Cost–effectiveness of high-dose intravenous esomeprazole in patients with peptic ulcer bleeding in the USA and Europe

2010 ◽  
Vol 10 (4) ◽  
pp. 371-374
Author(s):  
Ruth E Brown ◽  
Jyoti Nandi
Keyword(s):  
Peptic Ulcer ◽  
Cost Effectiveness ◽  
Ulcer Bleeding ◽  
High Dose ◽  
Peptic Ulcer Bleeding ◽  
The Usa

The Cost-Effectiveness of High-Dose Intravenous Esomeprazole in Peptic Ulcer Bleeding – a U.S. Cost Perspective

2008 ◽  
Vol 103 ◽  
pp. S48 ◽  
Author(s):  
Alan Barkun ◽  
Vivian Adam ◽  
Joseph Sung ◽  
Ernst Kuipers ◽  
Joachim Mössner ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Cost Effectiveness ◽  
Ulcer Bleeding ◽  
High Dose ◽  
Peptic Ulcer Bleeding ◽  
The Cost

Cost Effectiveness of High-Dose Intravenous Esomeprazole for Peptic Ulcer Bleeding

2010 ◽  
Vol 28 (3) ◽  
pp. 217-230 ◽  
Author(s):  
Alan N. Barkun ◽  
Viviane Adam ◽  
Joseph J.Y. Sung ◽  
Ernst J. Kuipers ◽  
Joachim Mössner ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Cost Effectiveness ◽  
Ulcer Bleeding ◽  
High Dose ◽  
Peptic Ulcer Bleeding

EFFICACY OF INITIAL AND PERMANENT HEMOSTASIS OF THE ENDOSCOPIC HEMOCLIP METHOD COMBINED WITH HIGH-DOSE INFUSION OF PROTON PUMP INHIBITOR IN PATIENTS WITH PEPTIC ULER BLEEDING

2018 ◽  
pp. 15-21
Author(s):  
Hieu Tam Huynh ◽  
Dang Quy Dung Ho
Keyword(s):  
Peptic Ulcer ◽  
Success Rate ◽  
Endoscopic Hemostasis ◽  
Ulcer Bleeding ◽  
Injection Sclerotherapy ◽  
High Dose ◽  
Peptic Ulcers ◽  
Peptic Ulcer Bleeding ◽  
Bleeding Peptic Ulcers ◽  
Hemostatic Therapy

Background: Peptic ulcer bleeding is one of the common medical emergencies. The hemostatic efficacy of endoscopic therapeutic modalities has been reported in many studies and frequently has been found to exceed 90%. Four groups of modalities are used in the endoscopic management of bleeding peptic ulcers: thermal probe methods, injection sclerotherapy, local spray methods, and mechanical hemostatic therapy. The endoscopic hemoclip method is a safe and effective hemostatic therapy for managing bleeding peptic ulcers. Objective: To determine the success rate of hemoclip in endoscopic hemostasis. Patients and methods: Clinical intervention study on 36 patients with peptic ulcer bleeding admitted in Can Tho Central General Hospital from May 2012 to November 2014. All the patients underwent emergency endoscopy for hemostasis by hemoclip and high-dose PPI use. Results: The success rate of initial hemostasis was 97.2%, and permanent hemostasis was 91.7%. The rates of rebleeding, surgery, mortality were 11.1%, 5.6%, 2.8%, respectively. Conclusion: Endoscopic hemostasis therapy by clipping combined with high- dose PPI is an effective, relatively safe treatment for peptic ulcer bleeding. Key words: Peptic ulcer bleeding, hemoclip, endoscopic hemostasis therapy

scholarly journals Pantoprazole for the Treatment of Peptic Ulcer Bleeding and Prevention of Rebleeding

2012 ◽  
Vol 5 ◽  
pp. CGast.S9893 ◽  
Author(s):  
Christo J. Van Rensburg ◽  
Susan Cheer
Keyword(s):  
Peptic Ulcer ◽  
Acute Stress ◽  
Ulcer Bleeding ◽  
High Dose ◽  
Gi Bleeding ◽  
Peptic Ulcer Bleeding ◽  
Stress Ulcers ◽  
Effective Option ◽  
Ulcer Prophylaxis ◽  
Mucosal Bleeding

Adding proton pump inhibitors (PPIs) to endoscopic therapy has become the mainstay of treatment for peptic ulcer bleeding, with current consensus guidelines recommending high-dose intravenous (IV) PPI therapy (IV bolus followed by continuous therapy). However, whether or not high-dose PPI therapy is more effective than low-dose PPI therapy is still debated. Furthermore, maintaining pH ≥ 4 appears to prevent mucosal bleeding in patients with acute stress ulcers; thus, stress ulcer prophylaxis with acid-suppressing therapy has been increasingly recommended in intensive care units (ICUs). This review evaluates the evidence for the efficacy of IV pantoprazole, a PPI, in preventing ulcer rebleeding after endoscopic hemostasis, and in controlling gastric pH and protecting against upper gastrointestinal (GI) bleeding in high-risk ICU patients. The review concludes that IV pantoprazole provides an effective option in the treatment of upper GI bleeding, the prevention of rebleeding, and for the prophylaxis of acute bleeding stress ulcers.

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