scholarly journals Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years

2014 ◽  
Vol 72 (6) ◽  
pp. 451-456 ◽  
Author(s):  
Eric Domingos Mariano ◽  
Chary Marquez Batista ◽  
Breno José Alencar Pires Barbosa ◽  
Suely Kazue Nagahashi Marie ◽  
Manoel Jacobsen Teixeira ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Current Knowledge ◽  
Cell Types ◽  
The Past ◽  
Starting Point ◽  
Cord Injury ◽  
Spinal Cord Repair

Spinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives. Objective : The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy. Method : Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies. Conclusion : The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies.

Mesenchymal stem cell therapy improves erectile dysfunction in experimental spinal cord injury

2019 ◽  
Vol 32 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Ömercan Albayrak ◽  
Tarık Emre Şener ◽  
Mehmet Erşahin ◽  
Suna Özbaş-Turan ◽  
Ceyda Ekentok ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Erectile Dysfunction ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Experimental Spinal Cord Injury ◽  
Cord Injury

Autologous Mesenchymal Stem Cell Therapy for Spinal Cord Injury: Long Term Safety and Clinical Efficacy

2011 ◽  
Vol 3 (1) ◽  
pp. 100-106
Author(s):  
Hala Gabr ◽  
Osama Ghannam ◽  
Mohamed Reda Awad ◽  
Klaus von Wild ◽  
Wael Abo El-Kheir ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Clinical Efficacy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Cord Injury

Stem cell therapy for spinal cord injury

2008 ◽  
Vol 5 (1) ◽  
pp. 7-10
Author(s):  
Khalil Isaac Mathai ◽  
Sasivadanan ◽  
S Sudumbraker ◽  
PK Sahoo
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cord Injury

scholarly journals Molecular Imaging in Stem Cell Therapy for Spinal Cord Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Fahuan Song ◽  
Mei Tian ◽  
Hong Zhang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Molecular Imaging ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cell Biology ◽  
Cell Trafficking ◽  
Imaging Technology ◽  
Cord Injury

Spinal cord injury (SCI) is a serious disease of the center nervous system (CNS). It is a devastating injury with sudden loss of motor, sensory, and autonomic function distal to the level of trauma and produces great personal and societal costs. Currently, there are no remarkable effective therapies for the treatment of SCI. Compared to traditional treatment methods, stem cell transplantation therapy holds potential for repair and functional plasticity after SCI. However, the mechanism of stem cell therapy for SCI remains largely unknown and obscure partly due to the lack of efficient stem cell trafficking methods. Molecular imaging technology including positron emission tomography (PET), magnetic resonance imaging (MRI), optical imaging (i.e., bioluminescence imaging (BLI)) gives the hope to complete the knowledge concerning basic stem cell biology survival, migration, differentiation, and integration in real time when transplanted into damaged spinal cord. In this paper, we mainly review the molecular imaging technology in stem cell therapy for SCI.

scholarly journals Mechanisms of Stem Cell Therapy in Spinal Cord Injuries

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2676
Author(s):  
Munehisa Shinozaki ◽  
Narihito Nagoshi ◽  
Masaya Nakamura ◽  
Hideyuki Okano
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Cell Therapy ◽  
Precision Medicine ◽  
Stem Cell Therapy ◽  
Spinal Cord Injuries ◽  
Pathological Condition ◽  
Chronic Phase ◽  
Cord Injury ◽  
Different Types

Every year, 0.93 million people worldwide suffer from spinal cord injury (SCI) with irretrievable sequelae. Rehabilitation, currently the only available treatment, does not restore damaged tissues; therefore, the functional recovery of patients remains limited. The pathophysiology of spinal cord injuries is heterogeneous, implying that potential therapeutic targets differ depending on the time of injury onset, the degree of injury, or the spinal level of injury. In recent years, despite a significant number of clinical trials based on various types of stem cells, these aspects of injury have not been effectively considered, resulting in difficult outcomes of trials. In a specialty such as cancerology, precision medicine based on a patient’s characteristics has brought indisputable therapeutic advances. The objective of the present review is to promote the development of precision medicine in the field of SCI. Here, we first describe the multifaceted pathophysiology of SCI, with the temporal changes after injury, the characteristics of the chronic phase, and the subtypes of complete injury. We then detail the appropriate targets and related mechanisms of the different types of stem cell therapy for each pathological condition. Finally, we highlight the great potential of stem cell therapy in cervical SCI.

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