. The main indicators of hemodynamics, acid-base balance were within the norm. Conducted morphological and histological studies of the kidneys, liver and lungs did not reveal the presence of zones of ischemia and thromboembolism.Conclusion.The results of this series of experiments showed satisfactory results, suggesting further research on the development of prototypes of a pediatric pump for clinical practice.

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Acid-Base Balance Determinations in Clinical Practice

Postgraduate Medicine ◽

10.1080/00325481.1965.11696828 ◽

1965 ◽

Vol 38 (4) ◽

pp. A-66-A-74

Author(s):

Ellis S. Benson ◽

R. O. Mulhausen ◽

A. Eichenholz ◽

A. Blumentals

Keyword(s):

Clinical Practice ◽

Acid Base Balance ◽

Acid Base ◽

Base Balance

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Acid-Base Balance Determinations in Clinical Practice

Postgraduate Medicine ◽

10.1080/00325481.1965.11695666 ◽

1965 ◽

Vol 38 (3) ◽

pp. A-48-A-60

Author(s):

Ellis S. Benson ◽

R. O. Mulhausen ◽

A. Eichenholz ◽

A. Blumentals

Keyword(s):

Clinical Practice ◽

Acid Base Balance ◽

Acid Base ◽

Base Balance

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Stress in birds due to routine handling and a technique to avoid it

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1992.263.4.r775 ◽

1992 ◽

Vol 263 (4) ◽

pp. R775-R781 ◽

Cited By ~ 23

Author(s):

Y. Le Maho ◽

H. Karmann ◽

D. Briot ◽

Y. Handrich ◽

J. P. Robin ◽

...

Keyword(s):

Experimental Studies ◽

Blood Levels ◽

Acid Base Balance ◽

Acid Base ◽

Behavioral Observations ◽

Base Balance ◽

Freely Behaving ◽

The Mean ◽

Routine Handling ◽

Induced Changes

The stress that might result in animals from the routine handling that most experimental studies involve, e.g., weighing, injecting, and blood sampling, is usually assumed to be minimal when the animals look quiet. However, the intensity of this stress remains largely ignored. We have developed a system that allows blood samples to be taken from freely behaving geese without entering the animal room. In these entirely undisturbed geese, the humoral indexes of stress, i.e., blood levels of catecholamines, corticosterone, and lactate, were as low or even lower than the lowest values previously reported for birds. Remarkably, the mean basal values for epinephrine and norepinephrine were 90-fold and 5-fold, respectively, below the lowest values in the literature. Stress-induced variations in pH that would have concealed detection of nutrition-induced changes in pH were eliminated. In contrast, even though the birds looked quiet during a short 5-min routine handling procedure, to which they had been accustomed for weeks, there was a dramatic increase in the level of humoral indexes of stress. These increased severalfold within only 2 min, and the return to initial values could take up to 1 h. Acid-base balance was also disrupted. Thus, in studies on animals, the absence of stress cannot be deduced from only behavioral observations. Only a system for taking blood without human interference may enable stress-free investigations.

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Acid-Base Balance Determinations in Clinical Practice

Postgraduate Medicine ◽

10.1080/00325481.1965.11695624 ◽

1965 ◽

Vol 38 (2) ◽

pp. A-46-A-58

Author(s):

A. Blumentals ◽

A. Eichenholz ◽

R. O. Mulhausen

Keyword(s):

Clinical Practice ◽

Acid Base Balance ◽

Acid Base ◽

Base Balance

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Acid-Base Balance in Clinical Practice

Proceedings of the Association of Clinical Biochemists ◽

10.1177/036985646300200615 ◽

1963 ◽

Vol 2 (6) ◽

pp. 140-142

Author(s):

D. K. Brooks

Keyword(s):

Clinical Practice ◽

Acid Base Balance ◽

Acid Base ◽

Base Balance

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Higher Dietary Acidity is Associated with Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000207 ◽

2014 ◽

Vol 84 (3-4) ◽

pp. 0206-0217 ◽

Cited By ~ 8

Author(s):

Seyedeh-Elaheh Shariati-Bafghi ◽

Elaheh Nosrat-Mirshekarlou ◽

Mohsen Karamati ◽

Bahram Rashidkhani

Keyword(s):

Calcium Intake ◽

Dietary Calcium ◽

Dietary Calcium Intake ◽

Dietary Intakes ◽

Iranian Women ◽

Acid Base Balance ◽

Mineral Density ◽

Acid Base ◽

Base Balance ◽

Dietary Acid

Findings of studies on the link between dietary acid-base balance and bone mass are relatively mixed. We examined the association between dietary acid-base balance and bone mineral density (BMD) in a sample of Iranian women, hypothesizing that a higher dietary acidity would be inversely associated with BMD, even when dietary calcium intake is adequate. In this cross-sectional study, lumbar spine and femoral neck BMDs of 151 postmenopausal women aged 50 - 85 years were measured using dual-energy x-ray absorptiometry. Dietary intakes were assessed using a validated food frequency questionnaire. Renal net acid excretion (RNAE), an estimate of acid-base balance, was then calculated indirectly from the diet using the formulae of Remer (based on dietary intakes of protein, phosphorus, potassium, and magnesium; RNAERemer) and Frassetto (based on dietary intakes of protein and potassium; RNAEFrassetto), and was energy adjusted by the residual method. After adjusting for potential confounders, multivariable adjusted means of the lumbar spine BMD of women in the highest tertiles of RNAERemer and RNAEFrassetto were significantly lower than those in the lowest tertiles (for RNAERemer: mean difference -0.084 g/cm2; P=0.007 and for RNAEFrassetto: mean difference - 0.088 g/cm2; P=0.004). Similar results were observed in a subgroup analysis of subjects with dietary calcium intake of >800 mg/day. In conclusion, a higher RNAE (i. e. more dietary acidity), which is associated with greater intake of acid-generating foods and lower intake of alkali-generating foods, may be involved in deteriorating the bone health of postmenopausal Iranian women, even in the context of adequate dietary calcium intake.

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