Ischemic cerebral changes in the chronic chagasic cardiopathy

The pathological systematized study of the brain of 31 cases of the chronic cardiac form of Chagas' disease was undertaken. Elective parenchymatous necrosis was found in 64.5% of cases, mainly in cerebellar Purkinje cells, and in thalamic nuclei. Also found were multiple foci of old micronecrosis (51.6%) mostly in the cerebral cortex, old cerebral infarcts (22.6%), cortical laminar necrosis (16.1%) and cerebral cortical atrophy (3.2%). These findings are not specific and can be explained by thromboembolic phenomena and hypoxemia following from congestive heart failure and disturbances of the cardiac rhythm.

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MRI Findings of Cortical Laminar Necrosis

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1996.35.5.661 ◽

1996 ◽

Vol 35 (5) ◽

pp. 661

Author(s):

Sai Ra Yoon ◽

Jae Chan Shim ◽

Ghi Jae Lee ◽

Seong Wook Choi ◽

Su Ok Seong ◽

...

Keyword(s):

Mri Findings ◽

Cortical Laminar Necrosis ◽

Cortical Laminar ◽

Laminar Necrosis

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Advanced magnetic resonance imaging of cortical laminar necrosis in patients with stroke

The Neuroradiology Journal ◽

10.1177/1971400919876621 ◽

2019 ◽

Vol 32 (6) ◽

pp. 431-437 ◽

Cited By ~ 1

Author(s):

Roberto Cannella ◽

Gianvincenzo Sparacia ◽

Vincenzina Lo Re ◽

Elisa Oddo ◽

Giuseppe Mamone ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Acute Stage ◽

Arterial Spin Labelling ◽

Resonance Imaging ◽

Cortical Laminar Necrosis ◽

Diffusion Weighted ◽

Cortical Laminar ◽

Laminar Necrosis ◽

Spin Labelling

Purpose The aim of this study was to assess the novel advanced magnetic resonance imaging findings of acute stage cortical laminar necrosis developing after complicated cardiovascular or abdominal surgery. Materials and methods This institutional review board-approved study included patients with postoperative stroke due to cortical laminar necrosis imaged with magnetic resonance in the acute stage. Brain magnetic resonance imaging examinations were obtained on a 3T magnetic resonance scanner within 48 hours of the neurological symptoms, including diffusion-weighted images (b value, 1000 s/mm2) and arterial spin labelling using a pseudo-continuous arterial spin labelling method in four patients. Conventional and advanced magnetic resonance images were analysed to assess the imaging features in acute stage cortical laminar necrosis. Results The final population consisted of 14 patients (seven men and seven women, mean age 61 years, range 32–79 years) diagnosed with stroke and acute phase cortical laminar necrosis. All the patients presented with cortical lesions showing restricted diffusion on diffusion-weighted images and hypointensity on the apparent diffusion coefficient map. Cortical hyperintensity on T2-weighted or fluid-attenuated inversion recovery images was found in three (21%) and six (43%) patients, respectively. Reduced perfusion was noted in three out of four patients imaged with arterial spin labelling, while in one case no corresponding perfusion abnormality was noted on the arterial spin labelling maps. Arterial spin labelling abnormalities were much more extensive than diffusion restriction in two patients, and they were associated with a poor outcome. Conclusion Cortical hyperintense abnormalities on diffusion-weighted imaging may be the only sign of developing cortical laminar necrosis injury. The acquisition of arterial spin labelling helps to identify perfusion alterations and the extension of the ischaemic injury.

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