scholarly journals Misoprostol versus oxytocin for labor induction in term and post-term pregnancy: randomized controlled trial

2003 ◽  
Vol 121 (3) ◽  
pp. 102-106 ◽  
Author(s):  
Márcia Maria Auxiliadora de Aquino ◽  
José Guilherme Cecatti
Keyword(s):  
Randomized Controlled Trial ◽  
Pregnant Women ◽  
Latent Period ◽  
Vaginal Delivery ◽  
Controlled Trial ◽  
Neonatal Morbidity ◽  
Labor Induction ◽  
Cervical Ripening ◽  
Randomized Controlled ◽  
Misoprostol Group

CONTEXT: Misoprostol, a synthetic E1 methyl analog prostaglandin, is at present receiving attention as a cervical modifier and labor induction agent. However, there is still a need for better determination of its safety and effectiveness. OBJECTIVE: To compare intravaginal misoprostol versus intravenous oxytocin for cervical ripening and labor induction in pregnant women with unripe cervices. DESIGN: Randomized controlled trial. SETTING: The study was performed at the Leonor Mendes de Barros Maternity Hospital between November 1998 and December 2000. PARTICIPANTS: 210 pregnant women with intact membranes and indication for labor induction were selected. PROCEDURES: The women randomly received 25 µg of vaginal misoprostol every 4 hours, not exceeding 8 doses (105 women), or oxytocin in a continuous infusion (105 women). MAIN MEASUREMENTS: The main parameters measured were: latent period, time from induction to vaginal delivery, delivery route, occurrence of vaginal delivery with time, occurrence of uterine tonus alterations, hypoxia and neonatal morbidity. To verify the statistical significance of the differences between the groups, the chi-squared, Student t and log-rank tests were used. RESULTS: There were no significant differences between the groups concerning conditions for labor induction, age, parity, race, marital status, family income, initial Bishop Index and number of prenatal visits. The cesarean section rate, latent period and period from induction to vaginal delivery were significantly lower for the misoprostol group. With regard to uterine tonus alterations, tachysystole was significantly more common in the misoprostol group. However, there was no difference in hypoxia and neonatal morbidity between the groups. CONCLUSION: 25 µg of misoprostol used vaginally every 4 hours is safer and more efficient for cervical ripening and labor induction than oxytocin.

scholarly journals Effect of Antenatal Pelvic Floor Muscle Exercise on Mode of Delivery: A Randomized Controlled Trial

2018 ◽  
Vol 4 (3-4) ◽  
pp. 187-197 ◽  
Author(s):  
Fayiz F. El-Shamy ◽  
Eman Abd El Fatah
Keyword(s):  
Randomized Controlled Trial ◽  
Pelvic Floor ◽  
Pregnant Women ◽  
Vaginal Delivery ◽  
Pelvic Floor Muscle ◽  
Controlled Trial ◽  
Mode Of Delivery ◽  
Squeeze Pressure ◽  
Randomized Controlled ◽  
Pfm Strength

Background: Vaginal delivery is the best end of the pregnancy for the mother and the newborn. Aim: To evaluate the impacts of short-term antenatal pelvic floor muscle (PFM) exercises on a woman’s mode of delivery. Methods: This is a randomized controlled trial that recruited 20 healthy pregnant women aged between 20 and 25 years and able to contract the PFMs. The participants were included in the study at 20 weeks of gestation (WG) and were randomly allocated to one of two groups: the intervention group (n = 10) or the control group (n = 10). PFM strength was measured by vaginal squeeze pressure at 20 and 36 WG, and delivery outcomes were evaluated by a blinded searcher from the birth registry after labor. Results: There were no statistically significant changes between both groups at baseline regarding gestational age, type of labor, previous pregnancy complications, and PFM strength (p > 0.05). There was a significant change between both groups in mean PFM strength at 36 WG (p < 0.05). A significant correlation was observed between PFM strength at 36 WG and mode of delivery (vaginal delivery: r = 0.58, p < 0.05; caesarean delivery: r = –0.49, p < 0.05). Conclusions: PFM exercise is recommended for healthy pregnant women as a safe and inexpensive strategy for increasing the vaginal delivery rate.

scholarly journals Effect of "motivational interviewing" and "information, motivation and behavioral skills” on choosing the mode of delivery in pregnant women: A study protocol for a randomized controlled trial

