scholarly journals Immunocytochemical study of gastrintestinal endocrine cells in insectivorous bats (Mammalia: Chiroptera)

2008 ◽  
Vol 68 (3) ◽  
pp. 663-669 ◽  
Author(s):  
CM. Santos ◽  
AA. Nascimento ◽  
AL. Peracchi ◽  
A. Sales ◽  
JS. Mikalauskas ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Intestinal Mucosa ◽  
Relative Frequency ◽  
Endocrine Cells ◽  
Alimentary Tract ◽  
Regional Distribution ◽  
Immunocytochemical Study ◽  
Insectivorous Bats ◽  
Molossus Molossus

The regional distribution and relative frequency of endocrine cells in the stomach and intestine of Phyllostomidae: Lonchorhina aurita and Molossidae: Molossus molossus bats were studied immunohistochemically. Three types of immunoreactive (IR) endocrine cells - to serotonin (5-HT), gastrin (GAS) and enteroglucagon (GLUC) - were found in the gastric mucosa and four types of IR cells were identified in the intestinal mucosa. This study showed an interespecfic difference in the regional distribution and relative frequency of endocrine cells in the Chiropteran alimentary tract.

scholarly journals Immunohistochemical distribution of insulin-, glucagon- and somatostatin-containing cells in the pancreas of Lake Van fish (Alburnus tarichi Güldenstädt, 1814) (Cyprinidae)

2019 ◽  
Vol 63 (1) ◽  
Author(s):  
Burak Kaptaner
Keyword(s):  
Adipose Tissue ◽  
Relative Frequency ◽  
Endocrine Cells ◽  
Extrahepatic Bile Duct ◽  
Regional Distribution ◽  
Volume Density ◽  
Pancreatic Tissue ◽  
Pancreatic Ducts ◽  
Lake Van ◽  
Pancreatic Endocrine Cells

The Lake Van fish (Alburnus tarichi) is a species that is endemic to Turkey’s Lake Van basin. In this study, the regional distribution, volume density, and relative frequency of some pancreatic endocrine cells in Lake Van fish were investigated via immunohistochemistry using specific mammalian antibodies. The pancreatic tissue was observed to be surrounded by adipose tissue, which was adjacent to the gall bladder or extrahepatic bile duct, or dispersed in the adipose tissue ranked among coils of post-esophageal swelling and intestine. The pancreatic endocrine cells were examined, including the islets, exocrine pancreas, and pancreatic ducts. According to the modified aldehyde fuchsin staining and immunohistochemistry, insulin-secreting beta cells were observed to localize throughout the islets. Glucagon immune-reactive (IR) cells were observed to be situated moderately on the islet periphery, and were rarely determined in the islet central region. A small number of somatostatin-IR cells were observed in the islet centers and peripheries. Similar distributions of those 3 endocrine cells were also determined in the secondary islets. Additionally, the endocrine cell percentages did not differ between the primary and secondary islets; insulin-, glucagon- and somatostatin-IR cells comprised approximately 54%, 29%, and 11% of the endocrine cells in the principal islets, whereas they comprised 52%, 27%, and 14% in the secondary islets, respectively. Insulin-, glucagon- and somatostatin-IR cells were also determined among the epithelium and subepithelial connective tissue in the pancreatic ducts or exocrine areas of the pancreas. With this study, the existence, regional distribution, and relative frequency of the insulin-, glucagon- and somatostatin-IR cells were first investigated in the pancreatic tissue of Lake Van fish and the results were discussed.

Endocrine Cells of the Gastric Mucosa

1975 ◽  
pp. 223-286 ◽  
Author(s):  
Enrico Solcia ◽  
Carlo Capella ◽  
Gabriele Vassallo ◽  
Roberto Buffa
Keyword(s):  
Gastric Mucosa ◽  
Endocrine Cells

Autoregulation of histamine synthesis through H3 receptors in isolated fundic mucosal cells

1993 ◽  
Vol 265 (6) ◽  
pp. G1039-G1044 ◽  
Author(s):  
F. Hollande ◽  
J. P. Bali ◽  
R. Magous
Keyword(s):  
Gastric Mucosa ◽  
Endocrine Cells ◽  
Histidine Decarboxylase ◽  
Receptor Subtypes ◽  
Histamine Synthesis ◽  
H3 Receptors ◽  
Mucosal Cells ◽  
High Concentrations ◽  
The Relationship ◽  
Stimulation Of

Histamine plays an important role in the control of gastric acid secretion by activating H2 receptors located on parietal cells. In gastric mucosa, histamine is stored both in mast cells and in enterochromaffin-like cells, especially in rodents. It has been proposed that histamine may regulate its own synthesis and/or release through receptors pharmacologically distinct from H1- and H2-receptor subtypes. In this article, we studied the regulation by histamine of histidine decarboxylase (HDC) activity (enzyme responsible for the formation of histamine by decarboxylation of L-histidine) in a fraction of isolated rabbit gastric mucosal cells enriched in mucous and endocrine cells. Histamine and (R)-alpha-methylhistamine (H3 receptor agonist) dose dependently inhibited HDC activity with the same potency (mean effective concn: 32.2 +/- 0.7 and 50.5 +/- 3.1 pM, respectively) and efficacy (35 and 36% inhibition, respectively). In contrast, the H2 agonist dimaprit was devoid of effect. The H3 antagonist thioperamide was found to decrease the histamine- or (R)-alpha-methylhistamine-induced inhibition of HDC activity (mean ineffective concn = 28.3 +/- 1.8 and 9.87 +/- 0.8 nM, respectively), whereas H1 (promethazine) and H2 (ranitidine) antagonists were unable to affect HDC activity. Moreover, high concentrations of thioperamide (1-10 microns) increased histamine release from these cells. All these results allowed us to conclude that, in gastric mucosa, histamine downregulates its own synthesis (and perhaps release) through the stimulation of autoreceptors with pharmacological characteristics of H3 receptors. However, the relationship between histamine synthesis and release remains unclear and needs further investigation.

scholarly journals INTESTINAL OBSTRUCTION

1919 ◽  
Vol 30 (2) ◽  
pp. 109-121 ◽  
Author(s):  
Lester R. Dragstedt ◽  
Carl A. Dragstedt ◽  
John T. McClintock ◽  
C. S. Chase
Keyword(s):  
Intestinal Obstruction ◽  
Blood Supply ◽  
Intestinal Mucosa ◽  
Alimentary Tract ◽  
Intestinal Bacteria ◽  
Acute Obstruction ◽  
Symptom Complex

1. It is impossible to sterilize the intestine by the use of chemical antiseptics even when these are applied directly to the mucosa of isolated segments. 2. The mucosa of the alimentary tract does not elaborate an internal secretion which is necessary to life, or a secretion which could be disturbed by the conditions of acute obstruction so as to account for the symptom complex of that condition. 3. The substances responsible for the toxemia in acute obstruction are produced by the action of intestinal bacteria on proteins or their split products. 4. An injury to the intestinal mucosa, particularly that resulting from disturbances of the blood supply to the intestine, greatly facilitates the absorption of these poisons. The work of Hartwell and his associates and that of Murphy and Brooks on this point are confirmed.

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