2020 ◽  
Author(s):  
Mahboubeh Shirzad ◽  
Elham Shakibazadeh ◽  
Abbas Rahimi Foroushani ◽  
Mehrandokht Abedini ◽  
Hamid Poursharifi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cesarean Section ◽  
Motivational Interviewing ◽  
Pregnant Women ◽  
Vaginal Delivery ◽  
Controlled Trial ◽  
Mode Of Delivery ◽  
Normal Vaginal Delivery ◽  
Behavioral Skills ◽  
Randomized Controlled

Abstract Background Caesarean Section is an important surgical procedure, when normal vaginal delivery imposes a risk to mother and/or baby. The World Health Organization states the ideal rate for Cesarean section to be between 10% and 15% of all births. Even though, in recent decades, the rate has been increased dramatically worldwide. This paper explains the protocol of a randomized controlled trial that aims to compare the effect of "motivational interviewing" and "information, motivation and behavioral skills” on choosing mode of delivery in pregnant women. Methods/design A four-armed, parallel-design randomized controlled trial will be conducted on pregnant women. One hundred and twenty women will be randomly assigned to three intervention and one control groups. The inclusion criteria include being literate, gestational age from 24 to 32 weeks, being able to speak Persian, having no complications in the current pregnancy, having no indications for CS, and having enough time to participate in the intervention. The most important outcomes of the study include women’s intention to undergo Cesarean section, women’s self-efficacy, and usability of mobile application by the participants, and mode of delivery. Discussion The interventions of this protocol have been programmed to reduce unnecessary Cesarean section. Therefore, after running the protocol, findings may contribute to a rise in normal vaginal delivery. If proven to have an appropriate impact, it may be extended for use in national Cesarean section plans.

scholarly journals A Randomized Controlled Trial of Extra-amniotic Saline Infusion vs Intracervical Dinoprostone Gel for Induction of Labor

2017 ◽  
Vol 1 (1) ◽  
pp. 11-17
Author(s):  
Steffi V Rodrigues ◽  
MK Swamy ◽  
Namrata Jadhav
Keyword(s):  
Randomized Controlled Trial ◽  
Birth Weight ◽  
Vaginal Delivery ◽  
Controlled Trial ◽  
Induction Of Labor ◽  
Saline Infusion ◽  
Cervical Ripening ◽  
Randomized Controlled ◽  
The Mean ◽  
Foley’S Catheter

ABSTRACT Background Success of induction depends largely on cervical ripening and increases the likelihood of vaginal delivery. This study compared the outcomes for induction of labor using extra-amniotic saline infusion (EASI) vs intracervical dinoprostone gel. Objective: Primary: To compare improvement between pre- and post-induction Bishop’s scores in both the groups. Secondary: To compare induction to delivery interval, mode of delivery, and neonatal outcome in both the groups. Materials and methods A randomized controlled trial of 1 year was conducted in the Department of Obstetrics and Gynaecology, Karnataka Lingayat Education University Dr Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka, India, on 82 pregnant women from January 2014 to December 2014. The selected women were divided into two groups of 41 each as group I (induced with dinoprostone) and group II (induced with EASI using Foley’s catheter). Results Significantly higher number of women had postinduction Bishop’s scores between 9 and 12 in the dinoprostone group (70.73%; p < 0.001). The mean Bishop’s scores were significantly high in the dinoprostone gel (9.27 ± 3.07) vs EASI (8.22 ± 2.34; p = 0.086). Cervical ripening based on cut-off score of ≥6 was noted in a significantly higher number of women (92.68%) in EASI (p = 0.241). The mean time for cervical ripening was significantly high in dinoprostone gel group compared with EASI (15.44 ± 8.41 vs 3.88 ± 3.67; p < 0.001), but mean induction to delivery time was comparable (p = 0.086). Significantly higher numbers of vaginal deliveries were noted in dinoprostone group (91.43%; p = 0.001). The neonatal outcomes, i.e., birth weight, mean birth weight, appearance, pulse, grimace, activity, and respiration score at 1 and 5 minutes, and neonatal intensive care unit admission, were comparable (p = 0.570). Conclusion Dinoprostone gel and EASI using Foley’s catheter appear to be effective methods for cervical ripening and labor induction, but dinoprostone gel yielded significantly higher rate of vaginal delivery. How to cite this article Rodrigues SV, Swamy MK, Jadhav N. A Randomized Controlled Trial of Extra-amniotic Saline Infusion vs Intracervical Dinoprostone Gel for Induction of Labor. Int J Gynecol Endsc 2017;1(1):11-17

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